Optogenetic stimulation of the VTA modulates a frequency-specific gain of thalamocortical inputs in infragranular layers of the auditory cortex

Abstract Reward associations during auditory learning induce cortical plasticity in the primary auditory cortex. A prominent source of such influence is the ventral tegmental area (VTA), which conveys a dopaminergic teaching signal to the primary auditory cortex. Yet, it is unknown, how the VTA infl...

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Auteurs principaux:	Michael G. K. Brunk, Katrina E. Deane, Martin Kisse, Matthias Deliano, Silvia Vieweg, Frank W. Ohl, Michael T. Lippert, Max F. K. Happel
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/2ed2eb32b1524790967f39e9fa60417a
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spelling	oai:doaj.org-article:2ed2eb32b1524790967f39e9fa60417a2021-12-02T15:12:47ZOptogenetic stimulation of the VTA modulates a frequency-specific gain of thalamocortical inputs in infragranular layers of the auditory cortex10.1038/s41598-019-56926-62045-2322https://doaj.org/article/2ed2eb32b1524790967f39e9fa60417a2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-56926-6https://doaj.org/toc/2045-2322Abstract Reward associations during auditory learning induce cortical plasticity in the primary auditory cortex. A prominent source of such influence is the ventral tegmental area (VTA), which conveys a dopaminergic teaching signal to the primary auditory cortex. Yet, it is unknown, how the VTA influences cortical frequency processing and spectral integration. Therefore, we investigated the temporal effects of direct optogenetic stimulation of the VTA onto spectral integration in the auditory cortex on a synaptic circuit level by current-source-density analysis in anesthetized Mongolian gerbils. While auditory lemniscal input predominantly terminates in the granular input layers III/IV, we found that VTA-mediated modulation of spectral processing is relayed by a different circuit, namely enhanced thalamic inputs to the infragranular layers Vb/VIa. Activation of this circuit yields a frequency-specific gain amplification of local sensory input and enhances corticocortical information transfer, especially in supragranular layers I/II. This effects persisted over more than 30 minutes after VTA stimulation. Altogether, we demonstrate that the VTA exhibits a long-lasting influence on sensory cortical processing via infragranular layers transcending the signaling of a mere reward-prediction error. We thereby demonstrate a cellular and circuit substrate for the influence of reinforcement-evaluating brain systems on sensory processing in the auditory cortex.Michael G. K. BrunkKatrina E. DeaneMartin KisseMatthias DelianoSilvia ViewegFrank W. OhlMichael T. LippertMax F. K. HappelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael G. K. Brunk Katrina E. Deane Martin Kisse Matthias Deliano Silvia Vieweg Frank W. Ohl Michael T. Lippert Max F. K. Happel Optogenetic stimulation of the VTA modulates a frequency-specific gain of thalamocortical inputs in infragranular layers of the auditory cortex
description	Abstract Reward associations during auditory learning induce cortical plasticity in the primary auditory cortex. A prominent source of such influence is the ventral tegmental area (VTA), which conveys a dopaminergic teaching signal to the primary auditory cortex. Yet, it is unknown, how the VTA influences cortical frequency processing and spectral integration. Therefore, we investigated the temporal effects of direct optogenetic stimulation of the VTA onto spectral integration in the auditory cortex on a synaptic circuit level by current-source-density analysis in anesthetized Mongolian gerbils. While auditory lemniscal input predominantly terminates in the granular input layers III/IV, we found that VTA-mediated modulation of spectral processing is relayed by a different circuit, namely enhanced thalamic inputs to the infragranular layers Vb/VIa. Activation of this circuit yields a frequency-specific gain amplification of local sensory input and enhances corticocortical information transfer, especially in supragranular layers I/II. This effects persisted over more than 30 minutes after VTA stimulation. Altogether, we demonstrate that the VTA exhibits a long-lasting influence on sensory cortical processing via infragranular layers transcending the signaling of a mere reward-prediction error. We thereby demonstrate a cellular and circuit substrate for the influence of reinforcement-evaluating brain systems on sensory processing in the auditory cortex.
format	article
author	Michael G. K. Brunk Katrina E. Deane Martin Kisse Matthias Deliano Silvia Vieweg Frank W. Ohl Michael T. Lippert Max F. K. Happel
author_facet	Michael G. K. Brunk Katrina E. Deane Martin Kisse Matthias Deliano Silvia Vieweg Frank W. Ohl Michael T. Lippert Max F. K. Happel
author_sort	Michael G. K. Brunk
title	Optogenetic stimulation of the VTA modulates a frequency-specific gain of thalamocortical inputs in infragranular layers of the auditory cortex
title_short	Optogenetic stimulation of the VTA modulates a frequency-specific gain of thalamocortical inputs in infragranular layers of the auditory cortex
title_full	Optogenetic stimulation of the VTA modulates a frequency-specific gain of thalamocortical inputs in infragranular layers of the auditory cortex
title_fullStr	Optogenetic stimulation of the VTA modulates a frequency-specific gain of thalamocortical inputs in infragranular layers of the auditory cortex
title_full_unstemmed	Optogenetic stimulation of the VTA modulates a frequency-specific gain of thalamocortical inputs in infragranular layers of the auditory cortex
title_sort	optogenetic stimulation of the vta modulates a frequency-specific gain of thalamocortical inputs in infragranular layers of the auditory cortex
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2ed2eb32b1524790967f39e9fa60417a
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Optogenetic stimulation of the VTA modulates a frequency-specific gain of thalamocortical inputs in infragranular layers of the auditory cortex

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