Expression of mRNA vascular endothelial growth factor in hypospadias patients

Abstract Background Hypospadias is a relatively common genital anomaly in humans, usually followed by inelastic dartos that causes penile chordee. Vascular endothelial growth factor (VEGF) is strongly linked to the viscoelasticity of tissues and their elastic phase. This study aimed to evaluate VEGF...

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Autores principales:	Prahara Yuri, Gunadi, Rahmadani P. Lestari, Firly P. Fardilla, Ishandono Dachlan
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Hypospadias VEGF Dartos tissue Elasticity Chordee Penile curvature Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/2ed362f173544373b81614e54c0f01b7
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spelling	oai:doaj.org-article:2ed362f173544373b81614e54c0f01b72021-11-28T12:28:06ZExpression of mRNA vascular endothelial growth factor in hypospadias patients10.1186/s12894-021-00930-41471-2490https://doaj.org/article/2ed362f173544373b81614e54c0f01b72021-11-01T00:00:00Zhttps://doi.org/10.1186/s12894-021-00930-4https://doaj.org/toc/1471-2490Abstract Background Hypospadias is a relatively common genital anomaly in humans, usually followed by inelastic dartos that causes penile chordee. Vascular endothelial growth factor (VEGF) is strongly linked to the viscoelasticity of tissues and their elastic phase. This study aimed to evaluate VEGF expressions in (1) fascia dartos between hypospadias and controls and (2) chordee severity. Methods This prospective cohort study involved 65 specimens from patients with hypospadias and ten specimens from controls. The samples were analyzed by quantitative real-time polymerase chain reaction (qPCR) for VEGF expression. Results The expressions of VEGF were not different between proximal and distal hypospadias patients and controls (fold change: distal − 0.25; fold change: proximal − 0.2; p = 0.664). The scaled expressions related to chordee severity were mild − 0.1; moderate 0.1; severe − 0.25 (p = 0.660). Conclusions VEGF expressions might not affect the severity of hypospadias and chordee, implying the pathogenesis is complex involving many growth factors. Further study with a larger sample size is necessary to clarify and confirm our findings.Prahara YuriGunadiRahmadani P. LestariFirly P. FardillaIshandono DachlanBMCarticleHypospadiasVEGFDartos tissueElasticityChordeePenile curvatureDiseases of the genitourinary system. UrologyRC870-923ENBMC Urology, Vol 21, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hypospadias VEGF Dartos tissue Elasticity Chordee Penile curvature Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Hypospadias VEGF Dartos tissue Elasticity Chordee Penile curvature Diseases of the genitourinary system. Urology RC870-923 Prahara Yuri Gunadi Rahmadani P. Lestari Firly P. Fardilla Ishandono Dachlan Expression of mRNA vascular endothelial growth factor in hypospadias patients
description	Abstract Background Hypospadias is a relatively common genital anomaly in humans, usually followed by inelastic dartos that causes penile chordee. Vascular endothelial growth factor (VEGF) is strongly linked to the viscoelasticity of tissues and their elastic phase. This study aimed to evaluate VEGF expressions in (1) fascia dartos between hypospadias and controls and (2) chordee severity. Methods This prospective cohort study involved 65 specimens from patients with hypospadias and ten specimens from controls. The samples were analyzed by quantitative real-time polymerase chain reaction (qPCR) for VEGF expression. Results The expressions of VEGF were not different between proximal and distal hypospadias patients and controls (fold change: distal − 0.25; fold change: proximal − 0.2; p = 0.664). The scaled expressions related to chordee severity were mild − 0.1; moderate 0.1; severe − 0.25 (p = 0.660). Conclusions VEGF expressions might not affect the severity of hypospadias and chordee, implying the pathogenesis is complex involving many growth factors. Further study with a larger sample size is necessary to clarify and confirm our findings.
format	article
author	Prahara Yuri Gunadi Rahmadani P. Lestari Firly P. Fardilla Ishandono Dachlan
author_facet	Prahara Yuri Gunadi Rahmadani P. Lestari Firly P. Fardilla Ishandono Dachlan
author_sort	Prahara Yuri
title	Expression of mRNA vascular endothelial growth factor in hypospadias patients
title_short	Expression of mRNA vascular endothelial growth factor in hypospadias patients
title_full	Expression of mRNA vascular endothelial growth factor in hypospadias patients
title_fullStr	Expression of mRNA vascular endothelial growth factor in hypospadias patients
title_full_unstemmed	Expression of mRNA vascular endothelial growth factor in hypospadias patients
title_sort	expression of mrna vascular endothelial growth factor in hypospadias patients
publisher	BMC
publishDate	2021
url	https://doaj.org/article/2ed362f173544373b81614e54c0f01b7
work_keys_str_mv	AT praharayuri expressionofmrnavascularendothelialgrowthfactorinhypospadiaspatients AT gunadi expressionofmrnavascularendothelialgrowthfactorinhypospadiaspatients AT rahmadaniplestari expressionofmrnavascularendothelialgrowthfactorinhypospadiaspatients AT firlypfardilla expressionofmrnavascularendothelialgrowthfactorinhypospadiaspatients AT ishandonodachlan expressionofmrnavascularendothelialgrowthfactorinhypospadiaspatients
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Expression of mRNA vascular endothelial growth factor in hypospadias patients

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