A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells

Many cancer cells have increased glucose consumption compared to normal cells, a feature that can be exploited therapeutically. Here, the authors carry out a chemical screen and identify compounds that selectively blocks glucose metabolism in non-small-cell lung cancer cell lines.

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Autores principales:	Chiara Ghezzi, Alicia Wong, Bao Ying Chen, Bernard Ribalet, Robert Damoiseaux, Peter M. Clark
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2eda619824de42219eeab1b51ef3beb0
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spelling	oai:doaj.org-article:2eda619824de42219eeab1b51ef3beb02021-12-02T15:35:38ZA high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells10.1038/s41467-019-13334-82041-1723https://doaj.org/article/2eda619824de42219eeab1b51ef3beb02019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13334-8https://doaj.org/toc/2041-1723Many cancer cells have increased glucose consumption compared to normal cells, a feature that can be exploited therapeutically. Here, the authors carry out a chemical screen and identify compounds that selectively blocks glucose metabolism in non-small-cell lung cancer cell lines.Chiara GhezziAlicia WongBao Ying ChenBernard RibaletRobert DamoiseauxPeter M. ClarkNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chiara Ghezzi Alicia Wong Bao Ying Chen Bernard Ribalet Robert Damoiseaux Peter M. Clark A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells
description	Many cancer cells have increased glucose consumption compared to normal cells, a feature that can be exploited therapeutically. Here, the authors carry out a chemical screen and identify compounds that selectively blocks glucose metabolism in non-small-cell lung cancer cell lines.
format	article
author	Chiara Ghezzi Alicia Wong Bao Ying Chen Bernard Ribalet Robert Damoiseaux Peter M. Clark
author_facet	Chiara Ghezzi Alicia Wong Bao Ying Chen Bernard Ribalet Robert Damoiseaux Peter M. Clark
author_sort	Chiara Ghezzi
title	A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells
title_short	A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells
title_full	A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells
title_fullStr	A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells
title_full_unstemmed	A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells
title_sort	high-throughput screen identifies that cdk7 activates glucose consumption in lung cancer cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2eda619824de42219eeab1b51ef3beb0
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A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells

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