PRO-APOPTOTIC EFFECTS OF APPLE PROCYANIDINS IN HUMAN COLON CANCER CELLS AND THEIR DERIVED METASTATIC CELLS

Apples are a rich source of Procyanidins (Pcy) which are able to inhibit colon carcinogenesis in animal models, but the mechanisms through which this occurs are not well understood.The evidence obtained in our laboratory and by other researchers, which shows that Pcy trigger apoptosis through differ...

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Autores principales:	María E. MALDONADO C., Francis RAUL
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2010
Materias:	apoptosis cáncer de colon flavonoides TRAIL Fas. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/2eae8c788a524b5b89a68787ff8a6de4
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spelling	oai:doaj.org-article:2eae8c788a524b5b89a68787ff8a6de42021-11-19T04:14:13ZPRO-APOPTOTIC EFFECTS OF APPLE PROCYANIDINS IN HUMAN COLON CANCER CELLS AND THEIR DERIVED METASTATIC CELLS0121-40042145-2660https://doaj.org/article/2eae8c788a524b5b89a68787ff8a6de42010-11-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/7443https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660Apples are a rich source of Procyanidins (Pcy) which are able to inhibit colon carcinogenesis in animal models, but the mechanisms through which this occurs are not well understood.The evidence obtained in our laboratory and by other researchers, which shows that Pcy trigger apoptosis through different mechanisms in human colon adenocarcinoma SW480 cells and their derived metastatic SW620 cells is reviewed in this paper. In the apoptosis induced by Pcy, the polyamine metabolism is involved, but it is not present in SW480 cells. There is a differential sensitivity of both cells lines to the activation of TRAIL-death receptors. Pcy enhance the sensitivity of SW480 cells to TRAIL by activating the extrinsic apoptotic pathway, and overcome TRAIL-resistance in SW620 cells involving a cross-talk between the extrinsic and intrinsic pathways; and a Pcy-induced ROS production favoring mitochondria disruption. In addition, Pcy activate Fas receptor in SW480 cells, whereas SW620 cells are Fas-resistant despite the up-regulated Fas expression. Surprisingly, activation of the Fas receptor-mediated apoptosis by Pcy is observed in SW620 cells after inactivation of TRAIL-death receptors, suggesting that Fas-resistant phenotype may be associated with alterations in downstream events between TRAIL-death and Fas receptors. These data highlight the potential interest of apple Pcy in colon cancer prevention and therapy (combination therapy).María E. MALDONADO C.Francis RAULUniversidad de Antioquiaarticleapoptosiscáncer de colonflavonoidesTRAILFas.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 17, Iss 3 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	apoptosis cáncer de colon flavonoides TRAIL Fas. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	apoptosis cáncer de colon flavonoides TRAIL Fas. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 María E. MALDONADO C. Francis RAUL PRO-APOPTOTIC EFFECTS OF APPLE PROCYANIDINS IN HUMAN COLON CANCER CELLS AND THEIR DERIVED METASTATIC CELLS
description	Apples are a rich source of Procyanidins (Pcy) which are able to inhibit colon carcinogenesis in animal models, but the mechanisms through which this occurs are not well understood.The evidence obtained in our laboratory and by other researchers, which shows that Pcy trigger apoptosis through different mechanisms in human colon adenocarcinoma SW480 cells and their derived metastatic SW620 cells is reviewed in this paper. In the apoptosis induced by Pcy, the polyamine metabolism is involved, but it is not present in SW480 cells. There is a differential sensitivity of both cells lines to the activation of TRAIL-death receptors. Pcy enhance the sensitivity of SW480 cells to TRAIL by activating the extrinsic apoptotic pathway, and overcome TRAIL-resistance in SW620 cells involving a cross-talk between the extrinsic and intrinsic pathways; and a Pcy-induced ROS production favoring mitochondria disruption. In addition, Pcy activate Fas receptor in SW480 cells, whereas SW620 cells are Fas-resistant despite the up-regulated Fas expression. Surprisingly, activation of the Fas receptor-mediated apoptosis by Pcy is observed in SW620 cells after inactivation of TRAIL-death receptors, suggesting that Fas-resistant phenotype may be associated with alterations in downstream events between TRAIL-death and Fas receptors. These data highlight the potential interest of apple Pcy in colon cancer prevention and therapy (combination therapy).
format	article
author	María E. MALDONADO C. Francis RAUL
author_facet	María E. MALDONADO C. Francis RAUL
author_sort	María E. MALDONADO C.
title	PRO-APOPTOTIC EFFECTS OF APPLE PROCYANIDINS IN HUMAN COLON CANCER CELLS AND THEIR DERIVED METASTATIC CELLS
title_short	PRO-APOPTOTIC EFFECTS OF APPLE PROCYANIDINS IN HUMAN COLON CANCER CELLS AND THEIR DERIVED METASTATIC CELLS
title_full	PRO-APOPTOTIC EFFECTS OF APPLE PROCYANIDINS IN HUMAN COLON CANCER CELLS AND THEIR DERIVED METASTATIC CELLS
title_fullStr	PRO-APOPTOTIC EFFECTS OF APPLE PROCYANIDINS IN HUMAN COLON CANCER CELLS AND THEIR DERIVED METASTATIC CELLS
title_full_unstemmed	PRO-APOPTOTIC EFFECTS OF APPLE PROCYANIDINS IN HUMAN COLON CANCER CELLS AND THEIR DERIVED METASTATIC CELLS
title_sort	pro-apoptotic effects of apple procyanidins in human colon cancer cells and their derived metastatic cells
publisher	Universidad de Antioquia
publishDate	2010
url	https://doaj.org/article/2eae8c788a524b5b89a68787ff8a6de4
work_keys_str_mv	AT mariaemaldonadoc proapoptoticeffectsofappleprocyanidinsinhumancoloncancercellsandtheirderivedmetastaticcells AT francisraul proapoptoticeffectsofappleprocyanidinsinhumancoloncancercellsandtheirderivedmetastaticcells
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PRO-APOPTOTIC EFFECTS OF APPLE PROCYANIDINS IN HUMAN COLON CANCER CELLS AND THEIR DERIVED METASTATIC CELLS

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