Guillain-Barré Syndrome, Influenza Vaccination, and Antecedent Respiratory and Gastrointestinal Infections: A Case-Centered Analysis in the Vaccine Safety Datalink, 2009-2011.

<h4>Background</h4>Guillain-Barré Syndrome (GBS) can be triggered by gastrointestinal or respiratory infections, including influenza. During the 2009 influenza A (H1N1) pandemic in the United States, monovalent inactivated influenza vaccine (MIV) availability coincided with high rates of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sharon K Greene, Melisa D Rett, Claudia Vellozzi, Lingling Li, Martin Kulldorff, S Michael Marcy, Matthew F Daley, Edward A Belongia, Roger Baxter, Bruce H Fireman, Michael L Jackson, Saad B Omer, James D Nordin, Robert Jin, Eric S Weintraub, Vinutha Vijayadeva, Grace M Lee
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2eb22957a6544326ae06197c0f046cdb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2eb22957a6544326ae06197c0f046cdb
record_format	dspace
spelling	oai:doaj.org-article:2eb22957a6544326ae06197c0f046cdb2021-11-18T07:39:52ZGuillain-Barré Syndrome, Influenza Vaccination, and Antecedent Respiratory and Gastrointestinal Infections: A Case-Centered Analysis in the Vaccine Safety Datalink, 2009-2011.1932-620310.1371/journal.pone.0067185https://doaj.org/article/2eb22957a6544326ae06197c0f046cdb2013-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0067185https://doaj.org/toc/1932-6203<h4>Background</h4>Guillain-Barré Syndrome (GBS) can be triggered by gastrointestinal or respiratory infections, including influenza. During the 2009 influenza A (H1N1) pandemic in the United States, monovalent inactivated influenza vaccine (MIV) availability coincided with high rates of wildtype influenza infections. Several prior studies suggested an elevated GBS risk following MIV, but adjustment for antecedent infection was limited.<h4>Methods</h4>We identified patients enrolled in health plans participating in the Vaccine Safety Datalink and diagnosed with GBS from July 2009 through June 2011. Medical records of GBS cases with 2009-10 MIV, 2010-11 trivalent inactivated influenza vaccine (TIV), and/or a medically-attended respiratory or gastrointestinal infection in the 1 through 141 days prior to GBS diagnosis were reviewed and classified according to Brighton Collaboration criteria for diagnostic certainty. Using a case-centered design, logistic regression models adjusted for patient-level time-varying sources of confounding, including seasonal vaccinations and infections in GBS cases and population-level controls.<h4>Results</h4>Eighteen confirmed GBS cases received vaccination in the 6 weeks preceding onset, among 1.27 million 2009-10 MIV recipients and 2.80 million 2010-11 TIV recipients. Forty-four confirmed GBS cases had infection in the 6 weeks preceding onset, among 3.77 million patients diagnosed with medically-attended infection. The observed-versus-expected odds that 2009-10 MIV/2010-11 TIV was received in the 6 weeks preceding GBS onset was odds ratio = 1.54, 95% confidence interval (CI), 0.59-3.99; risk difference = 0.93 per million doses, 95% CI, -0.71-5.16. The association between GBS and medically-attended infection was: odds ratio = 7.73, 95% CI, 3.60-16.61; risk difference = 11.62 per million infected patients, 95% CI, 4.49-26.94. These findings were consistent in sensitivity analyses using alternative infection definitions and risk intervals for prior vaccination shorter than 6 weeks.<h4>Conclusions</h4>After adjusting for antecedent infections, we found no evidence for an elevated GBS risk following 2009-10 MIV/2010-11 TIV influenza vaccines. However, the association between GBS and antecedent infection was strongly elevated.Sharon K GreeneMelisa D RettClaudia VellozziLingling LiMartin KulldorffS Michael MarcyMatthew F DaleyEdward A BelongiaRoger BaxterBruce H FiremanMichael L JacksonSaad B OmerJames D NordinRobert JinEric S WeintraubVinutha VijayadevaGrace M LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e67185 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sharon K Greene Melisa D Rett Claudia Vellozzi Lingling Li Martin Kulldorff S Michael Marcy Matthew F Daley Edward A Belongia Roger Baxter Bruce H Fireman Michael L Jackson Saad B Omer James D Nordin Robert Jin Eric S Weintraub Vinutha Vijayadeva Grace M Lee Guillain-Barré Syndrome, Influenza Vaccination, and Antecedent Respiratory and Gastrointestinal Infections: A Case-Centered Analysis in the Vaccine Safety Datalink, 2009-2011.
description	<h4>Background</h4>Guillain-Barré Syndrome (GBS) can be triggered by gastrointestinal or respiratory infections, including influenza. During the 2009 influenza A (H1N1) pandemic in the United States, monovalent inactivated influenza vaccine (MIV) availability coincided with high rates of wildtype influenza infections. Several prior studies suggested an elevated GBS risk following MIV, but adjustment for antecedent infection was limited.<h4>Methods</h4>We identified patients enrolled in health plans participating in the Vaccine Safety Datalink and diagnosed with GBS from July 2009 through June 2011. Medical records of GBS cases with 2009-10 MIV, 2010-11 trivalent inactivated influenza vaccine (TIV), and/or a medically-attended respiratory or gastrointestinal infection in the 1 through 141 days prior to GBS diagnosis were reviewed and classified according to Brighton Collaboration criteria for diagnostic certainty. Using a case-centered design, logistic regression models adjusted for patient-level time-varying sources of confounding, including seasonal vaccinations and infections in GBS cases and population-level controls.<h4>Results</h4>Eighteen confirmed GBS cases received vaccination in the 6 weeks preceding onset, among 1.27 million 2009-10 MIV recipients and 2.80 million 2010-11 TIV recipients. Forty-four confirmed GBS cases had infection in the 6 weeks preceding onset, among 3.77 million patients diagnosed with medically-attended infection. The observed-versus-expected odds that 2009-10 MIV/2010-11 TIV was received in the 6 weeks preceding GBS onset was odds ratio = 1.54, 95% confidence interval (CI), 0.59-3.99; risk difference = 0.93 per million doses, 95% CI, -0.71-5.16. The association between GBS and medically-attended infection was: odds ratio = 7.73, 95% CI, 3.60-16.61; risk difference = 11.62 per million infected patients, 95% CI, 4.49-26.94. These findings were consistent in sensitivity analyses using alternative infection definitions and risk intervals for prior vaccination shorter than 6 weeks.<h4>Conclusions</h4>After adjusting for antecedent infections, we found no evidence for an elevated GBS risk following 2009-10 MIV/2010-11 TIV influenza vaccines. However, the association between GBS and antecedent infection was strongly elevated.
format	article
author	Sharon K Greene Melisa D Rett Claudia Vellozzi Lingling Li Martin Kulldorff S Michael Marcy Matthew F Daley Edward A Belongia Roger Baxter Bruce H Fireman Michael L Jackson Saad B Omer James D Nordin Robert Jin Eric S Weintraub Vinutha Vijayadeva Grace M Lee
author_facet	Sharon K Greene Melisa D Rett Claudia Vellozzi Lingling Li Martin Kulldorff S Michael Marcy Matthew F Daley Edward A Belongia Roger Baxter Bruce H Fireman Michael L Jackson Saad B Omer James D Nordin Robert Jin Eric S Weintraub Vinutha Vijayadeva Grace M Lee
author_sort	Sharon K Greene
title	Guillain-Barré Syndrome, Influenza Vaccination, and Antecedent Respiratory and Gastrointestinal Infections: A Case-Centered Analysis in the Vaccine Safety Datalink, 2009-2011.
title_short	Guillain-Barré Syndrome, Influenza Vaccination, and Antecedent Respiratory and Gastrointestinal Infections: A Case-Centered Analysis in the Vaccine Safety Datalink, 2009-2011.
title_full	Guillain-Barré Syndrome, Influenza Vaccination, and Antecedent Respiratory and Gastrointestinal Infections: A Case-Centered Analysis in the Vaccine Safety Datalink, 2009-2011.
title_fullStr	Guillain-Barré Syndrome, Influenza Vaccination, and Antecedent Respiratory and Gastrointestinal Infections: A Case-Centered Analysis in the Vaccine Safety Datalink, 2009-2011.
title_full_unstemmed	Guillain-Barré Syndrome, Influenza Vaccination, and Antecedent Respiratory and Gastrointestinal Infections: A Case-Centered Analysis in the Vaccine Safety Datalink, 2009-2011.
title_sort	guillain-barré syndrome, influenza vaccination, and antecedent respiratory and gastrointestinal infections: a case-centered analysis in the vaccine safety datalink, 2009-2011.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/2eb22957a6544326ae06197c0f046cdb
work_keys_str_mv	AT sharonkgreene guillainbarresyndromeinfluenzavaccinationandantecedentrespiratoryandgastrointestinalinfectionsacasecenteredanalysisinthevaccinesafetydatalink20092011 AT melisadrett guillainbarresyndromeinfluenzavaccinationandantecedentrespiratoryandgastrointestinalinfectionsacasecenteredanalysisinthevaccinesafetydatalink20092011 AT claudiavellozzi guillainbarresyndromeinfluenzavaccinationandantecedentrespiratoryandgastrointestinalinfectionsacasecenteredanalysisinthevaccinesafetydatalink20092011 AT linglingli guillainbarresyndromeinfluenzavaccinationandantecedentrespiratoryandgastrointestinalinfectionsacasecenteredanalysisinthevaccinesafetydatalink20092011 AT martinkulldorff guillainbarresyndromeinfluenzavaccinationandantecedentrespiratoryandgastrointestinalinfectionsacasecenteredanalysisinthevaccinesafetydatalink20092011 AT smichaelmarcy guillainbarresyndromeinfluenzavaccinationandantecedentrespiratoryandgastrointestinalinfectionsacasecenteredanalysisinthevaccinesafetydatalink20092011 AT matthewfdaley guillainbarresyndromeinfluenzavaccinationandantecedentrespiratoryandgastrointestinalinfectionsacasecenteredanalysisinthevaccinesafetydatalink20092011 AT edwardabelongia guillainbarresyndromeinfluenzavaccinationandantecedentrespiratoryandgastrointestinalinfectionsacasecenteredanalysisinthevaccinesafetydatalink20092011 AT rogerbaxter guillainbarresyndromeinfluenzavaccinationandantecedentrespiratoryandgastrointestinalinfectionsacasecenteredanalysisinthevaccinesafetydatalink20092011 AT brucehfireman guillainbarresyndromeinfluenzavaccinationandantecedentrespiratoryandgastrointestinalinfectionsacasecenteredanalysisinthevaccinesafetydatalink20092011 AT michaelljackson guillainbarresyndromeinfluenzavaccinationandantecedentrespiratoryandgastrointestinalinfectionsacasecenteredanalysisinthevaccinesafetydatalink20092011 AT saadbomer guillainbarresyndromeinfluenzavaccinationandantecedentrespiratoryandgastrointestinalinfectionsacasecenteredanalysisinthevaccinesafetydatalink20092011 AT jamesdnordin guillainbarresyndromeinfluenzavaccinationandantecedentrespiratoryandgastrointestinalinfectionsacasecenteredanalysisinthevaccinesafetydatalink20092011 AT robertjin guillainbarresyndromeinfluenzavaccinationandantecedentrespiratoryandgastrointestinalinfectionsacasecenteredanalysisinthevaccinesafetydatalink20092011 AT ericsweintraub guillainbarresyndromeinfluenzavaccinationandantecedentrespiratoryandgastrointestinalinfectionsacasecenteredanalysisinthevaccinesafetydatalink20092011 AT vinuthavijayadeva guillainbarresyndromeinfluenzavaccinationandantecedentrespiratoryandgastrointestinalinfectionsacasecenteredanalysisinthevaccinesafetydatalink20092011 AT gracemlee guillainbarresyndromeinfluenzavaccinationandantecedentrespiratoryandgastrointestinalinfectionsacasecenteredanalysisinthevaccinesafetydatalink20092011
_version_	1718423088469639168

Guillain-Barré Syndrome, Influenza Vaccination, and Antecedent Respiratory and Gastrointestinal Infections: A Case-Centered Analysis in the Vaccine Safety Datalink, 2009-2011.

Ejemplares similares