Contactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields

Peter Blümler,1 Ralf P Friedrich,2 Jorge Pereira,3 Olga Baun,1 Christoph Alexiou,2 Volker Mailänder3,4 1Institute of Physics, Johannes Gutenberg-University Mainz, Mainz, 55128, Germany; 2Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and...

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Autores principales:	Blümler P, Friedrich RP, Pereira J, Baun O, Alexiou C, Mailänder V
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	permanent magnets halbach super-paramagnetic steering targeting Medical technology R855-855.5 Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/2ee2ff9b5722487a9dc1c2e3b8a259a7
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spelling	oai:doaj.org-article:2ee2ff9b5722487a9dc1c2e3b8a259a72021-12-02T14:24:45ZContactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields1177-8903https://doaj.org/article/2ee2ff9b5722487a9dc1c2e3b8a259a72021-04-01T00:00:00Zhttps://www.dovepress.com/contactless-nanoparticle-based-guiding-of-cells-by-controllable-magnet-peer-reviewed-article-NSAhttps://doaj.org/toc/1177-8903Peter Blümler,1 Ralf P Friedrich,2 Jorge Pereira,3 Olga Baun,1 Christoph Alexiou,2 Volker Mailänder3,4 1Institute of Physics, Johannes Gutenberg-University Mainz, Mainz, 55128, Germany; 2Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung-Professorship, Universitätsklinikum Erlangen, Erlangen, 91054, Germany; 3Department of Physical Chemistry, Max Planck Institute for Polymer Research, Mainz, 55128, Germany; 4Department of Dermatology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, 55131, GermanyCorrespondence: Peter BlümlerInstitute of Physics, Johannes Gutenberg-University Mainz, Staudingerweg 7, Mainz, 55128, GermanyTel +49 6131 3924240Fax +49 6131 3925179Email bluemler@uni-mainz.deAbstract: Controlled and contactless movements of magnetic nanoparticles are crucial for fundamental biotechnological and clinical research (eg, cell manipulation and sorting, hyperthermia, and magnetic drug targeting). However, the key technological question, how to generate suitable magnetic fields on various length scales (μm–m), is still unsolved. Here, we present a system of permanent magnets which allows for steering of iron oxide nanoparticles (SPIONs) on arbitrary trajectories observable by microscopy. The movement of the particles is simply controlled by an almost force-free rotation of cylindrical arrangements of permanent magnets. The same instrument can be used to move suspended cells loaded with SPIONs along with predetermined directions. Surprisingly, it also allows for controlled movements of intracellular compartments inside of individual cells. The exclusive use of permanent magnets simplifies scaled up versions for animals or even humans, which would open the door for remotely controlled in vivo guidance of nanoparticles or micro-robots.Keywords: permanent magnets, Halbach, super-paramagnetic, steering, targetingBlümler PFriedrich RPPereira JBaun OAlexiou CMailänder VDove Medical Pressarticlepermanent magnetshalbachsuper-paramagneticsteeringtargetingMedical technologyR855-855.5Chemical technologyTP1-1185ENNanotechnology, Science and Applications, Vol Volume 14, Pp 91-100 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	permanent magnets halbach super-paramagnetic steering targeting Medical technology R855-855.5 Chemical technology TP1-1185
spellingShingle	permanent magnets halbach super-paramagnetic steering targeting Medical technology R855-855.5 Chemical technology TP1-1185 Blümler P Friedrich RP Pereira J Baun O Alexiou C Mailänder V Contactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields
description	Peter Blümler,1 Ralf P Friedrich,2 Jorge Pereira,3 Olga Baun,1 Christoph Alexiou,2 Volker Mailänder3,4 1Institute of Physics, Johannes Gutenberg-University Mainz, Mainz, 55128, Germany; 2Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung-Professorship, Universitätsklinikum Erlangen, Erlangen, 91054, Germany; 3Department of Physical Chemistry, Max Planck Institute for Polymer Research, Mainz, 55128, Germany; 4Department of Dermatology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, 55131, GermanyCorrespondence: Peter BlümlerInstitute of Physics, Johannes Gutenberg-University Mainz, Staudingerweg 7, Mainz, 55128, GermanyTel +49 6131 3924240Fax +49 6131 3925179Email bluemler@uni-mainz.deAbstract: Controlled and contactless movements of magnetic nanoparticles are crucial for fundamental biotechnological and clinical research (eg, cell manipulation and sorting, hyperthermia, and magnetic drug targeting). However, the key technological question, how to generate suitable magnetic fields on various length scales (μm–m), is still unsolved. Here, we present a system of permanent magnets which allows for steering of iron oxide nanoparticles (SPIONs) on arbitrary trajectories observable by microscopy. The movement of the particles is simply controlled by an almost force-free rotation of cylindrical arrangements of permanent magnets. The same instrument can be used to move suspended cells loaded with SPIONs along with predetermined directions. Surprisingly, it also allows for controlled movements of intracellular compartments inside of individual cells. The exclusive use of permanent magnets simplifies scaled up versions for animals or even humans, which would open the door for remotely controlled in vivo guidance of nanoparticles or micro-robots.Keywords: permanent magnets, Halbach, super-paramagnetic, steering, targeting
format	article
author	Blümler P Friedrich RP Pereira J Baun O Alexiou C Mailänder V
author_facet	Blümler P Friedrich RP Pereira J Baun O Alexiou C Mailänder V
author_sort	Blümler P
title	Contactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields
title_short	Contactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields
title_full	Contactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields
title_fullStr	Contactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields
title_full_unstemmed	Contactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields
title_sort	contactless nanoparticle-based guiding of cells by controllable magnetic fields
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/2ee2ff9b5722487a9dc1c2e3b8a259a7
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Contactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields

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