Memory-type ST2+CD4+ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia

Abstract The lung develops an unique epithelial barrier system to protect host from continuous invasion of various harmful particles. Interleukin (IL-)33 released from epithelial cells in the lung drives the type 2 immune response by activating ST2− expressed immune cells in various allergic disease...

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Autores principales:	Naoko Mato, Kiyoshi Hirahara, Tomomi Ichikawa, Jin Kumagai, Masayuki Nakayama, Hideaki Yamasawa, Masashi Bando, Koichi Hagiwara, Yukihiko Sugiyama, Toshinori Nakayama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2eb04efcf4344664b2be1cd43da9c946
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spelling	oai:doaj.org-article:2eb04efcf4344664b2be1cd43da9c9462021-12-02T16:07:58ZMemory-type ST2+CD4+ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia10.1038/s41598-017-06962-x2045-2322https://doaj.org/article/2eb04efcf4344664b2be1cd43da9c9462017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06962-xhttps://doaj.org/toc/2045-2322Abstract The lung develops an unique epithelial barrier system to protect host from continuous invasion of various harmful particles. Interleukin (IL-)33 released from epithelial cells in the lung drives the type 2 immune response by activating ST2− expressed immune cells in various allergic diseases. However, the involvement of memory-type ST2+CD4+ T cells in such lung inflammation remains unclear. Here we demonstrated that intratracheal administration of IL-33 resulted in the substantial increase of numbers of tissue-resident memory-type ST2+CD4+ T cells in the lung. Following enhanced production of IL-5 and IL-13, eosinophilic lung inflammation sequentially developed. IL-33-mediated eosinophilic lung inflammation was not fully developed in T cell-deficient Foxn1 nu mice and NSG mice. Dexamethasone treatment showed limited effects on both the cell number and function of memory-type ST2+CD4+ T cells. Thus our study provides novel insight into the pathogenesis of eosinophilic lung disease, showing that memory-type ST2+CD4+ T cells are involved in IL-33-induced eosinophilic inflammation and elicited steroid-resistance.Naoko MatoKiyoshi HiraharaTomomi IchikawaJin KumagaiMasayuki NakayamaHideaki YamasawaMasashi BandoKoichi HagiwaraYukihiko SugiyamaToshinori NakayamaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Naoko Mato Kiyoshi Hirahara Tomomi Ichikawa Jin Kumagai Masayuki Nakayama Hideaki Yamasawa Masashi Bando Koichi Hagiwara Yukihiko Sugiyama Toshinori Nakayama Memory-type ST2+CD4+ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia
description	Abstract The lung develops an unique epithelial barrier system to protect host from continuous invasion of various harmful particles. Interleukin (IL-)33 released from epithelial cells in the lung drives the type 2 immune response by activating ST2− expressed immune cells in various allergic diseases. However, the involvement of memory-type ST2+CD4+ T cells in such lung inflammation remains unclear. Here we demonstrated that intratracheal administration of IL-33 resulted in the substantial increase of numbers of tissue-resident memory-type ST2+CD4+ T cells in the lung. Following enhanced production of IL-5 and IL-13, eosinophilic lung inflammation sequentially developed. IL-33-mediated eosinophilic lung inflammation was not fully developed in T cell-deficient Foxn1 nu mice and NSG mice. Dexamethasone treatment showed limited effects on both the cell number and function of memory-type ST2+CD4+ T cells. Thus our study provides novel insight into the pathogenesis of eosinophilic lung disease, showing that memory-type ST2+CD4+ T cells are involved in IL-33-induced eosinophilic inflammation and elicited steroid-resistance.
format	article
author	Naoko Mato Kiyoshi Hirahara Tomomi Ichikawa Jin Kumagai Masayuki Nakayama Hideaki Yamasawa Masashi Bando Koichi Hagiwara Yukihiko Sugiyama Toshinori Nakayama
author_facet	Naoko Mato Kiyoshi Hirahara Tomomi Ichikawa Jin Kumagai Masayuki Nakayama Hideaki Yamasawa Masashi Bando Koichi Hagiwara Yukihiko Sugiyama Toshinori Nakayama
author_sort	Naoko Mato
title	Memory-type ST2+CD4+ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia
title_short	Memory-type ST2+CD4+ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia
title_full	Memory-type ST2+CD4+ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia
title_fullStr	Memory-type ST2+CD4+ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia
title_full_unstemmed	Memory-type ST2+CD4+ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia
title_sort	memory-type st2+cd4+ t cells participate in the steroid-resistant pathology of eosinophilic pneumonia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2eb04efcf4344664b2be1cd43da9c946
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_version_	1718384644500488192

Memory-type ST2+CD4+ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia

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