Self-Medication for Chronic Pain Using Classic Psychedelics: A Qualitative Investigation to Inform Future Research

Background: Chronic Pain is among the leading causes of disability worldwide with up to 60% of patients suffering from comorbid depression. Psychedelic-assisted therapy has recently been found effective in treating a host of mental health issues including depression and has historically been found t...

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Autores principales:	Julia Bornemann, James B. Close, Meg J. Spriggs, Robin Carhart-Harris, Leor Roseman
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	psychedelic chronic pain self-medication Patient and Public Involvement (PPI) thematic analysis Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/2ede5340c67a48bbab33c53e5bc7bf47
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spelling	oai:doaj.org-article:2ede5340c67a48bbab33c53e5bc7bf472021-11-12T05:23:28ZSelf-Medication for Chronic Pain Using Classic Psychedelics: A Qualitative Investigation to Inform Future Research1664-064010.3389/fpsyt.2021.735427https://doaj.org/article/2ede5340c67a48bbab33c53e5bc7bf472021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.735427/fullhttps://doaj.org/toc/1664-0640Background: Chronic Pain is among the leading causes of disability worldwide with up to 60% of patients suffering from comorbid depression. Psychedelic-assisted therapy has recently been found effective in treating a host of mental health issues including depression and has historically been found to be useful in treating pain. Reports of self-medication for chronic pain using psychedelic drugs have been widely documented, with anecdotal evidence indicating widespread success in a range of pathologies.Aims: In preparation for an upcoming trial, to better understand how those with lived experience of chronic pain self-medicate with psychedelic drugs, and to establish, in detail, their therapeutic protocols and practices for success.Methods: As part of patient-involvement (PI) for an upcoming trial in this population, 11 individuals who reported self-medicating with psychedelic drugs took part in a 1-h semi-structured discussion, which was then transcribed and thematically analyzed.Results: Across a range of psychedelic substances and doses, reported pain scores improved substantially during and after psychedelic experiences. Two processes, Positive Reframing and Somatic Presence, were reliably identified as playing a role in improvements in mental wellbeing, relationship with pain, and physical (dis)comfort. Inclusion of other strategies such as mindfulness, breathwork, and movement were also widely reported. Due to the data's subjective nature, this paper is vulnerable to bias and makes no claims on causality or generalisability. Together, these results have been used to inform study design for a forthcoming trial.Conclusion: This pre-trial PI work gives us confidence to test psychedelic therapy for chronic pain in a forthcoming controlled trial. The results presented here will be instrumental in improving our ability to meet the needs of future study participants.Julia BornemannJames B. CloseMeg J. SpriggsRobin Carhart-HarrisRobin Carhart-HarrisLeor RosemanFrontiers Media S.A.articlepsychedelicchronic painself-medicationPatient and Public Involvement (PPI)thematic analysisPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	psychedelic chronic pain self-medication Patient and Public Involvement (PPI) thematic analysis Psychiatry RC435-571
spellingShingle	psychedelic chronic pain self-medication Patient and Public Involvement (PPI) thematic analysis Psychiatry RC435-571 Julia Bornemann James B. Close Meg J. Spriggs Robin Carhart-Harris Robin Carhart-Harris Leor Roseman Self-Medication for Chronic Pain Using Classic Psychedelics: A Qualitative Investigation to Inform Future Research
description	Background: Chronic Pain is among the leading causes of disability worldwide with up to 60% of patients suffering from comorbid depression. Psychedelic-assisted therapy has recently been found effective in treating a host of mental health issues including depression and has historically been found to be useful in treating pain. Reports of self-medication for chronic pain using psychedelic drugs have been widely documented, with anecdotal evidence indicating widespread success in a range of pathologies.Aims: In preparation for an upcoming trial, to better understand how those with lived experience of chronic pain self-medicate with psychedelic drugs, and to establish, in detail, their therapeutic protocols and practices for success.Methods: As part of patient-involvement (PI) for an upcoming trial in this population, 11 individuals who reported self-medicating with psychedelic drugs took part in a 1-h semi-structured discussion, which was then transcribed and thematically analyzed.Results: Across a range of psychedelic substances and doses, reported pain scores improved substantially during and after psychedelic experiences. Two processes, Positive Reframing and Somatic Presence, were reliably identified as playing a role in improvements in mental wellbeing, relationship with pain, and physical (dis)comfort. Inclusion of other strategies such as mindfulness, breathwork, and movement were also widely reported. Due to the data's subjective nature, this paper is vulnerable to bias and makes no claims on causality or generalisability. Together, these results have been used to inform study design for a forthcoming trial.Conclusion: This pre-trial PI work gives us confidence to test psychedelic therapy for chronic pain in a forthcoming controlled trial. The results presented here will be instrumental in improving our ability to meet the needs of future study participants.
format	article
author	Julia Bornemann James B. Close Meg J. Spriggs Robin Carhart-Harris Robin Carhart-Harris Leor Roseman
author_facet	Julia Bornemann James B. Close Meg J. Spriggs Robin Carhart-Harris Robin Carhart-Harris Leor Roseman
author_sort	Julia Bornemann
title	Self-Medication for Chronic Pain Using Classic Psychedelics: A Qualitative Investigation to Inform Future Research
title_short	Self-Medication for Chronic Pain Using Classic Psychedelics: A Qualitative Investigation to Inform Future Research
title_full	Self-Medication for Chronic Pain Using Classic Psychedelics: A Qualitative Investigation to Inform Future Research
title_fullStr	Self-Medication for Chronic Pain Using Classic Psychedelics: A Qualitative Investigation to Inform Future Research
title_full_unstemmed	Self-Medication for Chronic Pain Using Classic Psychedelics: A Qualitative Investigation to Inform Future Research
title_sort	self-medication for chronic pain using classic psychedelics: a qualitative investigation to inform future research
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2ede5340c67a48bbab33c53e5bc7bf47
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Self-Medication for Chronic Pain Using Classic Psychedelics: A Qualitative Investigation to Inform Future Research

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