Neuropsychological effects of antiepileptic drugs (carbamazepine versus valproate) in adult males with epilepsy

Ghaydaa A Shehata,1 Abd El-aziz M Bateh,2 Sherifa A Hamed,1 Tarek A Rageh,1 Yaser B Elsorogy11Department of Neurology and Psychiatry, Faculty of Medicine, Assiut University, Egypt; 2Department of Psychology, Faculty of Arts, Banha University, EgyptPurpose: To evaluate the effect of antiepileptic dru...

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Autores principales:	Ghaydaa A Shehata, Abd El-aziz M Bateh, Sherifa A Hamed, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/2eaa75fb715a4d38b3837c6a074a3546
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spelling	oai:doaj.org-article:2eaa75fb715a4d38b3837c6a074a35462021-12-02T02:03:59ZNeuropsychological effects of antiepileptic drugs (carbamazepine versus valproate) in adult males with epilepsy1176-63281178-2021https://doaj.org/article/2eaa75fb715a4d38b3837c6a074a35462009-10-01T00:00:00Zhttp://www.dovepress.com/neuropsychological-effects-of-antiepileptic-drugs-carbamazepine-versus-a3633https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Ghaydaa A Shehata,1 Abd El-aziz M Bateh,2 Sherifa A Hamed,1 Tarek A Rageh,1 Yaser B Elsorogy11Department of Neurology and Psychiatry, Faculty of Medicine, Assiut University, Egypt; 2Department of Psychology, Faculty of Arts, Banha University, EgyptPurpose: To evaluate the effect of antiepileptic drugs (AEDs) on cognition and behavior in adult epileptic males controlled on treatment with conventional antiepileptic medications. Methods: Cognitive, mood, behavior and personality traits were assessed in 45 epileptic patients treated with carbamazepine and/or valproate and free of seizures for &ge;1 year. Thirty-four newly diagnosed or untreated patients with epilepsy and 58 matched healthy subjects were also included for comparison. A battery of psychometric tests was utilized including Stanford-Binet (4th edition), Beck Inventory for Depression, Aggressive Scale and Eysenck Personality Questionnaire.Results: Compared to matched control subjects, treated and untreated epileptic patients had poor performance in different cognitive and behavioral functions testing. Treated patients had worse scores in memory for digits forward and backward, total short-term memory, extroversion and psychosis. The duration of AEDs intake was correlated with memory of objects (r = -0.323; P = 0.030), bead memory (r = -0.314; P = 0.036) and total nonverbal short-term memory (r = -0.346; P = 0.020). Treated and untreated epileptic patients had poor performance of similar extent in behavioral functions testing (depression, aggression and neurosis). The dose of AEDs was correlated with testing scores for neurosis (r = 0.307; P = 0.040), verbal aggression (r = 0.483; P = 0.001) and nonverbal aggression (r = 0.526; P = 0.000), and duration of drug intake was correlated with scores for depression (r = 0.384; P = 0.009), psychosis (r = 0.586; P = 0.0001) and nonverbal aggression (r = 0.300; P = 0.045).Conclusions: This study provides support for the notion that AEDs can impair performance in cognition, mood and behavior. Duration of drug intake and the number of the utilized AEDs are the main confounding variables. This study did not provide clues on how to exclude the effect of epilepsy itself and psychosocial variables as additional important confounding variables.Keywords: cognition, behavior, mood, personality traits, epilepsy, AEDs Ghaydaa A ShehataAbd El-aziz M BatehSherifa A Hamedet alDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2009, Iss default, Pp 527-533 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Ghaydaa A Shehata Abd El-aziz M Bateh Sherifa A Hamed et al Neuropsychological effects of antiepileptic drugs (carbamazepine versus valproate) in adult males with epilepsy
description	Ghaydaa A Shehata,1 Abd El-aziz M Bateh,2 Sherifa A Hamed,1 Tarek A Rageh,1 Yaser B Elsorogy11Department of Neurology and Psychiatry, Faculty of Medicine, Assiut University, Egypt; 2Department of Psychology, Faculty of Arts, Banha University, EgyptPurpose: To evaluate the effect of antiepileptic drugs (AEDs) on cognition and behavior in adult epileptic males controlled on treatment with conventional antiepileptic medications. Methods: Cognitive, mood, behavior and personality traits were assessed in 45 epileptic patients treated with carbamazepine and/or valproate and free of seizures for &ge;1 year. Thirty-four newly diagnosed or untreated patients with epilepsy and 58 matched healthy subjects were also included for comparison. A battery of psychometric tests was utilized including Stanford-Binet (4th edition), Beck Inventory for Depression, Aggressive Scale and Eysenck Personality Questionnaire.Results: Compared to matched control subjects, treated and untreated epileptic patients had poor performance in different cognitive and behavioral functions testing. Treated patients had worse scores in memory for digits forward and backward, total short-term memory, extroversion and psychosis. The duration of AEDs intake was correlated with memory of objects (r = -0.323; P = 0.030), bead memory (r = -0.314; P = 0.036) and total nonverbal short-term memory (r = -0.346; P = 0.020). Treated and untreated epileptic patients had poor performance of similar extent in behavioral functions testing (depression, aggression and neurosis). The dose of AEDs was correlated with testing scores for neurosis (r = 0.307; P = 0.040), verbal aggression (r = 0.483; P = 0.001) and nonverbal aggression (r = 0.526; P = 0.000), and duration of drug intake was correlated with scores for depression (r = 0.384; P = 0.009), psychosis (r = 0.586; P = 0.0001) and nonverbal aggression (r = 0.300; P = 0.045).Conclusions: This study provides support for the notion that AEDs can impair performance in cognition, mood and behavior. Duration of drug intake and the number of the utilized AEDs are the main confounding variables. This study did not provide clues on how to exclude the effect of epilepsy itself and psychosocial variables as additional important confounding variables.Keywords: cognition, behavior, mood, personality traits, epilepsy, AEDs
format	article
author	Ghaydaa A Shehata Abd El-aziz M Bateh Sherifa A Hamed et al
author_facet	Ghaydaa A Shehata Abd El-aziz M Bateh Sherifa A Hamed et al
author_sort	Ghaydaa A Shehata
title	Neuropsychological effects of antiepileptic drugs (carbamazepine versus valproate) in adult males with epilepsy
title_short	Neuropsychological effects of antiepileptic drugs (carbamazepine versus valproate) in adult males with epilepsy
title_full	Neuropsychological effects of antiepileptic drugs (carbamazepine versus valproate) in adult males with epilepsy
title_fullStr	Neuropsychological effects of antiepileptic drugs (carbamazepine versus valproate) in adult males with epilepsy
title_full_unstemmed	Neuropsychological effects of antiepileptic drugs (carbamazepine versus valproate) in adult males with epilepsy
title_sort	neuropsychological effects of antiepileptic drugs (carbamazepine versus valproate) in adult males with epilepsy
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/2eaa75fb715a4d38b3837c6a074a3546
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Neuropsychological effects of antiepileptic drugs (carbamazepine versus valproate) in adult males with epilepsy

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