Repatriation of a patient with COVID-19 contributed to the importation of an emerging carbapenemase producer

ABSTRACT: Objectives: Patients hospitalised abroad can become colonised with multidrug-resistant bacteria and import them to their home countries. In this study, we characterised an OXA-484 carbapenemase-producing Escherichia coli strain from a Swiss patient infected by SARS-CoV-2 and repatriated f...

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Autores principales:	Aline I. Moser, Edgar I. Campos-Madueno, Parham Sendi, Vincent Perreten, Peter M. Keller, Alban Ramette, Andrea Endimiani
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Carbapenemase OXA-48 OXA-484 Plasmid SARS-CoV-2 IncX3 Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/2edad01fbd944f5abbbbd7509563f39d
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spelling	oai:doaj.org-article:2edad01fbd944f5abbbbd7509563f39d2021-11-14T04:32:53ZRepatriation of a patient with COVID-19 contributed to the importation of an emerging carbapenemase producer2213-716510.1016/j.jgar.2021.10.012https://doaj.org/article/2edad01fbd944f5abbbbd7509563f39d2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213716521002307https://doaj.org/toc/2213-7165ABSTRACT: Objectives: Patients hospitalised abroad can become colonised with multidrug-resistant bacteria and import them to their home countries. In this study, we characterised an OXA-484 carbapenemase-producing Escherichia coli strain from a Swiss patient infected by SARS-CoV-2 and repatriated from India. Methods: At admission to Switzerland (April 2021), the patient undertook a nasopharyngeal swab to search for SARS-CoV-2 and a rectal swab to detect multidrug-resistant bacteria. Both SARS-CoV-2 and E. coli isolates were whole-genome sequenced and analysed for phylogenetic relatedness. Results: The patient was infected with the SARS-CoV-2 B.1.617.2 lineage (VOC Delta), a lineage that began to be reported across Switzerland at that time. He was also colonised with a sequence type 410 (ST410) E. coli strain (L3452210II) producing OXA-484, a single amino acid variant of OXA-181. The blaOXA-484 gene was carried by a 51.5 kb IncX3 plasmid identical to those described in blaOXA-181-harbouring ST410 E. coli strains. Core genome analysis showed that L3452210II was identical (ΔSNV ≤23) to two ST410 OXA-484 producers recently reported in Qatar and Germany, but differed from other ST410 OXA-181 producers reported worldwide. Conclusion: The patient was infected by an emerging SARS-CoV-2 variant and also imported an E. coli producing OXA-484, an OXA-48-like carbapenemase not yet reported in Switzerland. The genetic background of L3452210II indicated that blaOXA-484 shared the same plasmid as blaOXA-181, but its bacterial host differed from most of the pandemic OXA-181-producing ST410 strains reported previously. This case description underlines that the COVID-19 crisis can contribute to the worldwide spread of emerging carbapenemase producers.Aline I. MoserEdgar I. Campos-MaduenoParham SendiVincent PerretenPeter M. KellerAlban RametteAndrea EndimianiElsevierarticleCarbapenemaseOXA-48OXA-484PlasmidSARS-CoV-2IncX3MicrobiologyQR1-502ENJournal of Global Antimicrobial Resistance, Vol 27, Iss , Pp 267-272 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Carbapenemase OXA-48 OXA-484 Plasmid SARS-CoV-2 IncX3 Microbiology QR1-502
spellingShingle	Carbapenemase OXA-48 OXA-484 Plasmid SARS-CoV-2 IncX3 Microbiology QR1-502 Aline I. Moser Edgar I. Campos-Madueno Parham Sendi Vincent Perreten Peter M. Keller Alban Ramette Andrea Endimiani Repatriation of a patient with COVID-19 contributed to the importation of an emerging carbapenemase producer
description	ABSTRACT: Objectives: Patients hospitalised abroad can become colonised with multidrug-resistant bacteria and import them to their home countries. In this study, we characterised an OXA-484 carbapenemase-producing Escherichia coli strain from a Swiss patient infected by SARS-CoV-2 and repatriated from India. Methods: At admission to Switzerland (April 2021), the patient undertook a nasopharyngeal swab to search for SARS-CoV-2 and a rectal swab to detect multidrug-resistant bacteria. Both SARS-CoV-2 and E. coli isolates were whole-genome sequenced and analysed for phylogenetic relatedness. Results: The patient was infected with the SARS-CoV-2 B.1.617.2 lineage (VOC Delta), a lineage that began to be reported across Switzerland at that time. He was also colonised with a sequence type 410 (ST410) E. coli strain (L3452210II) producing OXA-484, a single amino acid variant of OXA-181. The blaOXA-484 gene was carried by a 51.5 kb IncX3 plasmid identical to those described in blaOXA-181-harbouring ST410 E. coli strains. Core genome analysis showed that L3452210II was identical (ΔSNV ≤23) to two ST410 OXA-484 producers recently reported in Qatar and Germany, but differed from other ST410 OXA-181 producers reported worldwide. Conclusion: The patient was infected by an emerging SARS-CoV-2 variant and also imported an E. coli producing OXA-484, an OXA-48-like carbapenemase not yet reported in Switzerland. The genetic background of L3452210II indicated that blaOXA-484 shared the same plasmid as blaOXA-181, but its bacterial host differed from most of the pandemic OXA-181-producing ST410 strains reported previously. This case description underlines that the COVID-19 crisis can contribute to the worldwide spread of emerging carbapenemase producers.
format	article
author	Aline I. Moser Edgar I. Campos-Madueno Parham Sendi Vincent Perreten Peter M. Keller Alban Ramette Andrea Endimiani
author_facet	Aline I. Moser Edgar I. Campos-Madueno Parham Sendi Vincent Perreten Peter M. Keller Alban Ramette Andrea Endimiani
author_sort	Aline I. Moser
title	Repatriation of a patient with COVID-19 contributed to the importation of an emerging carbapenemase producer
title_short	Repatriation of a patient with COVID-19 contributed to the importation of an emerging carbapenemase producer
title_full	Repatriation of a patient with COVID-19 contributed to the importation of an emerging carbapenemase producer
title_fullStr	Repatriation of a patient with COVID-19 contributed to the importation of an emerging carbapenemase producer
title_full_unstemmed	Repatriation of a patient with COVID-19 contributed to the importation of an emerging carbapenemase producer
title_sort	repatriation of a patient with covid-19 contributed to the importation of an emerging carbapenemase producer
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/2edad01fbd944f5abbbbd7509563f39d
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Repatriation of a patient with COVID-19 contributed to the importation of an emerging carbapenemase producer

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