Gating mechanism of hyperpolarization-activated HCN pacemaker channels

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are essential for rhythmic activity in the heart and brain. Here authors reverse the voltage dependence of HCN channels by mutating only two residues located at the interface between the voltage sensor and the pore domain.

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Autores principales:	Rosamary Ramentol, Marta E. Perez, H. Peter Larsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2e930f15eab946698c97b37cf9434cbf
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spelling	oai:doaj.org-article:2e930f15eab946698c97b37cf9434cbf2021-12-02T15:39:19ZGating mechanism of hyperpolarization-activated HCN pacemaker channels10.1038/s41467-020-15233-92041-1723https://doaj.org/article/2e930f15eab946698c97b37cf9434cbf2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15233-9https://doaj.org/toc/2041-1723Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are essential for rhythmic activity in the heart and brain. Here authors reverse the voltage dependence of HCN channels by mutating only two residues located at the interface between the voltage sensor and the pore domain.Rosamary RamentolMarta E. PerezH. Peter LarssonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rosamary Ramentol Marta E. Perez H. Peter Larsson Gating mechanism of hyperpolarization-activated HCN pacemaker channels
description	Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are essential for rhythmic activity in the heart and brain. Here authors reverse the voltage dependence of HCN channels by mutating only two residues located at the interface between the voltage sensor and the pore domain.
format	article
author	Rosamary Ramentol Marta E. Perez H. Peter Larsson
author_facet	Rosamary Ramentol Marta E. Perez H. Peter Larsson
author_sort	Rosamary Ramentol
title	Gating mechanism of hyperpolarization-activated HCN pacemaker channels
title_short	Gating mechanism of hyperpolarization-activated HCN pacemaker channels
title_full	Gating mechanism of hyperpolarization-activated HCN pacemaker channels
title_fullStr	Gating mechanism of hyperpolarization-activated HCN pacemaker channels
title_full_unstemmed	Gating mechanism of hyperpolarization-activated HCN pacemaker channels
title_sort	gating mechanism of hyperpolarization-activated hcn pacemaker channels
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2e930f15eab946698c97b37cf9434cbf
work_keys_str_mv	AT rosamaryramentol gatingmechanismofhyperpolarizationactivatedhcnpacemakerchannels AT martaeperez gatingmechanismofhyperpolarizationactivatedhcnpacemakerchannels AT hpeterlarsson gatingmechanismofhyperpolarizationactivatedhcnpacemakerchannels
_version_	1718385923494772736

Gating mechanism of hyperpolarization-activated HCN pacemaker channels

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