Drug self-assembly for synthesis of highly-loaded antimicrobial drug-silica particles

Abstract Antimicrobial drug release from biomaterials for orthopedic repair and dental restorations can prevent biofilm growth and caries formation. Carriers for drug incorporation would benefit from long-term drug storage, controlled release, and structural stability. Mesoporous silica, synthesized...

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Autores principales:	Cameron A. Stewart, Yoav Finer, Benjamin D. Hatton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2ebefac9bc1a415ea6d6bfb0390d5c85
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spelling	oai:doaj.org-article:2ebefac9bc1a415ea6d6bfb0390d5c852021-12-02T15:08:45ZDrug self-assembly for synthesis of highly-loaded antimicrobial drug-silica particles10.1038/s41598-018-19166-82045-2322https://doaj.org/article/2ebefac9bc1a415ea6d6bfb0390d5c852018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19166-8https://doaj.org/toc/2045-2322Abstract Antimicrobial drug release from biomaterials for orthopedic repair and dental restorations can prevent biofilm growth and caries formation. Carriers for drug incorporation would benefit from long-term drug storage, controlled release, and structural stability. Mesoporous silica, synthesized through a co-assembly of silica and surfactant template, is an ideal drug encapsulation scaffold that maintains structural integrity upon release. However, conventional loading of drug within meso-silica pores via concentration-gradient diffusion limits the overall payload, concentration uniformity, and drug release control. Herein we demonstrate the co-assembly of an antimicrobial drug (octenidine dihydrochloride, OCT), and silica, to form highly-loaded (35% wt.) OCT-silica nanocomposite spheres of 500 nm diameter. Drug release significantly outlasted conventional OCT-loaded mesoporous silica, closely fit Higuchi models of diffusive release, and was visualized via electron microscopy. Extension of this concept to the broad collection of self-assembling drugs grants biomedical community a powerful tool for synthesizing drug-loaded inorganic nanomaterials from the bottom-up.Cameron A. StewartYoav FinerBenjamin D. HattonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cameron A. Stewart Yoav Finer Benjamin D. Hatton Drug self-assembly for synthesis of highly-loaded antimicrobial drug-silica particles
description	Abstract Antimicrobial drug release from biomaterials for orthopedic repair and dental restorations can prevent biofilm growth and caries formation. Carriers for drug incorporation would benefit from long-term drug storage, controlled release, and structural stability. Mesoporous silica, synthesized through a co-assembly of silica and surfactant template, is an ideal drug encapsulation scaffold that maintains structural integrity upon release. However, conventional loading of drug within meso-silica pores via concentration-gradient diffusion limits the overall payload, concentration uniformity, and drug release control. Herein we demonstrate the co-assembly of an antimicrobial drug (octenidine dihydrochloride, OCT), and silica, to form highly-loaded (35% wt.) OCT-silica nanocomposite spheres of 500 nm diameter. Drug release significantly outlasted conventional OCT-loaded mesoporous silica, closely fit Higuchi models of diffusive release, and was visualized via electron microscopy. Extension of this concept to the broad collection of self-assembling drugs grants biomedical community a powerful tool for synthesizing drug-loaded inorganic nanomaterials from the bottom-up.
format	article
author	Cameron A. Stewart Yoav Finer Benjamin D. Hatton
author_facet	Cameron A. Stewart Yoav Finer Benjamin D. Hatton
author_sort	Cameron A. Stewart
title	Drug self-assembly for synthesis of highly-loaded antimicrobial drug-silica particles
title_short	Drug self-assembly for synthesis of highly-loaded antimicrobial drug-silica particles
title_full	Drug self-assembly for synthesis of highly-loaded antimicrobial drug-silica particles
title_fullStr	Drug self-assembly for synthesis of highly-loaded antimicrobial drug-silica particles
title_full_unstemmed	Drug self-assembly for synthesis of highly-loaded antimicrobial drug-silica particles
title_sort	drug self-assembly for synthesis of highly-loaded antimicrobial drug-silica particles
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2ebefac9bc1a415ea6d6bfb0390d5c85
work_keys_str_mv	AT cameronastewart drugselfassemblyforsynthesisofhighlyloadedantimicrobialdrugsilicaparticles AT yoavfiner drugselfassemblyforsynthesisofhighlyloadedantimicrobialdrugsilicaparticles AT benjamindhatton drugselfassemblyforsynthesisofhighlyloadedantimicrobialdrugsilicaparticles
_version_	1718387989684420608

Drug self-assembly for synthesis of highly-loaded antimicrobial drug-silica particles

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