Clinicopathological features and prognosis of gastric adenosquamous carcinoma

Abstract Data about primary gastric adenosquamous carcinoma (ASC) was limited due to rare incidence. Thus, the present study aims to investigate clinicopathological features and prognosis of gastric ASC. Cases of gastric ASC were obtained from our center and from case reports and series extracted fr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fan Feng, Gaozan Zheng, Jingpeng Qi, Guanghui Xu, Fei Wang, Qiao Wang, Man Guo, Xiao Lian, Hongwei Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2ebf3c5d7c934c3890511763a03cc8c1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2ebf3c5d7c934c3890511763a03cc8c1
record_format	dspace
spelling	oai:doaj.org-article:2ebf3c5d7c934c3890511763a03cc8c12021-12-02T12:30:44ZClinicopathological features and prognosis of gastric adenosquamous carcinoma10.1038/s41598-017-04563-22045-2322https://doaj.org/article/2ebf3c5d7c934c3890511763a03cc8c12017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04563-2https://doaj.org/toc/2045-2322Abstract Data about primary gastric adenosquamous carcinoma (ASC) was limited due to rare incidence. Thus, the present study aims to investigate clinicopathological features and prognosis of gastric ASC. Cases of gastric ASC were obtained from our center and from case reports and series extracted from Medline. Clinicopathological features and prognosis of gastric ASC were analyzed and compared with gastric adenocarcinoma (AC) in our center. The commonest location was lower third (45.0%), followed by upper (26.2%) and middle third (24.2%). The median tumor size was 6 cm (0.8–17). The commonest differentiation status was well for both AC (44.4%) and SCC components (40.9%). Half of tumors (52.7%) were stage T4 and most patients (86.2%) suffered from lymph node metastasis (LNM). Tumor depth and TNM stage were risk factors for overall survival (OS) (both P < 0.05). The distribution of age, tumor size, tumor location, tumor depth, LNM and TNM stage were significantly different between gastric ASC and AC (all P < 0.05). The OS of gastric ASC was significantly worse than AC (P < 0.001), especially in stage III disease (P < 0.001). Gastric ASC differ significantly from AC with respect to clinicopathological features. The prognosis of gastric ASC was worse than AC.Fan FengGaozan ZhengJingpeng QiGuanghui XuFei WangQiao WangMan GuoXiao LianHongwei ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fan Feng Gaozan Zheng Jingpeng Qi Guanghui Xu Fei Wang Qiao Wang Man Guo Xiao Lian Hongwei Zhang Clinicopathological features and prognosis of gastric adenosquamous carcinoma
description	Abstract Data about primary gastric adenosquamous carcinoma (ASC) was limited due to rare incidence. Thus, the present study aims to investigate clinicopathological features and prognosis of gastric ASC. Cases of gastric ASC were obtained from our center and from case reports and series extracted from Medline. Clinicopathological features and prognosis of gastric ASC were analyzed and compared with gastric adenocarcinoma (AC) in our center. The commonest location was lower third (45.0%), followed by upper (26.2%) and middle third (24.2%). The median tumor size was 6 cm (0.8–17). The commonest differentiation status was well for both AC (44.4%) and SCC components (40.9%). Half of tumors (52.7%) were stage T4 and most patients (86.2%) suffered from lymph node metastasis (LNM). Tumor depth and TNM stage were risk factors for overall survival (OS) (both P < 0.05). The distribution of age, tumor size, tumor location, tumor depth, LNM and TNM stage were significantly different between gastric ASC and AC (all P < 0.05). The OS of gastric ASC was significantly worse than AC (P < 0.001), especially in stage III disease (P < 0.001). Gastric ASC differ significantly from AC with respect to clinicopathological features. The prognosis of gastric ASC was worse than AC.
format	article
author	Fan Feng Gaozan Zheng Jingpeng Qi Guanghui Xu Fei Wang Qiao Wang Man Guo Xiao Lian Hongwei Zhang
author_facet	Fan Feng Gaozan Zheng Jingpeng Qi Guanghui Xu Fei Wang Qiao Wang Man Guo Xiao Lian Hongwei Zhang
author_sort	Fan Feng
title	Clinicopathological features and prognosis of gastric adenosquamous carcinoma
title_short	Clinicopathological features and prognosis of gastric adenosquamous carcinoma
title_full	Clinicopathological features and prognosis of gastric adenosquamous carcinoma
title_fullStr	Clinicopathological features and prognosis of gastric adenosquamous carcinoma
title_full_unstemmed	Clinicopathological features and prognosis of gastric adenosquamous carcinoma
title_sort	clinicopathological features and prognosis of gastric adenosquamous carcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2ebf3c5d7c934c3890511763a03cc8c1
work_keys_str_mv	AT fanfeng clinicopathologicalfeaturesandprognosisofgastricadenosquamouscarcinoma AT gaozanzheng clinicopathologicalfeaturesandprognosisofgastricadenosquamouscarcinoma AT jingpengqi clinicopathologicalfeaturesandprognosisofgastricadenosquamouscarcinoma AT guanghuixu clinicopathologicalfeaturesandprognosisofgastricadenosquamouscarcinoma AT feiwang clinicopathologicalfeaturesandprognosisofgastricadenosquamouscarcinoma AT qiaowang clinicopathologicalfeaturesandprognosisofgastricadenosquamouscarcinoma AT manguo clinicopathologicalfeaturesandprognosisofgastricadenosquamouscarcinoma AT xiaolian clinicopathologicalfeaturesandprognosisofgastricadenosquamouscarcinoma AT hongweizhang clinicopathologicalfeaturesandprognosisofgastricadenosquamouscarcinoma
_version_	1718394325434368000

Clinicopathological features and prognosis of gastric adenosquamous carcinoma

Ejemplares similares