Coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth

Targeting mitochondrial metabolism in cancer cells has shown promising therapeutic potential. Here, the authors screen FDA-approved compound library and show that the β1-blocker nebivolol inhibits oxidative phosphorylation and angiogenesis in cancer cells and can be re-purposed for cancer therapy.

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Autores principales:	Cristina Nuevo-Tapioles, Fulvio Santacatterina, Konstantinos Stamatakis, Cristina Núñez de Arenas, Marta Gómez de Cedrón, Laura Formentini, José M. Cuezva
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2ed65c12406d4d79a455a9a9932bdfbd
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spelling	oai:doaj.org-article:2ed65c12406d4d79a455a9a9932bdfbd2021-12-02T16:08:15ZCoordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth10.1038/s41467-020-17384-12041-1723https://doaj.org/article/2ed65c12406d4d79a455a9a9932bdfbd2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17384-1https://doaj.org/toc/2041-1723Targeting mitochondrial metabolism in cancer cells has shown promising therapeutic potential. Here, the authors screen FDA-approved compound library and show that the β1-blocker nebivolol inhibits oxidative phosphorylation and angiogenesis in cancer cells and can be re-purposed for cancer therapy.Cristina Nuevo-TapiolesFulvio SantacatterinaKonstantinos StamatakisCristina Núñez de ArenasMarta Gómez de CedrónLaura FormentiniJosé M. CuezvaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cristina Nuevo-Tapioles Fulvio Santacatterina Konstantinos Stamatakis Cristina Núñez de Arenas Marta Gómez de Cedrón Laura Formentini José M. Cuezva Coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth
description	Targeting mitochondrial metabolism in cancer cells has shown promising therapeutic potential. Here, the authors screen FDA-approved compound library and show that the β1-blocker nebivolol inhibits oxidative phosphorylation and angiogenesis in cancer cells and can be re-purposed for cancer therapy.
format	article
author	Cristina Nuevo-Tapioles Fulvio Santacatterina Konstantinos Stamatakis Cristina Núñez de Arenas Marta Gómez de Cedrón Laura Formentini José M. Cuezva
author_facet	Cristina Nuevo-Tapioles Fulvio Santacatterina Konstantinos Stamatakis Cristina Núñez de Arenas Marta Gómez de Cedrón Laura Formentini José M. Cuezva
author_sort	Cristina Nuevo-Tapioles
title	Coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth
title_short	Coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth
title_full	Coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth
title_fullStr	Coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth
title_full_unstemmed	Coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth
title_sort	coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2ed65c12406d4d79a455a9a9932bdfbd
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Coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth

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