Conformational ensemble of the human TRPV3 ion channel

Transient receptor potential vanilloid channel 3 (TRPV3) responds to temperature and sensitizes upon repeated stimulation with either heat or agonists. Here authors present the cryo-EM structures of apo and sensitized human TRPV3 and describe the structural basis of sensitization.

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Autores principales: Lejla Zubcevic, Mark A. Herzik, Mengyu Wu, William F. Borschel, Marscha Hirschi, Albert S. Song, Gabriel C. Lander, Seok-Yong Lee
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/2ea7563e099f422d909405e9c45dad14
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spelling oai:doaj.org-article:2ea7563e099f422d909405e9c45dad142021-12-02T14:41:29ZConformational ensemble of the human TRPV3 ion channel10.1038/s41467-018-07117-w2041-1723https://doaj.org/article/2ea7563e099f422d909405e9c45dad142018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07117-whttps://doaj.org/toc/2041-1723Transient receptor potential vanilloid channel 3 (TRPV3) responds to temperature and sensitizes upon repeated stimulation with either heat or agonists. Here authors present the cryo-EM structures of apo and sensitized human TRPV3 and describe the structural basis of sensitization.Lejla ZubcevicMark A. HerzikMengyu WuWilliam F. BorschelMarscha HirschiAlbert S. SongGabriel C. LanderSeok-Yong LeeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lejla Zubcevic
Mark A. Herzik
Mengyu Wu
William F. Borschel
Marscha Hirschi
Albert S. Song
Gabriel C. Lander
Seok-Yong Lee
Conformational ensemble of the human TRPV3 ion channel
description Transient receptor potential vanilloid channel 3 (TRPV3) responds to temperature and sensitizes upon repeated stimulation with either heat or agonists. Here authors present the cryo-EM structures of apo and sensitized human TRPV3 and describe the structural basis of sensitization.
format article
author Lejla Zubcevic
Mark A. Herzik
Mengyu Wu
William F. Borschel
Marscha Hirschi
Albert S. Song
Gabriel C. Lander
Seok-Yong Lee
author_facet Lejla Zubcevic
Mark A. Herzik
Mengyu Wu
William F. Borschel
Marscha Hirschi
Albert S. Song
Gabriel C. Lander
Seok-Yong Lee
author_sort Lejla Zubcevic
title Conformational ensemble of the human TRPV3 ion channel
title_short Conformational ensemble of the human TRPV3 ion channel
title_full Conformational ensemble of the human TRPV3 ion channel
title_fullStr Conformational ensemble of the human TRPV3 ion channel
title_full_unstemmed Conformational ensemble of the human TRPV3 ion channel
title_sort conformational ensemble of the human trpv3 ion channel
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/2ea7563e099f422d909405e9c45dad14
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AT markaherzik conformationalensembleofthehumantrpv3ionchannel
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AT williamfborschel conformationalensembleofthehumantrpv3ionchannel
AT marschahirschi conformationalensembleofthehumantrpv3ionchannel
AT albertssong conformationalensembleofthehumantrpv3ionchannel
AT gabrielclander conformationalensembleofthehumantrpv3ionchannel
AT seokyonglee conformationalensembleofthehumantrpv3ionchannel
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