Role of berberine in Alzheimer’s disease
Zhiyou Cai,1,* Chuanling Wang,1,* Wenming Yang2 1Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan Renmin Hospital, Shiyan, Hubei Province, 2Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, People&...
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Dove Medical Press
2016
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oai:doaj.org-article:2e983941beb440e4a64327344f694f272021-12-02T01:01:22ZRole of berberine in Alzheimer’s disease1178-2021https://doaj.org/article/2e983941beb440e4a64327344f694f272016-10-01T00:00:00Zhttps://www.dovepress.com/role-of-berberine-in-alzheimerrsquos-disease-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Zhiyou Cai,1,* Chuanling Wang,1,* Wenming Yang2 1Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan Renmin Hospital, Shiyan, Hubei Province, 2Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, People’s Republic of China *These authors contributed equally to this work Abstract: Berberine, an important protoberberine isoquinoline alkaloid, has several pharmacological activities, including antimicrobial, glucose- and cholesterol-lowering, antitumoral, and immunomodulatory properties. Substantial studies suggest that berberine may be beneficial to Alzheimer’s disease (AD) by limiting the pathogenesis of extracellular amyloid plaques and intracellular neurofibrillary tangles. Increasing evidence has indicated that berberine exerts a protective role in atherosclerosis related to lipid- and glucose-lowering properties, implicating that berberine has the potential to inhibit these risk factors for AD. This review also attempts to discuss the pharmacological basis through which berberine may retard oxidative stress and neuroinflammation to exhibit its protective role in AD. Accordingly, berberine might be considered a potential therapeutic approach to prevent or delay the process of AD. However, more detailed investigations along with a safety assessment of berberine are warranted to clarify the role of berberine in limiting these risk factors and AD-related pathologies. Keywords: berberine, amyloid, tau, oxidative stress, neuroinflammation, risk factorsCai ZWang CYang WDove Medical PressarticleBerberineamyloidtauoxidative stressneuroinflammationrisk factorsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 2509-2520 (2016) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Berberine amyloid tau oxidative stress neuroinflammation risk factors Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Berberine amyloid tau oxidative stress neuroinflammation risk factors Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Cai Z Wang C Yang W Role of berberine in Alzheimer’s disease |
| description |
Zhiyou Cai,1,* Chuanling Wang,1,* Wenming Yang2 1Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan Renmin Hospital, Shiyan, Hubei Province, 2Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, People’s Republic of China *These authors contributed equally to this work Abstract: Berberine, an important protoberberine isoquinoline alkaloid, has several pharmacological activities, including antimicrobial, glucose- and cholesterol-lowering, antitumoral, and immunomodulatory properties. Substantial studies suggest that berberine may be beneficial to Alzheimer’s disease (AD) by limiting the pathogenesis of extracellular amyloid plaques and intracellular neurofibrillary tangles. Increasing evidence has indicated that berberine exerts a protective role in atherosclerosis related to lipid- and glucose-lowering properties, implicating that berberine has the potential to inhibit these risk factors for AD. This review also attempts to discuss the pharmacological basis through which berberine may retard oxidative stress and neuroinflammation to exhibit its protective role in AD. Accordingly, berberine might be considered a potential therapeutic approach to prevent or delay the process of AD. However, more detailed investigations along with a safety assessment of berberine are warranted to clarify the role of berberine in limiting these risk factors and AD-related pathologies. Keywords: berberine, amyloid, tau, oxidative stress, neuroinflammation, risk factors |
| format |
article |
| author |
Cai Z Wang C Yang W |
| author_facet |
Cai Z Wang C Yang W |
| author_sort |
Cai Z |
| title |
Role of berberine in Alzheimer’s disease |
| title_short |
Role of berberine in Alzheimer’s disease |
| title_full |
Role of berberine in Alzheimer’s disease |
| title_fullStr |
Role of berberine in Alzheimer’s disease |
| title_full_unstemmed |
Role of berberine in Alzheimer’s disease |
| title_sort |
role of berberine in alzheimer’s disease |
| publisher |
Dove Medical Press |
| publishDate |
2016 |
| url |
https://doaj.org/article/2e983941beb440e4a64327344f694f27 |
| work_keys_str_mv |
AT caiz roleofberberineinalzheimerrsquosdisease AT wangc roleofberberineinalzheimerrsquosdisease AT yangw roleofberberineinalzheimerrsquosdisease |
| _version_ |
1718403374387298304 |