Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles
Neovascular age-related macular degeneration and diabetic retinopathy are currently treated with repeated intravitreous injections of VEGF neutralizing proteins. Here the authors develop a microparticle-loaded tyrosine kinase inhibitor therapy, which is effective for six months after a single inject...
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Nature Portfolio
2020
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oai:doaj.org-article:2ec68ea8afa548e39d54ab7c4b1ff7de2021-12-02T14:41:13ZSustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles10.1038/s41467-020-14340-x2041-1723https://doaj.org/article/2ec68ea8afa548e39d54ab7c4b1ff7de2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14340-xhttps://doaj.org/toc/2041-1723Neovascular age-related macular degeneration and diabetic retinopathy are currently treated with repeated intravitreous injections of VEGF neutralizing proteins. Here the authors develop a microparticle-loaded tyrosine kinase inhibitor therapy, which is effective for six months after a single injection in preclinical models.Hiroki TsujinakaJie FuJikui ShenYun YuZibran HafizJoshua KaysDavid McKenzieDelia CardonaDavid CulpWard PetersonBrian C. GilgerChristopher S. CreanJin-Zhong ZhangYogita KananWeiling YuJeffrey L. ClelandMing YangJustin HanesPeter A. CampochiaroNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Hiroki Tsujinaka Jie Fu Jikui Shen Yun Yu Zibran Hafiz Joshua Kays David McKenzie Delia Cardona David Culp Ward Peterson Brian C. Gilger Christopher S. Crean Jin-Zhong Zhang Yogita Kanan Weiling Yu Jeffrey L. Cleland Ming Yang Justin Hanes Peter A. Campochiaro Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles |
| description |
Neovascular age-related macular degeneration and diabetic retinopathy are currently treated with repeated intravitreous injections of VEGF neutralizing proteins. Here the authors develop a microparticle-loaded tyrosine kinase inhibitor therapy, which is effective for six months after a single injection in preclinical models. |
| format |
article |
| author |
Hiroki Tsujinaka Jie Fu Jikui Shen Yun Yu Zibran Hafiz Joshua Kays David McKenzie Delia Cardona David Culp Ward Peterson Brian C. Gilger Christopher S. Crean Jin-Zhong Zhang Yogita Kanan Weiling Yu Jeffrey L. Cleland Ming Yang Justin Hanes Peter A. Campochiaro |
| author_facet |
Hiroki Tsujinaka Jie Fu Jikui Shen Yun Yu Zibran Hafiz Joshua Kays David McKenzie Delia Cardona David Culp Ward Peterson Brian C. Gilger Christopher S. Crean Jin-Zhong Zhang Yogita Kanan Weiling Yu Jeffrey L. Cleland Ming Yang Justin Hanes Peter A. Campochiaro |
| author_sort |
Hiroki Tsujinaka |
| title |
Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles |
| title_short |
Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles |
| title_full |
Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles |
| title_fullStr |
Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles |
| title_full_unstemmed |
Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles |
| title_sort |
sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/2ec68ea8afa548e39d54ab7c4b1ff7de |
| work_keys_str_mv |
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| _version_ |
1718389981957849088 |