Metastasis rates and sites after treatment for choroidal melanoma by proton beam irradiation or by enucleation

Chryssanthi Koutsandrea, Marilita M Moschos, Michael Dimissianos, Gerasimos Georgopoulos, Ioannnis Ladas, Michael ApostolopoulosDepartment of Ophthalmology, Athens University, Athens, GreecePurpose: To investigate tumor thickness and location, the interval of time between treatment for choroidal mel...

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Autores principales:	Chryssanthi Koutsandrea, Marilita M Moschos, Michael Dimissianos, Gerasimos Georgopoulos, Ioannnis Ladas, Michael Apostolopoulos
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/2ed339b1741d4d18abd5c464918a4b31
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spelling	oai:doaj.org-article:2ed339b1741d4d18abd5c464918a4b312021-12-02T08:25:39ZMetastasis rates and sites after treatment for choroidal melanoma by proton beam irradiation or by enucleation1177-54671177-5483https://doaj.org/article/2ed339b1741d4d18abd5c464918a4b312008-08-01T00:00:00Zhttp://www.dovepress.com/metastasis-rates-and-sites-after-treatment-for-choroidal-melanoma-by-p-a2024https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Chryssanthi Koutsandrea, Marilita M Moschos, Michael Dimissianos, Gerasimos Georgopoulos, Ioannnis Ladas, Michael ApostolopoulosDepartment of Ophthalmology, Athens University, Athens, GreecePurpose: To investigate tumor thickness and location, the interval of time between treatment for choroidal melanoma (proton beam irradiation or enucleation) and diagnosis of metastatic disease, and rates and sites of metastasis.Design: Retrospective, interventional, noncomparative case series.Methods: Follow-up of 152 patients with primary choroidal melanoma, between 1992 and 2006 (14 years). One hundred and twenty-one patients were treated with proton beam irradiation and 31 patients were treated with enucleation. Baseline and annual or semiannual ophthalmic examination, B-scan ultrasonography, systemic and laboratory evaluations (liver enzymes, chest X-ray, ultrasonography or magnetic resonance imaging of the liver) were performed according to a standard protocol.Results: Nineteen patients (12.5%) were diagnosed with metastasis during follow-up time after treatment for choroidal melanoma. Thirteen patients (10.7%) of the irradiation group and 6 patients (19.3%) of the enucleation group were diagnosed with metastasis. Eight patients (6.6%) of the irradiation group and 5 patients (16.1%) of the enucleation group were diagnosed with liver metastasis. Ocular complications after proton beam irradiation were recorded. Fifty-nine patients (48.7%) of the irradiation group presented with cataract. Other complications were retinal detachment, retinopathy, vitreous haemorrhage, iris neovascularization, neovascular glaucoma, optic neuropathy, and corneal opacification.Conclusions: In our series, 10.7% of the irradiation group and 19.3% of the enucleation group were diagnosed with metastasis. The liver was the most common site of metastasis in both groups. Cataract was the most common complication in the irradiation group.Keywords: melanoma, metastasis, irradiation, enucleation Chryssanthi KoutsandreaMarilita M MoschosMichael DimissianosGerasimos GeorgopoulosIoannnis LadasMichael ApostolopoulosDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2008, Iss Issue 4, Pp 989-995 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Chryssanthi Koutsandrea Marilita M Moschos Michael Dimissianos Gerasimos Georgopoulos Ioannnis Ladas Michael Apostolopoulos Metastasis rates and sites after treatment for choroidal melanoma by proton beam irradiation or by enucleation
description	Chryssanthi Koutsandrea, Marilita M Moschos, Michael Dimissianos, Gerasimos Georgopoulos, Ioannnis Ladas, Michael ApostolopoulosDepartment of Ophthalmology, Athens University, Athens, GreecePurpose: To investigate tumor thickness and location, the interval of time between treatment for choroidal melanoma (proton beam irradiation or enucleation) and diagnosis of metastatic disease, and rates and sites of metastasis.Design: Retrospective, interventional, noncomparative case series.Methods: Follow-up of 152 patients with primary choroidal melanoma, between 1992 and 2006 (14 years). One hundred and twenty-one patients were treated with proton beam irradiation and 31 patients were treated with enucleation. Baseline and annual or semiannual ophthalmic examination, B-scan ultrasonography, systemic and laboratory evaluations (liver enzymes, chest X-ray, ultrasonography or magnetic resonance imaging of the liver) were performed according to a standard protocol.Results: Nineteen patients (12.5%) were diagnosed with metastasis during follow-up time after treatment for choroidal melanoma. Thirteen patients (10.7%) of the irradiation group and 6 patients (19.3%) of the enucleation group were diagnosed with metastasis. Eight patients (6.6%) of the irradiation group and 5 patients (16.1%) of the enucleation group were diagnosed with liver metastasis. Ocular complications after proton beam irradiation were recorded. Fifty-nine patients (48.7%) of the irradiation group presented with cataract. Other complications were retinal detachment, retinopathy, vitreous haemorrhage, iris neovascularization, neovascular glaucoma, optic neuropathy, and corneal opacification.Conclusions: In our series, 10.7% of the irradiation group and 19.3% of the enucleation group were diagnosed with metastasis. The liver was the most common site of metastasis in both groups. Cataract was the most common complication in the irradiation group.Keywords: melanoma, metastasis, irradiation, enucleation
format	article
author	Chryssanthi Koutsandrea Marilita M Moschos Michael Dimissianos Gerasimos Georgopoulos Ioannnis Ladas Michael Apostolopoulos
author_facet	Chryssanthi Koutsandrea Marilita M Moschos Michael Dimissianos Gerasimos Georgopoulos Ioannnis Ladas Michael Apostolopoulos
author_sort	Chryssanthi Koutsandrea
title	Metastasis rates and sites after treatment for choroidal melanoma by proton beam irradiation or by enucleation
title_short	Metastasis rates and sites after treatment for choroidal melanoma by proton beam irradiation or by enucleation
title_full	Metastasis rates and sites after treatment for choroidal melanoma by proton beam irradiation or by enucleation
title_fullStr	Metastasis rates and sites after treatment for choroidal melanoma by proton beam irradiation or by enucleation
title_full_unstemmed	Metastasis rates and sites after treatment for choroidal melanoma by proton beam irradiation or by enucleation
title_sort	metastasis rates and sites after treatment for choroidal melanoma by proton beam irradiation or by enucleation
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/2ed339b1741d4d18abd5c464918a4b31
work_keys_str_mv	AT chryssanthikoutsandrea metastasisratesandsitesaftertreatmentforchoroidalmelanomabyprotonbeamirradiationorbyenucleation AT marilitammoschos metastasisratesandsitesaftertreatmentforchoroidalmelanomabyprotonbeamirradiationorbyenucleation AT michaeldimissianos metastasisratesandsitesaftertreatmentforchoroidalmelanomabyprotonbeamirradiationorbyenucleation AT gerasimosgeorgopoulos metastasisratesandsitesaftertreatmentforchoroidalmelanomabyprotonbeamirradiationorbyenucleation AT ioannnisladas metastasisratesandsitesaftertreatmentforchoroidalmelanomabyprotonbeamirradiationorbyenucleation AT michaelapostolopoulos metastasisratesandsitesaftertreatmentforchoroidalmelanomabyprotonbeamirradiationorbyenucleation
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Metastasis rates and sites after treatment for choroidal melanoma by proton beam irradiation or by enucleation

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