Gene of folate cycle MTHFR and nutrition

Climatic and geographical features always influenced on adaptation to the environment as well as the development level of economy and culture. The formation of certain food behavior in population determined fixation of specific gene alleles and mutation. They were responsible for digestion a typical...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	K. D. Ievleva, T. A. Bairova, O. V. Kalyuzhnaya, O. A. Pervushina, L. V. Rychkova, L. I. Kolesnikova, S. I. Kolesnikov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	mthfr 677c>t russian buryat genotyping frequency Science Q
Acceso en línea:	https://doaj.org/article/2ec70cf0f5c442e89594f10cb310708c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2ec70cf0f5c442e89594f10cb310708c
record_format	dspace
spelling	oai:doaj.org-article:2ec70cf0f5c442e89594f10cb310708c2021-11-23T06:14:34ZGene of folate cycle MTHFR and nutrition2541-94202587-959610.12737/article_590823a5316dd5.54345742https://doaj.org/article/2ec70cf0f5c442e89594f10cb310708c2016-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/207https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Climatic and geographical features always influenced on adaptation to the environment as well as the development level of economy and culture. The formation of certain food behavior in population determined fixation of specific gene alleles and mutation. They were responsible for digestion a typical food for the population. At the moment there is information about such genetic features as metabolism of proteins, carbohydrates and fats for many races and nations. But a few studies are about causes of prevalence differences of gene polymorphisms of folate cycle in the world's populations. The main objective was to explore 677C>T mutation MTHFR gene among Russian and Buryat to compare it with ones in other populations. The total of399 children and adolescents (200 Russians and 199 Buryats) were involved in this study. Genotyping of MTHFR 677C>T was performed by PCR-RT We used soft "STATISTICA 8.0" to compare results. As a result, T-allele frequency was 30 % in Russians and 21,1 % in Buryats. We found significant differences of prevalence of polymorphism 677C>T between studied groups (p = 0.011). Also we found significant difference between Russian and British (p = 0.054), French (p = 0.0263), Spanish (p < 0.0001), Italian (p < 0.0001) and Greek samples (p = 0.0454). The Buryat group had significant differences with Chinese (p < 0.0001), Korean (p < 0.0001), Mongolian (p < 0.004), Japanese (p < 0.0001), Kazakh (p = 0.0198) samples and two samples of Hans (p < 0.0001; p = 0.0390).K. D. IevlevaT. A. BairovaO. V. KalyuzhnayaO. A. PervushinaL. V. RychkovaL. I. KolesnikovaS. I. KolesnikovScientific Сentre for Family Health and Human Reproduction Problemsarticlemthfr 677c>trussianburyatgenotypingmthfr 677c>tfrequencyScienceQRUActa Biomedica Scientifica, Vol 1, Iss 3(2), Pp 138-144 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	mthfr 677c>t russian buryat genotyping mthfr 677c>t frequency Science Q
spellingShingle	mthfr 677c>t russian buryat genotyping mthfr 677c>t frequency Science Q K. D. Ievleva T. A. Bairova O. V. Kalyuzhnaya O. A. Pervushina L. V. Rychkova L. I. Kolesnikova S. I. Kolesnikov Gene of folate cycle MTHFR and nutrition
description	Climatic and geographical features always influenced on adaptation to the environment as well as the development level of economy and culture. The formation of certain food behavior in population determined fixation of specific gene alleles and mutation. They were responsible for digestion a typical food for the population. At the moment there is information about such genetic features as metabolism of proteins, carbohydrates and fats for many races and nations. But a few studies are about causes of prevalence differences of gene polymorphisms of folate cycle in the world's populations. The main objective was to explore 677C>T mutation MTHFR gene among Russian and Buryat to compare it with ones in other populations. The total of399 children and adolescents (200 Russians and 199 Buryats) were involved in this study. Genotyping of MTHFR 677C>T was performed by PCR-RT We used soft "STATISTICA 8.0" to compare results. As a result, T-allele frequency was 30 % in Russians and 21,1 % in Buryats. We found significant differences of prevalence of polymorphism 677C>T between studied groups (p = 0.011). Also we found significant difference between Russian and British (p = 0.054), French (p = 0.0263), Spanish (p < 0.0001), Italian (p < 0.0001) and Greek samples (p = 0.0454). The Buryat group had significant differences with Chinese (p < 0.0001), Korean (p < 0.0001), Mongolian (p < 0.004), Japanese (p < 0.0001), Kazakh (p = 0.0198) samples and two samples of Hans (p < 0.0001; p = 0.0390).
format	article
author	K. D. Ievleva T. A. Bairova O. V. Kalyuzhnaya O. A. Pervushina L. V. Rychkova L. I. Kolesnikova S. I. Kolesnikov
author_facet	K. D. Ievleva T. A. Bairova O. V. Kalyuzhnaya O. A. Pervushina L. V. Rychkova L. I. Kolesnikova S. I. Kolesnikov
author_sort	K. D. Ievleva
title	Gene of folate cycle MTHFR and nutrition
title_short	Gene of folate cycle MTHFR and nutrition
title_full	Gene of folate cycle MTHFR and nutrition
title_fullStr	Gene of folate cycle MTHFR and nutrition
title_full_unstemmed	Gene of folate cycle MTHFR and nutrition
title_sort	gene of folate cycle mthfr and nutrition
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/2ec70cf0f5c442e89594f10cb310708c
work_keys_str_mv	AT kdievleva geneoffolatecyclemthfrandnutrition AT tabairova geneoffolatecyclemthfrandnutrition AT ovkalyuzhnaya geneoffolatecyclemthfrandnutrition AT oapervushina geneoffolatecyclemthfrandnutrition AT lvrychkova geneoffolatecyclemthfrandnutrition AT likolesnikova geneoffolatecyclemthfrandnutrition AT sikolesnikov geneoffolatecyclemthfrandnutrition
_version_	1718417060444241920

Gene of folate cycle MTHFR and nutrition

Ejemplares similares