Improved GPCR ligands from nanobody tethering

Antibodies conjugated to bioactive compounds can allow targeted delivery of therapeutics. Here the authors present a strategy for fusing nanobodies to suboptimal GPCR peptide ligands to potently and selectively activate receptors.

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Autores principales:	Ross W. Cheloha, Fabian A. Fischer, Andrew W. Woodham, Eileen Daley, Naomi Suminski, Thomas J. Gardella, Hidde L. Ploegh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2ec526511b22420986044ab4ea9c3e47
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spelling	oai:doaj.org-article:2ec526511b22420986044ab4ea9c3e472021-12-02T14:40:53ZImproved GPCR ligands from nanobody tethering10.1038/s41467-020-15884-82041-1723https://doaj.org/article/2ec526511b22420986044ab4ea9c3e472020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15884-8https://doaj.org/toc/2041-1723Antibodies conjugated to bioactive compounds can allow targeted delivery of therapeutics. Here the authors present a strategy for fusing nanobodies to suboptimal GPCR peptide ligands to potently and selectively activate receptors.Ross W. ChelohaFabian A. FischerAndrew W. WoodhamEileen DaleyNaomi SuminskiThomas J. GardellaHidde L. PloeghNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ross W. Cheloha Fabian A. Fischer Andrew W. Woodham Eileen Daley Naomi Suminski Thomas J. Gardella Hidde L. Ploegh Improved GPCR ligands from nanobody tethering
description	Antibodies conjugated to bioactive compounds can allow targeted delivery of therapeutics. Here the authors present a strategy for fusing nanobodies to suboptimal GPCR peptide ligands to potently and selectively activate receptors.
format	article
author	Ross W. Cheloha Fabian A. Fischer Andrew W. Woodham Eileen Daley Naomi Suminski Thomas J. Gardella Hidde L. Ploegh
author_facet	Ross W. Cheloha Fabian A. Fischer Andrew W. Woodham Eileen Daley Naomi Suminski Thomas J. Gardella Hidde L. Ploegh
author_sort	Ross W. Cheloha
title	Improved GPCR ligands from nanobody tethering
title_short	Improved GPCR ligands from nanobody tethering
title_full	Improved GPCR ligands from nanobody tethering
title_fullStr	Improved GPCR ligands from nanobody tethering
title_full_unstemmed	Improved GPCR ligands from nanobody tethering
title_sort	improved gpcr ligands from nanobody tethering
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2ec526511b22420986044ab4ea9c3e47
work_keys_str_mv	AT rosswcheloha improvedgpcrligandsfromnanobodytethering AT fabianafischer improvedgpcrligandsfromnanobodytethering AT andrewwwoodham improvedgpcrligandsfromnanobodytethering AT eileendaley improvedgpcrligandsfromnanobodytethering AT naomisuminski improvedgpcrligandsfromnanobodytethering AT thomasjgardella improvedgpcrligandsfromnanobodytethering AT hiddelploegh improvedgpcrligandsfromnanobodytethering
_version_	1718390102019801088

Improved GPCR ligands from nanobody tethering

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