Weight loss medications in Canada – a new frontier or a repeat of past mistakes?

Sean Wharton,1,2 Jasmine Lee,1 Rebecca AG Christensen1 1The Wharton Medical Clinic, Hamilton, ON, Canada; 2School of Kinesiology and Health Science, York University, Toronto, ON, Canada Abstract: Current methods for the treatment of excess weight can involve healthy behavior changes, pharmacotherapy...

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Autores principales:	Wharton S, Lee J, Christensen RAG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	weight loss pharmacological intervention Liraglutide weight loss medication Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/2eb477387cd34c50be259074af4042b6
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spelling	oai:doaj.org-article:2eb477387cd34c50be259074af4042b62021-12-02T00:43:08ZWeight loss medications in Canada – a new frontier or a repeat of past mistakes?1178-7007https://doaj.org/article/2eb477387cd34c50be259074af4042b62017-10-01T00:00:00Zhttps://www.dovepress.com/weight-loss-medications-in-canada---a-new-frontier-or-a-repeat-of-past-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Sean Wharton,1,2 Jasmine Lee,1 Rebecca AG Christensen1 1The Wharton Medical Clinic, Hamilton, ON, Canada; 2School of Kinesiology and Health Science, York University, Toronto, ON, Canada Abstract: Current methods for the treatment of excess weight can involve healthy behavior changes, pharmacotherapy, and surgical interventions. Many individuals are able to lose some degree of weight through behavioral changes; however, they are often unable to maintain their weight loss long-term. This is in part due to physiological processes that cannot be addressed through behavioral changes alone. Bariatric surgery, which is the most successful treatment for excess weight to date, does result in physiological changes that can help with weight loss and weight maintenance. However, many patients either do not qualify or elect to not have this procedure. Fortunately, research has recently identified changes in neurochemicals (i.e., orexigens and anorexigens) that occur during weight loss and contribute to weight regain. The neurochemicals and hormones may be able to be targeted by medications to achieve greater and more sustained weight loss. Two medications are approved in adjunction to lifestyle management for weight loss in Canada: orlistat and liraglutide. Both medications are able to target physiological processes to help patients lose weight and maintain a greater amount of weight loss than with just behavioral modifications alone. Two other weight management medications, which also target specific physiological processes to aid in weight loss and its maintenance, a bupropion/naltrexone combination and lorcaserin, are currently pending approval in Canada. Nonetheless, there remain significant barriers for health care professionals to prescribe medications for weight loss, such as a lack of training and knowledge in the area of obesity. Until this has been addressed, and we begin treating obesity as we do other diseases, we are unlikely to combat the increasing trend of obesity in Canada and worldwide. Keywords: weight loss, pharmacological intervention, liraglutide, weight loss medicationWharton SLee JChristensen RAGDove Medical Pressarticleweight losspharmacological interventionLiraglutideweight loss medicationSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 10, Pp 413-417 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	weight loss pharmacological intervention Liraglutide weight loss medication Specialties of internal medicine RC581-951
spellingShingle	weight loss pharmacological intervention Liraglutide weight loss medication Specialties of internal medicine RC581-951 Wharton S Lee J Christensen RAG Weight loss medications in Canada – a new frontier or a repeat of past mistakes?
description	Sean Wharton,1,2 Jasmine Lee,1 Rebecca AG Christensen1 1The Wharton Medical Clinic, Hamilton, ON, Canada; 2School of Kinesiology and Health Science, York University, Toronto, ON, Canada Abstract: Current methods for the treatment of excess weight can involve healthy behavior changes, pharmacotherapy, and surgical interventions. Many individuals are able to lose some degree of weight through behavioral changes; however, they are often unable to maintain their weight loss long-term. This is in part due to physiological processes that cannot be addressed through behavioral changes alone. Bariatric surgery, which is the most successful treatment for excess weight to date, does result in physiological changes that can help with weight loss and weight maintenance. However, many patients either do not qualify or elect to not have this procedure. Fortunately, research has recently identified changes in neurochemicals (i.e., orexigens and anorexigens) that occur during weight loss and contribute to weight regain. The neurochemicals and hormones may be able to be targeted by medications to achieve greater and more sustained weight loss. Two medications are approved in adjunction to lifestyle management for weight loss in Canada: orlistat and liraglutide. Both medications are able to target physiological processes to help patients lose weight and maintain a greater amount of weight loss than with just behavioral modifications alone. Two other weight management medications, which also target specific physiological processes to aid in weight loss and its maintenance, a bupropion/naltrexone combination and lorcaserin, are currently pending approval in Canada. Nonetheless, there remain significant barriers for health care professionals to prescribe medications for weight loss, such as a lack of training and knowledge in the area of obesity. Until this has been addressed, and we begin treating obesity as we do other diseases, we are unlikely to combat the increasing trend of obesity in Canada and worldwide. Keywords: weight loss, pharmacological intervention, liraglutide, weight loss medication
format	article
author	Wharton S Lee J Christensen RAG
author_facet	Wharton S Lee J Christensen RAG
author_sort	Wharton S
title	Weight loss medications in Canada – a new frontier or a repeat of past mistakes?
title_short	Weight loss medications in Canada – a new frontier or a repeat of past mistakes?
title_full	Weight loss medications in Canada – a new frontier or a repeat of past mistakes?
title_fullStr	Weight loss medications in Canada – a new frontier or a repeat of past mistakes?
title_full_unstemmed	Weight loss medications in Canada – a new frontier or a repeat of past mistakes?
title_sort	weight loss medications in canada – a new frontier or a repeat of past mistakes?
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/2eb477387cd34c50be259074af4042b6
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Weight loss medications in Canada &ndash;&nbsp;a new frontier or a repeat of past mistakes?

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Weight loss medications in Canada – a new frontier or a repeat of past mistakes?