Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells

In Drosophila the Male-Specific Lethal complex (MSLc) mediates upregulation of the single male X chromosome. Here the authors provide evidence that MSL2 also targets autosomal genes required for proper development and that MSL2 binds and similarly regulates mouse orthologues.

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Autores principales: Claudia Isabelle Keller Valsecchi, M. Felicia Basilicata, Giuseppe Semplicio, Plamen Georgiev, Noel Marie Gutierrez, Asifa Akhtar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/2ea84366ae2041c79025b7945fc301b4
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