Conformational ensemble of the human TRPV3 ion channel
Transient receptor potential vanilloid channel 3 (TRPV3) responds to temperature and sensitizes upon repeated stimulation with either heat or agonists. Here authors present the cryo-EM structures of apo and sensitized human TRPV3 and describe the structural basis of sensitization.
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Nature Portfolio
2018
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oai:doaj.org-article:2ea7563e099f422d909405e9c45dad142021-12-02T14:41:29ZConformational ensemble of the human TRPV3 ion channel10.1038/s41467-018-07117-w2041-1723https://doaj.org/article/2ea7563e099f422d909405e9c45dad142018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07117-whttps://doaj.org/toc/2041-1723Transient receptor potential vanilloid channel 3 (TRPV3) responds to temperature and sensitizes upon repeated stimulation with either heat or agonists. Here authors present the cryo-EM structures of apo and sensitized human TRPV3 and describe the structural basis of sensitization.Lejla ZubcevicMark A. HerzikMengyu WuWilliam F. BorschelMarscha HirschiAlbert S. SongGabriel C. LanderSeok-Yong LeeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
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Science Q Lejla Zubcevic Mark A. Herzik Mengyu Wu William F. Borschel Marscha Hirschi Albert S. Song Gabriel C. Lander Seok-Yong Lee Conformational ensemble of the human TRPV3 ion channel |
description |
Transient receptor potential vanilloid channel 3 (TRPV3) responds to temperature and sensitizes upon repeated stimulation with either heat or agonists. Here authors present the cryo-EM structures of apo and sensitized human TRPV3 and describe the structural basis of sensitization. |
format |
article |
author |
Lejla Zubcevic Mark A. Herzik Mengyu Wu William F. Borschel Marscha Hirschi Albert S. Song Gabriel C. Lander Seok-Yong Lee |
author_facet |
Lejla Zubcevic Mark A. Herzik Mengyu Wu William F. Borschel Marscha Hirschi Albert S. Song Gabriel C. Lander Seok-Yong Lee |
author_sort |
Lejla Zubcevic |
title |
Conformational ensemble of the human TRPV3 ion channel |
title_short |
Conformational ensemble of the human TRPV3 ion channel |
title_full |
Conformational ensemble of the human TRPV3 ion channel |
title_fullStr |
Conformational ensemble of the human TRPV3 ion channel |
title_full_unstemmed |
Conformational ensemble of the human TRPV3 ion channel |
title_sort |
conformational ensemble of the human trpv3 ion channel |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/2ea7563e099f422d909405e9c45dad14 |
work_keys_str_mv |
AT lejlazubcevic conformationalensembleofthehumantrpv3ionchannel AT markaherzik conformationalensembleofthehumantrpv3ionchannel AT mengyuwu conformationalensembleofthehumantrpv3ionchannel AT williamfborschel conformationalensembleofthehumantrpv3ionchannel AT marschahirschi conformationalensembleofthehumantrpv3ionchannel AT albertssong conformationalensembleofthehumantrpv3ionchannel AT gabrielclander conformationalensembleofthehumantrpv3ionchannel AT seokyonglee conformationalensembleofthehumantrpv3ionchannel |
_version_ |
1718389860011606016 |