Recent Advances in Understanding the Inflammatory Response in Malaria: A Review of the Dual Role of Cytokines

Malaria is a serious and, in some unfortunate cases, fatal disease caused by a parasite of the Plasmodium genus. It predominantly occurs in tropical areas where it is transmitted through the bite of an infected Anopheles mosquito. The pathogenesis of malaria is complex and incompletely elucidated. D...

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Autores principales:	Gabriela Loredana Popa, Mircea Ioan Popa
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/2e93a24fac9b413dacde8ef3c8e8d38f
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spelling	oai:doaj.org-article:2e93a24fac9b413dacde8ef3c8e8d38f2021-11-22T01:09:51ZRecent Advances in Understanding the Inflammatory Response in Malaria: A Review of the Dual Role of Cytokines2314-715610.1155/2021/7785180https://doaj.org/article/2e93a24fac9b413dacde8ef3c8e8d38f2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/7785180https://doaj.org/toc/2314-7156Malaria is a serious and, in some unfortunate cases, fatal disease caused by a parasite of the Plasmodium genus. It predominantly occurs in tropical areas where it is transmitted through the bite of an infected Anopheles mosquito. The pathogenesis of malaria is complex and incompletely elucidated. During blood-stage infection, in response to the presence of the parasite, the host’s immune system produces proinflammatory cytokines including IL-6, IL-8, IFN-γ, and TNF, cytokines which play a pivotal role in controlling the growth of the parasite and its elimination. Regulatory cytokines such as transforming growth factor- (TGF-) β and IL-10 maintain the balance between the proinflammatory and anti-inflammatory responses. However, in many cases, cytokines have a double role. On the one hand, they contribute to parasitic clearance, and on the other, they are responsible for pathological changes encountered in malaria. Cytokine-modulating strategies may represent a promising modern approach in disease management. In this review, we discuss the host immune response in malaria, analyzing the latest studies on the roles of pro- and anti-inflammatory cytokines.Gabriela Loredana PopaMircea Ioan PopaHindawi LimitedarticleImmunologic diseases. AllergyRC581-607ENJournal of Immunology Research, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607
spellingShingle	Immunologic diseases. Allergy RC581-607 Gabriela Loredana Popa Mircea Ioan Popa Recent Advances in Understanding the Inflammatory Response in Malaria: A Review of the Dual Role of Cytokines
description	Malaria is a serious and, in some unfortunate cases, fatal disease caused by a parasite of the Plasmodium genus. It predominantly occurs in tropical areas where it is transmitted through the bite of an infected Anopheles mosquito. The pathogenesis of malaria is complex and incompletely elucidated. During blood-stage infection, in response to the presence of the parasite, the host’s immune system produces proinflammatory cytokines including IL-6, IL-8, IFN-γ, and TNF, cytokines which play a pivotal role in controlling the growth of the parasite and its elimination. Regulatory cytokines such as transforming growth factor- (TGF-) β and IL-10 maintain the balance between the proinflammatory and anti-inflammatory responses. However, in many cases, cytokines have a double role. On the one hand, they contribute to parasitic clearance, and on the other, they are responsible for pathological changes encountered in malaria. Cytokine-modulating strategies may represent a promising modern approach in disease management. In this review, we discuss the host immune response in malaria, analyzing the latest studies on the roles of pro- and anti-inflammatory cytokines.
format	article
author	Gabriela Loredana Popa Mircea Ioan Popa
author_facet	Gabriela Loredana Popa Mircea Ioan Popa
author_sort	Gabriela Loredana Popa
title	Recent Advances in Understanding the Inflammatory Response in Malaria: A Review of the Dual Role of Cytokines
title_short	Recent Advances in Understanding the Inflammatory Response in Malaria: A Review of the Dual Role of Cytokines
title_full	Recent Advances in Understanding the Inflammatory Response in Malaria: A Review of the Dual Role of Cytokines
title_fullStr	Recent Advances in Understanding the Inflammatory Response in Malaria: A Review of the Dual Role of Cytokines
title_full_unstemmed	Recent Advances in Understanding the Inflammatory Response in Malaria: A Review of the Dual Role of Cytokines
title_sort	recent advances in understanding the inflammatory response in malaria: a review of the dual role of cytokines
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/2e93a24fac9b413dacde8ef3c8e8d38f
work_keys_str_mv	AT gabrielaloredanapopa recentadvancesinunderstandingtheinflammatoryresponseinmalariaareviewofthedualroleofcytokines AT mirceaioanpopa recentadvancesinunderstandingtheinflammatoryresponseinmalariaareviewofthedualroleofcytokines
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Recent Advances in Understanding the Inflammatory Response in Malaria: A Review of the Dual Role of Cytokines

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