Fatigue modulates dopamine availability and promotes flexible choice reversals during decision making

Abstract During decisions, animals balance goal achievement and effort management. Despite physical exercise and fatigue significantly affecting the levels of effort that an animal exerts to obtain a reward, their role in effort-based choice and the underlying neurochemistry are incompletely known....

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Autores principales:	Pierpaolo Iodice, Claudio Ferrante, Luigi Brunetti, Simona Cabib, Feliciano Protasi, Mark E. Walton, Giovanni Pezzulo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2edf0178c2a54124bda882e598b38c8a
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spelling	oai:doaj.org-article:2edf0178c2a54124bda882e598b38c8a2021-12-02T16:08:07ZFatigue modulates dopamine availability and promotes flexible choice reversals during decision making10.1038/s41598-017-00561-62045-2322https://doaj.org/article/2edf0178c2a54124bda882e598b38c8a2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00561-6https://doaj.org/toc/2045-2322Abstract During decisions, animals balance goal achievement and effort management. Despite physical exercise and fatigue significantly affecting the levels of effort that an animal exerts to obtain a reward, their role in effort-based choice and the underlying neurochemistry are incompletely known. In particular, it is unclear whether fatigue influences decision (cost-benefit) strategies flexibly or only post-decision action execution and learning. To answer this question, we trained mice on a T-maze task in which they chose between a high-cost, high-reward arm (HR), which included a barrier, and a low-cost, low-reward arm (LR), with no barrier. The animals were parametrically fatigued immediately before the behavioural tasks by running on a treadmill. We report a sharp choice reversal, from the HR to LR arm, at 80% of their peak workload (PW), which was temporary and specific, as the mice returned to choose the HC when the animals were successively tested at 60% PW or in a two-barrier task. These rapid reversals are signatures of flexible choice. We also observed increased subcortical dopamine levels in fatigued mice: a marker of individual bias to use model-based control in humans. Our results indicate that fatigue levels can be incorporated in flexible cost-benefits computations that improve foraging efficiency.Pierpaolo IodiceClaudio FerranteLuigi BrunettiSimona CabibFeliciano ProtasiMark E. WaltonGiovanni PezzuloNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pierpaolo Iodice Claudio Ferrante Luigi Brunetti Simona Cabib Feliciano Protasi Mark E. Walton Giovanni Pezzulo Fatigue modulates dopamine availability and promotes flexible choice reversals during decision making
description	Abstract During decisions, animals balance goal achievement and effort management. Despite physical exercise and fatigue significantly affecting the levels of effort that an animal exerts to obtain a reward, their role in effort-based choice and the underlying neurochemistry are incompletely known. In particular, it is unclear whether fatigue influences decision (cost-benefit) strategies flexibly or only post-decision action execution and learning. To answer this question, we trained mice on a T-maze task in which they chose between a high-cost, high-reward arm (HR), which included a barrier, and a low-cost, low-reward arm (LR), with no barrier. The animals were parametrically fatigued immediately before the behavioural tasks by running on a treadmill. We report a sharp choice reversal, from the HR to LR arm, at 80% of their peak workload (PW), which was temporary and specific, as the mice returned to choose the HC when the animals were successively tested at 60% PW or in a two-barrier task. These rapid reversals are signatures of flexible choice. We also observed increased subcortical dopamine levels in fatigued mice: a marker of individual bias to use model-based control in humans. Our results indicate that fatigue levels can be incorporated in flexible cost-benefits computations that improve foraging efficiency.
format	article
author	Pierpaolo Iodice Claudio Ferrante Luigi Brunetti Simona Cabib Feliciano Protasi Mark E. Walton Giovanni Pezzulo
author_facet	Pierpaolo Iodice Claudio Ferrante Luigi Brunetti Simona Cabib Feliciano Protasi Mark E. Walton Giovanni Pezzulo
author_sort	Pierpaolo Iodice
title	Fatigue modulates dopamine availability and promotes flexible choice reversals during decision making
title_short	Fatigue modulates dopamine availability and promotes flexible choice reversals during decision making
title_full	Fatigue modulates dopamine availability and promotes flexible choice reversals during decision making
title_fullStr	Fatigue modulates dopamine availability and promotes flexible choice reversals during decision making
title_full_unstemmed	Fatigue modulates dopamine availability and promotes flexible choice reversals during decision making
title_sort	fatigue modulates dopamine availability and promotes flexible choice reversals during decision making
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2edf0178c2a54124bda882e598b38c8a
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Fatigue modulates dopamine availability and promotes flexible choice reversals during decision making

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