Incidence of schizophrenia and other psychoses in England, 1950-2009: a systematic review and meta-analyses.

<h4>Background</h4>We conducted a systematic review of incidence rates in England over a sixty-year period to determine the extent to which rates varied along accepted (age, sex) and less-accepted epidemiological gradients (ethnicity, migration and place of birth and upbringing, time).&l...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	James B Kirkbride, Antonia Errazuriz, Tim J Croudace, Craig Morgan, Daniel Jackson, Jane Boydell, Robin M Murray, Peter B Jones
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2ebdae7a7e234bd28dff56ca555c10dd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2ebdae7a7e234bd28dff56ca555c10dd
record_format	dspace
spelling	oai:doaj.org-article:2ebdae7a7e234bd28dff56ca555c10dd2021-11-18T07:24:31ZIncidence of schizophrenia and other psychoses in England, 1950-2009: a systematic review and meta-analyses.1932-620310.1371/journal.pone.0031660https://doaj.org/article/2ebdae7a7e234bd28dff56ca555c10dd2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22457710/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>We conducted a systematic review of incidence rates in England over a sixty-year period to determine the extent to which rates varied along accepted (age, sex) and less-accepted epidemiological gradients (ethnicity, migration and place of birth and upbringing, time).<h4>Objectives</h4>To determine variation in incidence of several psychotic disorders as above.<h4>Data sources</h4>Published and grey literature searches (MEDLINE, PSycINFO, EMBASE, CINAHL, ASSIA, HMIC), and identification of unpublished data through bibliographic searches and author communication.<h4>Study eligibility criteria</h4>Published 1950-2009; conducted wholly or partially in England; original data on incidence of non-organic adult-onset psychosis or one or more factor(s) pertaining to incidence.<h4>Participants</h4>People, 16-64 years, with first -onset psychosis, including non-affective psychoses, schizophrenia, bipolar disorder, psychotic depression and substance-induced psychosis.<h4>Study appraisal and synthesis methods</h4>Title, abstract and full-text review by two independent raters to identify suitable citations. Data were extracted to a standardized extraction form. Descriptive appraisals of variation in rates, including tables and forest plots, and where suitable, random-effects meta-analyses and meta-regressions to test specific hypotheses; rate heterogeneity was assessed by the I²-statistic.<h4>Results</h4>83 citations met inclusion. Pooled incidence of all psychoses (N = 9) was 31.7 per 100,000 person-years (95%CI: 24.6-40.9), 23.2 (95%CI: 18.3-29.5) for non-affective psychoses (N = 8), 15.2 (95%CI: 11.9-19.5) for schizophrenia (N = 15) and 12.4 (95%CI: 9.0-17.1) for affective psychoses (N = 7). This masked rate heterogeneity (I²: 0.54-0.97), possibly explained by socio-environmental factors; our review confirmed (via meta-regression) the typical age-sex interaction in psychosis risk, including secondary peak onset in women after 45 years. Rates of most disorders were elevated in several ethnic minority groups compared with the white (British) population. For example, for schizophrenia: black Caribbean (pooled RR: 5.6; 95%CI: 3.4-9.2; N = 5), black African (pooled RR: 4.7; 95%CI: 3.3-6.8; N = 5) and South Asian groups in England (pooled RR: 2.4; 95%CI: 1.3-4.5; N = 3). We found no evidence to support an overall change in the incidence of psychotic disorder over time, though diagnostic shifts (away from schizophrenia) were reported.<h4>Limitations</h4>Incidence studies were predominantly cross-sectional, limiting causal inference. Heterogeneity, while evidencing important variation, suggested pooled estimates require interpretation alongside our descriptive systematic results.<h4>Conclusions and implications of key findings</h4>Incidence of psychotic disorders varied markedly by age, sex, place and migration status/ethnicity. Stable incidence over time, together with a robust socio-environmental epidemiology, provides a platform for developing prediction models for health service planning.James B KirkbrideAntonia ErrazurizTim J CroudaceCraig MorganDaniel JacksonJane BoydellRobin M MurrayPeter B JonesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e31660 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q James B Kirkbride Antonia Errazuriz Tim J Croudace Craig Morgan Daniel Jackson Jane Boydell Robin M Murray Peter B Jones Incidence of schizophrenia and other psychoses in England, 1950-2009: a systematic review and meta-analyses.
description	<h4>Background</h4>We conducted a systematic review of incidence rates in England over a sixty-year period to determine the extent to which rates varied along accepted (age, sex) and less-accepted epidemiological gradients (ethnicity, migration and place of birth and upbringing, time).<h4>Objectives</h4>To determine variation in incidence of several psychotic disorders as above.<h4>Data sources</h4>Published and grey literature searches (MEDLINE, PSycINFO, EMBASE, CINAHL, ASSIA, HMIC), and identification of unpublished data through bibliographic searches and author communication.<h4>Study eligibility criteria</h4>Published 1950-2009; conducted wholly or partially in England; original data on incidence of non-organic adult-onset psychosis or one or more factor(s) pertaining to incidence.<h4>Participants</h4>People, 16-64 years, with first -onset psychosis, including non-affective psychoses, schizophrenia, bipolar disorder, psychotic depression and substance-induced psychosis.<h4>Study appraisal and synthesis methods</h4>Title, abstract and full-text review by two independent raters to identify suitable citations. Data were extracted to a standardized extraction form. Descriptive appraisals of variation in rates, including tables and forest plots, and where suitable, random-effects meta-analyses and meta-regressions to test specific hypotheses; rate heterogeneity was assessed by the I²-statistic.<h4>Results</h4>83 citations met inclusion. Pooled incidence of all psychoses (N = 9) was 31.7 per 100,000 person-years (95%CI: 24.6-40.9), 23.2 (95%CI: 18.3-29.5) for non-affective psychoses (N = 8), 15.2 (95%CI: 11.9-19.5) for schizophrenia (N = 15) and 12.4 (95%CI: 9.0-17.1) for affective psychoses (N = 7). This masked rate heterogeneity (I²: 0.54-0.97), possibly explained by socio-environmental factors; our review confirmed (via meta-regression) the typical age-sex interaction in psychosis risk, including secondary peak onset in women after 45 years. Rates of most disorders were elevated in several ethnic minority groups compared with the white (British) population. For example, for schizophrenia: black Caribbean (pooled RR: 5.6; 95%CI: 3.4-9.2; N = 5), black African (pooled RR: 4.7; 95%CI: 3.3-6.8; N = 5) and South Asian groups in England (pooled RR: 2.4; 95%CI: 1.3-4.5; N = 3). We found no evidence to support an overall change in the incidence of psychotic disorder over time, though diagnostic shifts (away from schizophrenia) were reported.<h4>Limitations</h4>Incidence studies were predominantly cross-sectional, limiting causal inference. Heterogeneity, while evidencing important variation, suggested pooled estimates require interpretation alongside our descriptive systematic results.<h4>Conclusions and implications of key findings</h4>Incidence of psychotic disorders varied markedly by age, sex, place and migration status/ethnicity. Stable incidence over time, together with a robust socio-environmental epidemiology, provides a platform for developing prediction models for health service planning.
format	article
author	James B Kirkbride Antonia Errazuriz Tim J Croudace Craig Morgan Daniel Jackson Jane Boydell Robin M Murray Peter B Jones
author_facet	James B Kirkbride Antonia Errazuriz Tim J Croudace Craig Morgan Daniel Jackson Jane Boydell Robin M Murray Peter B Jones
author_sort	James B Kirkbride
title	Incidence of schizophrenia and other psychoses in England, 1950-2009: a systematic review and meta-analyses.
title_short	Incidence of schizophrenia and other psychoses in England, 1950-2009: a systematic review and meta-analyses.
title_full	Incidence of schizophrenia and other psychoses in England, 1950-2009: a systematic review and meta-analyses.
title_fullStr	Incidence of schizophrenia and other psychoses in England, 1950-2009: a systematic review and meta-analyses.
title_full_unstemmed	Incidence of schizophrenia and other psychoses in England, 1950-2009: a systematic review and meta-analyses.
title_sort	incidence of schizophrenia and other psychoses in england, 1950-2009: a systematic review and meta-analyses.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/2ebdae7a7e234bd28dff56ca555c10dd
work_keys_str_mv	AT jamesbkirkbride incidenceofschizophreniaandotherpsychosesinengland19502009asystematicreviewandmetaanalyses AT antoniaerrazuriz incidenceofschizophreniaandotherpsychosesinengland19502009asystematicreviewandmetaanalyses AT timjcroudace incidenceofschizophreniaandotherpsychosesinengland19502009asystematicreviewandmetaanalyses AT craigmorgan incidenceofschizophreniaandotherpsychosesinengland19502009asystematicreviewandmetaanalyses AT danieljackson incidenceofschizophreniaandotherpsychosesinengland19502009asystematicreviewandmetaanalyses AT janeboydell incidenceofschizophreniaandotherpsychosesinengland19502009asystematicreviewandmetaanalyses AT robinmmurray incidenceofschizophreniaandotherpsychosesinengland19502009asystematicreviewandmetaanalyses AT peterbjones incidenceofschizophreniaandotherpsychosesinengland19502009asystematicreviewandmetaanalyses
_version_	1718423465031106560

Incidence of schizophrenia and other psychoses in England, 1950-2009: a systematic review and meta-analyses.

Ejemplares similares