Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5

The authors show that post-transcriptional regulation of the cilia-driven leftward flow target dand5 is central to symmetry breakage in frog, fish and mouse and is mediated by a 139 nt Bicc1 responsive element in the dand5 3′UTR, and they present evidence that Pkd2 regulates this Bicc1/dand5 module....

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Autores principales:	Markus Maerker, Maike Getwan, Megan E. Dowdle, Jason C. McSheene, Vanessa Gonzalez, José L. Pelliccia, Danielle S. Hamilton, Valeria Yartseva, Charles Vejnar, Melanie Tingler, Katsura Minegishi, Philipp Vick, Antonio J. Giraldez, Hiroshi Hamada, Rebecca D. Burdine, Michael D. Sheets, Martin Blum, Axel Schweickert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2eb07da85f2e46aaa1d04d13bd6e2bee
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spelling	oai:doaj.org-article:2eb07da85f2e46aaa1d04d13bd6e2bee2021-12-02T17:23:40ZBicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand510.1038/s41467-021-25464-z2041-1723https://doaj.org/article/2eb07da85f2e46aaa1d04d13bd6e2bee2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25464-zhttps://doaj.org/toc/2041-1723The authors show that post-transcriptional regulation of the cilia-driven leftward flow target dand5 is central to symmetry breakage in frog, fish and mouse and is mediated by a 139 nt Bicc1 responsive element in the dand5 3′UTR, and they present evidence that Pkd2 regulates this Bicc1/dand5 module.Markus MaerkerMaike GetwanMegan E. DowdleJason C. McSheeneVanessa GonzalezJosé L. PellicciaDanielle S. HamiltonValeria YartsevaCharles VejnarMelanie TinglerKatsura MinegishiPhilipp VickAntonio J. GiraldezHiroshi HamadaRebecca D. BurdineMichael D. SheetsMartin BlumAxel SchweickertNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Markus Maerker Maike Getwan Megan E. Dowdle Jason C. McSheene Vanessa Gonzalez José L. Pelliccia Danielle S. Hamilton Valeria Yartseva Charles Vejnar Melanie Tingler Katsura Minegishi Philipp Vick Antonio J. Giraldez Hiroshi Hamada Rebecca D. Burdine Michael D. Sheets Martin Blum Axel Schweickert Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5
description	The authors show that post-transcriptional regulation of the cilia-driven leftward flow target dand5 is central to symmetry breakage in frog, fish and mouse and is mediated by a 139 nt Bicc1 responsive element in the dand5 3′UTR, and they present evidence that Pkd2 regulates this Bicc1/dand5 module.
format	article
author	Markus Maerker Maike Getwan Megan E. Dowdle Jason C. McSheene Vanessa Gonzalez José L. Pelliccia Danielle S. Hamilton Valeria Yartseva Charles Vejnar Melanie Tingler Katsura Minegishi Philipp Vick Antonio J. Giraldez Hiroshi Hamada Rebecca D. Burdine Michael D. Sheets Martin Blum Axel Schweickert
author_facet	Markus Maerker Maike Getwan Megan E. Dowdle Jason C. McSheene Vanessa Gonzalez José L. Pelliccia Danielle S. Hamilton Valeria Yartseva Charles Vejnar Melanie Tingler Katsura Minegishi Philipp Vick Antonio J. Giraldez Hiroshi Hamada Rebecca D. Burdine Michael D. Sheets Martin Blum Axel Schweickert
author_sort	Markus Maerker
title	Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5
title_short	Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5
title_full	Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5
title_fullStr	Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5
title_full_unstemmed	Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5
title_sort	bicc1 and dicer regulate left-right patterning through post-transcriptional control of the nodal inhibitor dand5
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2eb07da85f2e46aaa1d04d13bd6e2bee
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Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5

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