Molecular basis of V-ATPase inhibition by bafilomycin A1

Bafilomycin A1, a member of macrolide antibiotics and an autophagy inhibitor, serves as a specific and potent V-ATPases inhibitor. Here authors report the cryo-EM structure of bafilomycin A1-bound V-ATPase with six bafilomycin A1 molecules bound to the c-ring and reveal the molecular basis for Bafil...

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Autores principales:	Rong Wang, Jin Wang, Abdirahman Hassan, Chia-Hsueh Lee, Xiao-Song Xie, Xiaochun Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2eaf386808f9439ab039a8de36118ff2
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spelling	oai:doaj.org-article:2eaf386808f9439ab039a8de36118ff22021-12-02T11:39:31ZMolecular basis of V-ATPase inhibition by bafilomycin A110.1038/s41467-021-22111-52041-1723https://doaj.org/article/2eaf386808f9439ab039a8de36118ff22021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22111-5https://doaj.org/toc/2041-1723Bafilomycin A1, a member of macrolide antibiotics and an autophagy inhibitor, serves as a specific and potent V-ATPases inhibitor. Here authors report the cryo-EM structure of bafilomycin A1-bound V-ATPase with six bafilomycin A1 molecules bound to the c-ring and reveal the molecular basis for Bafilomycin A1 inhibition of the V-ATPase.Rong WangJin WangAbdirahman HassanChia-Hsueh LeeXiao-Song XieXiaochun LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rong Wang Jin Wang Abdirahman Hassan Chia-Hsueh Lee Xiao-Song Xie Xiaochun Li Molecular basis of V-ATPase inhibition by bafilomycin A1
description	Bafilomycin A1, a member of macrolide antibiotics and an autophagy inhibitor, serves as a specific and potent V-ATPases inhibitor. Here authors report the cryo-EM structure of bafilomycin A1-bound V-ATPase with six bafilomycin A1 molecules bound to the c-ring and reveal the molecular basis for Bafilomycin A1 inhibition of the V-ATPase.
format	article
author	Rong Wang Jin Wang Abdirahman Hassan Chia-Hsueh Lee Xiao-Song Xie Xiaochun Li
author_facet	Rong Wang Jin Wang Abdirahman Hassan Chia-Hsueh Lee Xiao-Song Xie Xiaochun Li
author_sort	Rong Wang
title	Molecular basis of V-ATPase inhibition by bafilomycin A1
title_short	Molecular basis of V-ATPase inhibition by bafilomycin A1
title_full	Molecular basis of V-ATPase inhibition by bafilomycin A1
title_fullStr	Molecular basis of V-ATPase inhibition by bafilomycin A1
title_full_unstemmed	Molecular basis of V-ATPase inhibition by bafilomycin A1
title_sort	molecular basis of v-atpase inhibition by bafilomycin a1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2eaf386808f9439ab039a8de36118ff2
work_keys_str_mv	AT rongwang molecularbasisofvatpaseinhibitionbybafilomycina1 AT jinwang molecularbasisofvatpaseinhibitionbybafilomycina1 AT abdirahmanhassan molecularbasisofvatpaseinhibitionbybafilomycina1 AT chiahsuehlee molecularbasisofvatpaseinhibitionbybafilomycina1 AT xiaosongxie molecularbasisofvatpaseinhibitionbybafilomycina1 AT xiaochunli molecularbasisofvatpaseinhibitionbybafilomycina1
_version_	1718395693025984512

Molecular basis of V-ATPase inhibition by bafilomycin A1

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