Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds

Ranjith Kumar Kankala,1–3,* Biao-Qi Chen,1,2,* Chen-Guang Liu,1,2 Han-Xiao Tang,1,2 Shi-Bin Wang,1–3 Ai-Zheng Chen1–3 1College of Chemical Engineering, Huaqiao University, Xiamen, People’s Republic of China; 2Institute of Biomaterials and Tissue Engineering,...

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Autores principales:	Kankala RK, Chen BQ, Liu CG, Tang HX, Wang SB, Chen AZ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Supercritical fluids Anti-solvent Nanonization Drug delivery Polymeric carriers Parameters effect. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2eb2daae62094e18a96af2958fc676a1
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spelling	oai:doaj.org-article:2eb2daae62094e18a96af2958fc676a12021-12-02T00:52:39ZSolution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds1178-2013https://doaj.org/article/2eb2daae62094e18a96af2958fc676a12018-07-01T00:00:00Zhttps://www.dovepress.com/solution-enhanced-dispersion-by-supercritical-fluids-an-ecofriendly-na-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ranjith Kumar Kankala,1–3,* Biao-Qi Chen,1,2,* Chen-Guang Liu,1,2 Han-Xiao Tang,1,2 Shi-Bin Wang,1–3 Ai-Zheng Chen1–3 1College of Chemical Engineering, Huaqiao University, Xiamen, People’s Republic of China; 2Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen, People’s Republic of China; 3Fujian Provincial Key Laboratory of Biochemical Technology (Huaqiao University), Xiamen, People’s Republic of China *These authors contributed equally to this work Abstract: In recent years, the supercritical fluid (SCF) technology has attracted enormous interest from researchers over the traditional pharmaceutical manufacturing strategies due to the environmentally benign nature and economically promising character of SCFs. Among all the SCF-assisted processes for particle formation, the solution-enhanced dispersion by supercritical fluids (SEDS) process is perhaps one of the most efficient methods to fabricate the biomaterials and pharmaceutical compounds at an arbitrary gauge, ranging from micro- to nanoscale. The resultant miniature-sized particles from the SEDS process offer enhanced features concerning their physical attributes such as bioavailability enhancement due to their high surface area. First, we provide a brief description of SCFs and their behavior as an anti-solvent in SCF-assisted processing. Then, we aim to give a brief overview of the SEDS process as well as its modified prototypes, highlighting the pros and cons of the particular modification. We then emphasize the effects of various processing constraints such as temperature, pressure, SCF as well as organic solvents (if used) and their flow rates, and the concentration of drug/polymer, among others, on particle formation with respect to the particle size distribution, precipitation yield, and morphologic attributes. Next, we aim to systematically discuss the application of the SEDS technique in producing therapeutic nano-sized formulations by operating the drugs alone or in combination with the biodegradable polymers for the application focusing oral, pulmonary, and transdermal as well as implantable delivery with a set of examples. We finally summarize with perspectives. Keywords: controlled release, anti-solvent, nanonization, drug delivery, polymeric carriers, parameters effectKankala RKChen BQLiu CGTang HXWang SBChen AZDove Medical PressarticleSupercritical fluidsAnti-solventNanonizationDrug deliveryPolymeric carriersParameters effect.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 4227-4245 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Supercritical fluids Anti-solvent Nanonization Drug delivery Polymeric carriers Parameters effect. Medicine (General) R5-920
spellingShingle	Supercritical fluids Anti-solvent Nanonization Drug delivery Polymeric carriers Parameters effect. Medicine (General) R5-920 Kankala RK Chen BQ Liu CG Tang HX Wang SB Chen AZ Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds
description	Ranjith Kumar Kankala,1–3,* Biao-Qi Chen,1,2,* Chen-Guang Liu,1,2 Han-Xiao Tang,1,2 Shi-Bin Wang,1–3 Ai-Zheng Chen1–3 1College of Chemical Engineering, Huaqiao University, Xiamen, People’s Republic of China; 2Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen, People’s Republic of China; 3Fujian Provincial Key Laboratory of Biochemical Technology (Huaqiao University), Xiamen, People’s Republic of China *These authors contributed equally to this work Abstract: In recent years, the supercritical fluid (SCF) technology has attracted enormous interest from researchers over the traditional pharmaceutical manufacturing strategies due to the environmentally benign nature and economically promising character of SCFs. Among all the SCF-assisted processes for particle formation, the solution-enhanced dispersion by supercritical fluids (SEDS) process is perhaps one of the most efficient methods to fabricate the biomaterials and pharmaceutical compounds at an arbitrary gauge, ranging from micro- to nanoscale. The resultant miniature-sized particles from the SEDS process offer enhanced features concerning their physical attributes such as bioavailability enhancement due to their high surface area. First, we provide a brief description of SCFs and their behavior as an anti-solvent in SCF-assisted processing. Then, we aim to give a brief overview of the SEDS process as well as its modified prototypes, highlighting the pros and cons of the particular modification. We then emphasize the effects of various processing constraints such as temperature, pressure, SCF as well as organic solvents (if used) and their flow rates, and the concentration of drug/polymer, among others, on particle formation with respect to the particle size distribution, precipitation yield, and morphologic attributes. Next, we aim to systematically discuss the application of the SEDS technique in producing therapeutic nano-sized formulations by operating the drugs alone or in combination with the biodegradable polymers for the application focusing oral, pulmonary, and transdermal as well as implantable delivery with a set of examples. We finally summarize with perspectives. Keywords: controlled release, anti-solvent, nanonization, drug delivery, polymeric carriers, parameters effect
format	article
author	Kankala RK Chen BQ Liu CG Tang HX Wang SB Chen AZ
author_facet	Kankala RK Chen BQ Liu CG Tang HX Wang SB Chen AZ
author_sort	Kankala RK
title	Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds
title_short	Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds
title_full	Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds
title_fullStr	Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds
title_full_unstemmed	Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds
title_sort	solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/2eb2daae62094e18a96af2958fc676a1
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_version_	1718403429162811392

Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds

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