Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells

In Drosophila the Male-Specific Lethal complex (MSLc) mediates upregulation of the single male X chromosome. Here the authors provide evidence that MSL2 also targets autosomal genes required for proper development and that MSL2 binds and similarly regulates mouse orthologues.

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Autores principales:	Claudia Isabelle Keller Valsecchi, M. Felicia Basilicata, Giuseppe Semplicio, Plamen Georgiev, Noel Marie Gutierrez, Asifa Akhtar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2ea84366ae2041c79025b7945fc301b4
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spelling	oai:doaj.org-article:2ea84366ae2041c79025b7945fc301b42021-12-02T17:33:03ZFacultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells10.1038/s41467-018-05642-22041-1723https://doaj.org/article/2ea84366ae2041c79025b7945fc301b42018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05642-2https://doaj.org/toc/2041-1723In Drosophila the Male-Specific Lethal complex (MSLc) mediates upregulation of the single male X chromosome. Here the authors provide evidence that MSL2 also targets autosomal genes required for proper development and that MSL2 binds and similarly regulates mouse orthologues.Claudia Isabelle Keller ValsecchiM. Felicia BasilicataGiuseppe SemplicioPlamen GeorgievNoel Marie GutierrezAsifa AkhtarNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Claudia Isabelle Keller Valsecchi M. Felicia Basilicata Giuseppe Semplicio Plamen Georgiev Noel Marie Gutierrez Asifa Akhtar Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells
description	In Drosophila the Male-Specific Lethal complex (MSLc) mediates upregulation of the single male X chromosome. Here the authors provide evidence that MSL2 also targets autosomal genes required for proper development and that MSL2 binds and similarly regulates mouse orthologues.
format	article
author	Claudia Isabelle Keller Valsecchi M. Felicia Basilicata Giuseppe Semplicio Plamen Georgiev Noel Marie Gutierrez Asifa Akhtar
author_facet	Claudia Isabelle Keller Valsecchi M. Felicia Basilicata Giuseppe Semplicio Plamen Georgiev Noel Marie Gutierrez Asifa Akhtar
author_sort	Claudia Isabelle Keller Valsecchi
title	Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells
title_short	Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells
title_full	Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells
title_fullStr	Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells
title_full_unstemmed	Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells
title_sort	facultative dosage compensation of developmental genes on autosomes in drosophila and mouse embryonic stem cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2ea84366ae2041c79025b7945fc301b4
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Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells

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