The effect of caffeine on tinnitus: Randomized triple-blind placebo-controlled clinical trial.

<h4>Objective</h4>To test the hypothesis that caffeine can influence tinnitus, we recruited 80 patients with chronic tinnitus and randomly allocated them into two groups (caffeine and placebo) to analyze the self-perception of tinnitus symptoms after caffeine consumption, assuming that t...

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Autores principales:	Alleluia Lima Losno Ledesma, Daniele Leite Rodrigues, Isabella Monteiro de Castro Silva, Carlos Augusto Oliveira, Fayez Bahmad
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2ea799874e924546a880227c41f121db
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spelling	oai:doaj.org-article:2ea799874e924546a880227c41f121db2021-12-02T20:08:10ZThe effect of caffeine on tinnitus: Randomized triple-blind placebo-controlled clinical trial.1932-620310.1371/journal.pone.0256275https://doaj.org/article/2ea799874e924546a880227c41f121db2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256275https://doaj.org/toc/1932-6203<h4>Objective</h4>To test the hypothesis that caffeine can influence tinnitus, we recruited 80 patients with chronic tinnitus and randomly allocated them into two groups (caffeine and placebo) to analyze the self-perception of tinnitus symptoms after caffeine consumption, assuming that this is an adequate sample for generalization.<h4>Methods</h4>The participants were randomized into two groups: one group was administered a 300-mg capsule of caffeine, and the other group was given a placebo capsule (cornstarch). A diet that restricted caffeine consumption for 24 hours was implemented. The participants answered questionnaires (the Tinnitus Handicap Inventory-THI, the Visual Analog Scale-VAS, the profile of mood state-POMS) and underwent examinations (tonal and high frequency audiometry, acufenometry (frequency measure; intensity measure and the minimum level of tinnitus masking), transient otoacoustic emissions-TEOAE and distortion product otoacoustic emissions-DPOAE assessments) at two timepoints: at baseline and after capsule ingestion.<h4>Results</h4>There was a significant change in mood (measured by the POMS) after caffeine consumption. The THI and VAS scores were improved at the second timepoint in both groups. The audiometry assessment showed a significant difference in some frequencies between baseline and follow-up measurements in both groups, but these differences were not clinically relevant. Similar findings were observed for the amplitude and signal-to-noise ratio in the TEOAE and DPOAE measurements.<h4>Conclusions</h4>Caffeine (300 mg) did not significantly alter the psychoacoustic measures, electroacoustic measures or the tinnitus-related degree of discomfort.Alleluia Lima Losno LedesmaDaniele Leite RodriguesIsabella Monteiro de Castro SilvaCarlos Augusto OliveiraFayez BahmadPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0256275 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alleluia Lima Losno Ledesma Daniele Leite Rodrigues Isabella Monteiro de Castro Silva Carlos Augusto Oliveira Fayez Bahmad The effect of caffeine on tinnitus: Randomized triple-blind placebo-controlled clinical trial.
description	<h4>Objective</h4>To test the hypothesis that caffeine can influence tinnitus, we recruited 80 patients with chronic tinnitus and randomly allocated them into two groups (caffeine and placebo) to analyze the self-perception of tinnitus symptoms after caffeine consumption, assuming that this is an adequate sample for generalization.<h4>Methods</h4>The participants were randomized into two groups: one group was administered a 300-mg capsule of caffeine, and the other group was given a placebo capsule (cornstarch). A diet that restricted caffeine consumption for 24 hours was implemented. The participants answered questionnaires (the Tinnitus Handicap Inventory-THI, the Visual Analog Scale-VAS, the profile of mood state-POMS) and underwent examinations (tonal and high frequency audiometry, acufenometry (frequency measure; intensity measure and the minimum level of tinnitus masking), transient otoacoustic emissions-TEOAE and distortion product otoacoustic emissions-DPOAE assessments) at two timepoints: at baseline and after capsule ingestion.<h4>Results</h4>There was a significant change in mood (measured by the POMS) after caffeine consumption. The THI and VAS scores were improved at the second timepoint in both groups. The audiometry assessment showed a significant difference in some frequencies between baseline and follow-up measurements in both groups, but these differences were not clinically relevant. Similar findings were observed for the amplitude and signal-to-noise ratio in the TEOAE and DPOAE measurements.<h4>Conclusions</h4>Caffeine (300 mg) did not significantly alter the psychoacoustic measures, electroacoustic measures or the tinnitus-related degree of discomfort.
format	article
author	Alleluia Lima Losno Ledesma Daniele Leite Rodrigues Isabella Monteiro de Castro Silva Carlos Augusto Oliveira Fayez Bahmad
author_facet	Alleluia Lima Losno Ledesma Daniele Leite Rodrigues Isabella Monteiro de Castro Silva Carlos Augusto Oliveira Fayez Bahmad
author_sort	Alleluia Lima Losno Ledesma
title	The effect of caffeine on tinnitus: Randomized triple-blind placebo-controlled clinical trial.
title_short	The effect of caffeine on tinnitus: Randomized triple-blind placebo-controlled clinical trial.
title_full	The effect of caffeine on tinnitus: Randomized triple-blind placebo-controlled clinical trial.
title_fullStr	The effect of caffeine on tinnitus: Randomized triple-blind placebo-controlled clinical trial.
title_full_unstemmed	The effect of caffeine on tinnitus: Randomized triple-blind placebo-controlled clinical trial.
title_sort	effect of caffeine on tinnitus: randomized triple-blind placebo-controlled clinical trial.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/2ea799874e924546a880227c41f121db
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The effect of caffeine on tinnitus: Randomized triple-blind placebo-controlled clinical trial.

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