Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices

Bispecific antibodies have been generated in many different formats and it is becoming clear that rational design alone cannot create optimal functionalities. Here the authors introduce the high throughput methodology, Format Chain Exchange (FORCE), to enable combinatorial generation of bispecific a...

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Autores principales:	Stefan Dengl, Klaus Mayer, Felix Bormann, Harald Duerr, Eike Hoffmann, Bianca Nussbaum, Michael Tischler, Martina Wagner, Andreas Kuglstatter, Lea Leibrock, Can Buldun, Guy Georges, Ulrich Brinkmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2e93ad508e924c6e932a762afd54dddb
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spelling	oai:doaj.org-article:2e93ad508e924c6e932a762afd54dddb2021-12-02T18:51:09ZFormat chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices10.1038/s41467-020-18477-72041-1723https://doaj.org/article/2e93ad508e924c6e932a762afd54dddb2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18477-7https://doaj.org/toc/2041-1723Bispecific antibodies have been generated in many different formats and it is becoming clear that rational design alone cannot create optimal functionalities. Here the authors introduce the high throughput methodology, Format Chain Exchange (FORCE), to enable combinatorial generation of bispecific antibodies.Stefan DenglKlaus MayerFelix BormannHarald DuerrEike HoffmannBianca NussbaumMichael TischlerMartina WagnerAndreas KuglstatterLea LeibrockCan BuldunGuy GeorgesUlrich BrinkmannNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stefan Dengl Klaus Mayer Felix Bormann Harald Duerr Eike Hoffmann Bianca Nussbaum Michael Tischler Martina Wagner Andreas Kuglstatter Lea Leibrock Can Buldun Guy Georges Ulrich Brinkmann Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices
description	Bispecific antibodies have been generated in many different formats and it is becoming clear that rational design alone cannot create optimal functionalities. Here the authors introduce the high throughput methodology, Format Chain Exchange (FORCE), to enable combinatorial generation of bispecific antibodies.
format	article
author	Stefan Dengl Klaus Mayer Felix Bormann Harald Duerr Eike Hoffmann Bianca Nussbaum Michael Tischler Martina Wagner Andreas Kuglstatter Lea Leibrock Can Buldun Guy Georges Ulrich Brinkmann
author_facet	Stefan Dengl Klaus Mayer Felix Bormann Harald Duerr Eike Hoffmann Bianca Nussbaum Michael Tischler Martina Wagner Andreas Kuglstatter Lea Leibrock Can Buldun Guy Georges Ulrich Brinkmann
author_sort	Stefan Dengl
title	Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices
title_short	Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices
title_full	Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices
title_fullStr	Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices
title_full_unstemmed	Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices
title_sort	format chain exchange (force) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2e93ad508e924c6e932a762afd54dddb
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Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices

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