Mechanism of ribosome rescue by alternative ribosome-rescue factor B

Rescue of ribosomes stalled on non-stop mRNA is essential for cell viability, and several rescue systems to resolve stalling exist in bacteria. Here, the authors use rapid kinetics and cryo-EM to reveal the pathway and selectivity mechanism of ArfB-mediated ribosome rescue.

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Autores principales:	Kai-Hsin Chan, Valentyn Petrychenko, Claudia Mueller, Cristina Maracci, Wolf Holtkamp, Daniel N. Wilson, Niels Fischer, Marina V. Rodnina
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2ee13ea8233d47ba89c88cbd83274f16
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spelling	oai:doaj.org-article:2ee13ea8233d47ba89c88cbd83274f162021-12-02T18:50:54ZMechanism of ribosome rescue by alternative ribosome-rescue factor B10.1038/s41467-020-17853-72041-1723https://doaj.org/article/2ee13ea8233d47ba89c88cbd83274f162020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17853-7https://doaj.org/toc/2041-1723Rescue of ribosomes stalled on non-stop mRNA is essential for cell viability, and several rescue systems to resolve stalling exist in bacteria. Here, the authors use rapid kinetics and cryo-EM to reveal the pathway and selectivity mechanism of ArfB-mediated ribosome rescue.Kai-Hsin ChanValentyn PetrychenkoClaudia MuellerCristina MaracciWolf HoltkampDaniel N. WilsonNiels FischerMarina V. RodninaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kai-Hsin Chan Valentyn Petrychenko Claudia Mueller Cristina Maracci Wolf Holtkamp Daniel N. Wilson Niels Fischer Marina V. Rodnina Mechanism of ribosome rescue by alternative ribosome-rescue factor B
description	Rescue of ribosomes stalled on non-stop mRNA is essential for cell viability, and several rescue systems to resolve stalling exist in bacteria. Here, the authors use rapid kinetics and cryo-EM to reveal the pathway and selectivity mechanism of ArfB-mediated ribosome rescue.
format	article
author	Kai-Hsin Chan Valentyn Petrychenko Claudia Mueller Cristina Maracci Wolf Holtkamp Daniel N. Wilson Niels Fischer Marina V. Rodnina
author_facet	Kai-Hsin Chan Valentyn Petrychenko Claudia Mueller Cristina Maracci Wolf Holtkamp Daniel N. Wilson Niels Fischer Marina V. Rodnina
author_sort	Kai-Hsin Chan
title	Mechanism of ribosome rescue by alternative ribosome-rescue factor B
title_short	Mechanism of ribosome rescue by alternative ribosome-rescue factor B
title_full	Mechanism of ribosome rescue by alternative ribosome-rescue factor B
title_fullStr	Mechanism of ribosome rescue by alternative ribosome-rescue factor B
title_full_unstemmed	Mechanism of ribosome rescue by alternative ribosome-rescue factor B
title_sort	mechanism of ribosome rescue by alternative ribosome-rescue factor b
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2ee13ea8233d47ba89c88cbd83274f16
work_keys_str_mv	AT kaihsinchan mechanismofribosomerescuebyalternativeribosomerescuefactorb AT valentynpetrychenko mechanismofribosomerescuebyalternativeribosomerescuefactorb AT claudiamueller mechanismofribosomerescuebyalternativeribosomerescuefactorb AT cristinamaracci mechanismofribosomerescuebyalternativeribosomerescuefactorb AT wolfholtkamp mechanismofribosomerescuebyalternativeribosomerescuefactorb AT danielnwilson mechanismofribosomerescuebyalternativeribosomerescuefactorb AT nielsfischer mechanismofribosomerescuebyalternativeribosomerescuefactorb AT marinavrodnina mechanismofribosomerescuebyalternativeribosomerescuefactorb
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Mechanism of ribosome rescue by alternative ribosome-rescue factor B

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