Indicators of the Immune Status in Children after a New Coronavirus Infection

Background. The mechanism of the immune response in patients with COVID-19 is still poorly understood and differs from other respiratory infections. Immunodeficiencies and age-related characteristics of immunity can be regarded as factors influencing reinfection and a predisposition to prolonged per...

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Autores principales:	E. V. Moskaleva, A. G. Petrova, L. V. Rychkova, E. A. Novikova, A. S. Vanyarkinа
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	children covid-19 immunity Science Q
Acceso en línea:	https://doaj.org/article/2ea3aa12366c46a3ab6276b4d3e58e2c
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spelling	oai:doaj.org-article:2ea3aa12366c46a3ab6276b4d3e58e2c2021-11-23T06:14:45ZIndicators of the Immune Status in Children after a New Coronavirus Infection2541-94202587-959610.29413/ABS.2021-6.2.6https://doaj.org/article/2ea3aa12366c46a3ab6276b4d3e58e2c2021-06-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2729https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. The mechanism of the immune response in patients with COVID-19 is still poorly understood and differs from other respiratory infections. Immunodeficiencies and age-related characteristics of immunity can be regarded as factors influencing reinfection and a predisposition to prolonged persistence of SARS-CoV-2. Most of the studies report about post-infection immunity to SARS-CoV-2 for adults and less for children. However, understanding the dynamics of antibody production to SARS-CoV-2 among children as well as other unique features of immune response is extremely important, because this provides to avoid possible complications and long-term outcomes of COVID-19, and predict the epidemic spread of the new coronavirus in the organized groups of children such as kindergartens, schools, study groups and clubs.Aim: to evaluate the humoral and cellular immunity after SARS-CoV-2 infection in children.Materials and methods. We reported data of the first phase prospective cohort study of immunity among 60 children living in Irkutsk, Russia within a month after SARS-CoV-2 infection, which took place in October and November 2020.Results. Immunity of children one month after SARS-Cov-2 infection was characterized by suppressed cell-mediated and humoral immunity, and phagocytosis dysfunction. Reduced phagocytosis by neutrophils was noted for 61.6 % of individuals.Conclusions. Children after COVID-19 had impaired immunity to SARS-CoV-2, which may be a predictor of chronic infection and other long-term outcomes of COVID-19.E. V. MoskalevaA. G. PetrovaL. V. RychkovaE. A. NovikovaA. S. VanyarkinаScientific Сentre for Family Health and Human Reproduction Problemsarticlechildrencovid-19immunityScienceQRUActa Biomedica Scientifica, Vol 6, Iss 2, Pp 58-62 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	children covid-19 immunity Science Q
spellingShingle	children covid-19 immunity Science Q E. V. Moskaleva A. G. Petrova L. V. Rychkova E. A. Novikova A. S. Vanyarkinа Indicators of the Immune Status in Children after a New Coronavirus Infection
description	Background. The mechanism of the immune response in patients with COVID-19 is still poorly understood and differs from other respiratory infections. Immunodeficiencies and age-related characteristics of immunity can be regarded as factors influencing reinfection and a predisposition to prolonged persistence of SARS-CoV-2. Most of the studies report about post-infection immunity to SARS-CoV-2 for adults and less for children. However, understanding the dynamics of antibody production to SARS-CoV-2 among children as well as other unique features of immune response is extremely important, because this provides to avoid possible complications and long-term outcomes of COVID-19, and predict the epidemic spread of the new coronavirus in the organized groups of children such as kindergartens, schools, study groups and clubs.Aim: to evaluate the humoral and cellular immunity after SARS-CoV-2 infection in children.Materials and methods. We reported data of the first phase prospective cohort study of immunity among 60 children living in Irkutsk, Russia within a month after SARS-CoV-2 infection, which took place in October and November 2020.Results. Immunity of children one month after SARS-Cov-2 infection was characterized by suppressed cell-mediated and humoral immunity, and phagocytosis dysfunction. Reduced phagocytosis by neutrophils was noted for 61.6 % of individuals.Conclusions. Children after COVID-19 had impaired immunity to SARS-CoV-2, which may be a predictor of chronic infection and other long-term outcomes of COVID-19.
format	article
author	E. V. Moskaleva A. G. Petrova L. V. Rychkova E. A. Novikova A. S. Vanyarkinа
author_facet	E. V. Moskaleva A. G. Petrova L. V. Rychkova E. A. Novikova A. S. Vanyarkinа
author_sort	E. V. Moskaleva
title	Indicators of the Immune Status in Children after a New Coronavirus Infection
title_short	Indicators of the Immune Status in Children after a New Coronavirus Infection
title_full	Indicators of the Immune Status in Children after a New Coronavirus Infection
title_fullStr	Indicators of the Immune Status in Children after a New Coronavirus Infection
title_full_unstemmed	Indicators of the Immune Status in Children after a New Coronavirus Infection
title_sort	indicators of the immune status in children after a new coronavirus infection
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/2ea3aa12366c46a3ab6276b4d3e58e2c
work_keys_str_mv	AT evmoskaleva indicatorsoftheimmunestatusinchildrenafteranewcoronavirusinfection AT agpetrova indicatorsoftheimmunestatusinchildrenafteranewcoronavirusinfection AT lvrychkova indicatorsoftheimmunestatusinchildrenafteranewcoronavirusinfection AT eanovikova indicatorsoftheimmunestatusinchildrenafteranewcoronavirusinfection AT asvanyarkina indicatorsoftheimmunestatusinchildrenafteranewcoronavirusinfection
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Indicators of the Immune Status in Children after a New Coronavirus Infection

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