Isolation-Induced Ultrasonic Vocalization in Environmental and Genetic Mice Models of Autism

Studies in rodent models suggest that calls emitted by isolated pups serve as an early behavioral manifestation of communication deficits and autistic like behavior. Previous studies in our labs showed that gestational exposure to the pesticide chlorpyrifos (CPF) and the Mthfr-knock-out mice are ass...

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Autores principales:	Itay Shekel, Shaked Giladi, Eynav Raykin, May Weiner, Vered Chalifa-Caspi, Dror Lederman, Ora Kofman, Hava M. Golan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	autism MTHFR chlorpyrifos GABA ultrasonic vocalization communication Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/2eb0f174c9934c3ba3a1a53fc8fbc456
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spelling	oai:doaj.org-article:2eb0f174c9934c3ba3a1a53fc8fbc4562021-11-22T05:25:16ZIsolation-Induced Ultrasonic Vocalization in Environmental and Genetic Mice Models of Autism1662-453X10.3389/fnins.2021.769670https://doaj.org/article/2eb0f174c9934c3ba3a1a53fc8fbc4562021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.769670/fullhttps://doaj.org/toc/1662-453XStudies in rodent models suggest that calls emitted by isolated pups serve as an early behavioral manifestation of communication deficits and autistic like behavior. Previous studies in our labs showed that gestational exposure to the pesticide chlorpyrifos (CPF) and the Mthfr-knock-out mice are associated with impaired social preference and restricted or repetitive behavior. To extend these studies, we examine how pup communication via ultrasonic vocalizations is altered in these ASD models. We implemented an unsupervised hierarchical clustering method based on the spectral properties of the syllables in order to exploit syllable classification to homogeneous categories while avoiding over-categorization. Comparative exploration of the spectral and temporal aspects of syllables emitted by pups in two ASD models point to the following: (1) Most clusters showed a significant effect of the ASD factor on the start and end frequencies and bandwidth and (2) The highest percent change due to the ASD factor was on the bandwidth and duration. In addition, we found sex differences in the spectral and temporal properties of the calls in both control groups as well as an interaction between sex and the gene/environment factor. Considering the basal differences in the characteristics of syllables emitted by pups of the C57Bl/6 and Balb/c strains used as a background in the two models, we suggest that the above spectral-temporal parameters start frequency, bandwidth, and duration are the most sensitive USV features that may represent developmental changes in ASD models.Itay ShekelItay ShekelShaked GiladiEynav RaykinEynav RaykinMay WeinerVered Chalifa-CaspiDror LedermanOra KofmanOra KofmanHava M. GolanHava M. GolanHava M. GolanFrontiers Media S.A.articleautismMTHFRchlorpyrifosGABAultrasonic vocalizationcommunicationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autism MTHFR chlorpyrifos GABA ultrasonic vocalization communication Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	autism MTHFR chlorpyrifos GABA ultrasonic vocalization communication Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Itay Shekel Itay Shekel Shaked Giladi Eynav Raykin Eynav Raykin May Weiner Vered Chalifa-Caspi Dror Lederman Ora Kofman Ora Kofman Hava M. Golan Hava M. Golan Hava M. Golan Isolation-Induced Ultrasonic Vocalization in Environmental and Genetic Mice Models of Autism
description	Studies in rodent models suggest that calls emitted by isolated pups serve as an early behavioral manifestation of communication deficits and autistic like behavior. Previous studies in our labs showed that gestational exposure to the pesticide chlorpyrifos (CPF) and the Mthfr-knock-out mice are associated with impaired social preference and restricted or repetitive behavior. To extend these studies, we examine how pup communication via ultrasonic vocalizations is altered in these ASD models. We implemented an unsupervised hierarchical clustering method based on the spectral properties of the syllables in order to exploit syllable classification to homogeneous categories while avoiding over-categorization. Comparative exploration of the spectral and temporal aspects of syllables emitted by pups in two ASD models point to the following: (1) Most clusters showed a significant effect of the ASD factor on the start and end frequencies and bandwidth and (2) The highest percent change due to the ASD factor was on the bandwidth and duration. In addition, we found sex differences in the spectral and temporal properties of the calls in both control groups as well as an interaction between sex and the gene/environment factor. Considering the basal differences in the characteristics of syllables emitted by pups of the C57Bl/6 and Balb/c strains used as a background in the two models, we suggest that the above spectral-temporal parameters start frequency, bandwidth, and duration are the most sensitive USV features that may represent developmental changes in ASD models.
format	article
author	Itay Shekel Itay Shekel Shaked Giladi Eynav Raykin Eynav Raykin May Weiner Vered Chalifa-Caspi Dror Lederman Ora Kofman Ora Kofman Hava M. Golan Hava M. Golan Hava M. Golan
author_facet	Itay Shekel Itay Shekel Shaked Giladi Eynav Raykin Eynav Raykin May Weiner Vered Chalifa-Caspi Dror Lederman Ora Kofman Ora Kofman Hava M. Golan Hava M. Golan Hava M. Golan
author_sort	Itay Shekel
title	Isolation-Induced Ultrasonic Vocalization in Environmental and Genetic Mice Models of Autism
title_short	Isolation-Induced Ultrasonic Vocalization in Environmental and Genetic Mice Models of Autism
title_full	Isolation-Induced Ultrasonic Vocalization in Environmental and Genetic Mice Models of Autism
title_fullStr	Isolation-Induced Ultrasonic Vocalization in Environmental and Genetic Mice Models of Autism
title_full_unstemmed	Isolation-Induced Ultrasonic Vocalization in Environmental and Genetic Mice Models of Autism
title_sort	isolation-induced ultrasonic vocalization in environmental and genetic mice models of autism
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2eb0f174c9934c3ba3a1a53fc8fbc456
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Isolation-Induced Ultrasonic Vocalization in Environmental and Genetic Mice Models of Autism

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