Quantitative trait locus mapping identifies the Gpnmb gene as a modifier of mouse macrophage lysosome function

Quantitative trait locus mapping identifies the Gpnmb gene as a modifier of mouse macrophage lysosome function

Abstract We have previously shown that the DBA/2J versus AKR/J mouse strain is associated with decreased autophagy-mediated lysosomal hydrolysis of cholesterol esters. Our objective was to determine differences in lysosome function in AKR/J and DBA/2J macrophages, and identify the responsible genes....

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Autores principales: Peggy Robinet, Brian Ritchey, Shuhui Wang Lorkowski, Alexander M. Alzayed, Sophia DeGeorgia, Eve Schodowski, C. Alicia Traughber, Jonathan D. Smith
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/2eadfff2977f44acae1459d96f9ec631
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