Conformational ensemble of the human TRPV3 ion channel

Conformational ensemble of the human TRPV3 ion channel

Transient receptor potential vanilloid channel 3 (TRPV3) responds to temperature and sensitizes upon repeated stimulation with either heat or agonists. Here authors present the cryo-EM structures of apo and sensitized human TRPV3 and describe the structural basis of sensitization.

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Autores principales: Lejla Zubcevic, Mark A. Herzik, Mengyu Wu, William F. Borschel, Marscha Hirschi, Albert S. Song, Gabriel C. Lander, Seok-Yong Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/2ea7563e099f422d909405e9c45dad14
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