Age-dependent hormesis-like effects of the synthetic cannabinoid CP55940 in C57BL/6 mice

Abstract Use of cannabis and cannabinoid-containing substances is increasing among geriatric patients, despite relatively sparse preclinical evidence in aged models. To better understand the effects of exogenous cannabinoids on aging male and female rodents, we compared the age- and dose-dependent p...

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Autores principales:	Erik L. Hodges, Jessica P. Marshall, Nicole M. Ashpole
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/2e95b6a4d22f47069a1f579a23ea437f
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spelling	oai:doaj.org-article:2e95b6a4d22f47069a1f579a23ea437f2021-12-02T16:24:48ZAge-dependent hormesis-like effects of the synthetic cannabinoid CP55940 in C57BL/6 mice10.1038/s41514-020-0045-72056-3973https://doaj.org/article/2e95b6a4d22f47069a1f579a23ea437f2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41514-020-0045-7https://doaj.org/toc/2056-3973Abstract Use of cannabis and cannabinoid-containing substances is increasing among geriatric patients, despite relatively sparse preclinical evidence in aged models. To better understand the effects of exogenous cannabinoids on aging male and female rodents, we compared the age- and dose-dependent physiological and behavioral effects of the synthetic cannabinoid CP55940 in young–adult and aged C57BL/6 mice. Locomotion, body temperature, thermal nociception, and fecal output were measured following CP55940 administration. Our findings indicate that CP55940 is more potent and efficacious in older mice, evidenced by exaggerated antinociception and locomotor inhibition when compared to younger adult mice. In addition, we report that low doses of CP55940 paradoxically stimulate locomotion in young–adult (4 m) mice; however, this hormesis-like response is not as evident in aged animals (21–24 m). These bidirectional effects appear to be mediated via the endocannabinoid CB1 and CB2 receptors.Erik L. HodgesJessica P. MarshallNicole M. AshpoleNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 6, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Erik L. Hodges Jessica P. Marshall Nicole M. Ashpole Age-dependent hormesis-like effects of the synthetic cannabinoid CP55940 in C57BL/6 mice
description	Abstract Use of cannabis and cannabinoid-containing substances is increasing among geriatric patients, despite relatively sparse preclinical evidence in aged models. To better understand the effects of exogenous cannabinoids on aging male and female rodents, we compared the age- and dose-dependent physiological and behavioral effects of the synthetic cannabinoid CP55940 in young–adult and aged C57BL/6 mice. Locomotion, body temperature, thermal nociception, and fecal output were measured following CP55940 administration. Our findings indicate that CP55940 is more potent and efficacious in older mice, evidenced by exaggerated antinociception and locomotor inhibition when compared to younger adult mice. In addition, we report that low doses of CP55940 paradoxically stimulate locomotion in young–adult (4 m) mice; however, this hormesis-like response is not as evident in aged animals (21–24 m). These bidirectional effects appear to be mediated via the endocannabinoid CB1 and CB2 receptors.
format	article
author	Erik L. Hodges Jessica P. Marshall Nicole M. Ashpole
author_facet	Erik L. Hodges Jessica P. Marshall Nicole M. Ashpole
author_sort	Erik L. Hodges
title	Age-dependent hormesis-like effects of the synthetic cannabinoid CP55940 in C57BL/6 mice
title_short	Age-dependent hormesis-like effects of the synthetic cannabinoid CP55940 in C57BL/6 mice
title_full	Age-dependent hormesis-like effects of the synthetic cannabinoid CP55940 in C57BL/6 mice
title_fullStr	Age-dependent hormesis-like effects of the synthetic cannabinoid CP55940 in C57BL/6 mice
title_full_unstemmed	Age-dependent hormesis-like effects of the synthetic cannabinoid CP55940 in C57BL/6 mice
title_sort	age-dependent hormesis-like effects of the synthetic cannabinoid cp55940 in c57bl/6 mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2e95b6a4d22f47069a1f579a23ea437f
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Age-dependent hormesis-like effects of the synthetic cannabinoid CP55940 in C57BL/6 mice

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