Tick Immunobiology and Extracellular Traps: An Integrative Vision to Control of Vectors

Ticks are hematophagous ectoparasites that infest a diverse number of vertebrate hosts. The tick immunobiology plays a significant role in establishing and transmitting many pathogens to their hosts. To control tick infestations, the acaricide application is a commonly used method with severe enviro...

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Autores principales:	Hugo Aguilar-Díaz, Rosa Estela Quiroz-Castañeda, Karina Salazar-Morales, Raquel Cossío-Bayúgar, Estefan Miranda-Miranda
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	anti-tick vaccines tick immune system <i>Rhipicephalus microplus</i> extracellular traps Extracellular Traps Formation (ETosis) Neutrophils Extracellular Traps Formation (NETosis) Medicine R
Acceso en línea:	https://doaj.org/article/2ee402cc26f348e088e1be7ca363c275
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spelling	oai:doaj.org-article:2ee402cc26f348e088e1be7ca363c2752021-11-25T18:38:50ZTick Immunobiology and Extracellular Traps: An Integrative Vision to Control of Vectors10.3390/pathogens101115112076-0817https://doaj.org/article/2ee402cc26f348e088e1be7ca363c2752021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1511https://doaj.org/toc/2076-0817Ticks are hematophagous ectoparasites that infest a diverse number of vertebrate hosts. The tick immunobiology plays a significant role in establishing and transmitting many pathogens to their hosts. To control tick infestations, the acaricide application is a commonly used method with severe environmental consequences and the selection of tick-resistant populations. With these drawbacks, new tick control methods need to be developed, and the immune system of ticks contains a plethora of potential candidates for vaccine design. Additionally, tick immunity is based on an orchestrated action of humoral and cellular immune responses. Therefore, the actors of these responses are the object of our study in this review since they are new targets in anti-tick vaccine design. We present their role in the immune response that positions them as feasible targets that can be blocked, inhibited, interfered with, and overexpressed, and then elucidate a new method to control tick infestations through the development of vaccines. We also propose Extracellular Traps Formation (ETosis) in ticks as a process to eliminate their natural enemies and those pathogens they transmit (vectorial capacity), which results attractive since they are a source of acting molecules with potential use as vaccines.Hugo Aguilar-DíazRosa Estela Quiroz-CastañedaKarina Salazar-MoralesRaquel Cossío-BayúgarEstefan Miranda-MirandaMDPI AGarticleanti-tick vaccinestick immune system<i>Rhipicephalus microplus</i>extracellular trapsExtracellular Traps Formation (ETosis)Neutrophils Extracellular Traps Formation (NETosis)MedicineRENPathogens, Vol 10, Iss 1511, p 1511 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti-tick vaccines tick immune system <i>Rhipicephalus microplus</i> extracellular traps Extracellular Traps Formation (ETosis) Neutrophils Extracellular Traps Formation (NETosis) Medicine R
spellingShingle	anti-tick vaccines tick immune system <i>Rhipicephalus microplus</i> extracellular traps Extracellular Traps Formation (ETosis) Neutrophils Extracellular Traps Formation (NETosis) Medicine R Hugo Aguilar-Díaz Rosa Estela Quiroz-Castañeda Karina Salazar-Morales Raquel Cossío-Bayúgar Estefan Miranda-Miranda Tick Immunobiology and Extracellular Traps: An Integrative Vision to Control of Vectors
description	Ticks are hematophagous ectoparasites that infest a diverse number of vertebrate hosts. The tick immunobiology plays a significant role in establishing and transmitting many pathogens to their hosts. To control tick infestations, the acaricide application is a commonly used method with severe environmental consequences and the selection of tick-resistant populations. With these drawbacks, new tick control methods need to be developed, and the immune system of ticks contains a plethora of potential candidates for vaccine design. Additionally, tick immunity is based on an orchestrated action of humoral and cellular immune responses. Therefore, the actors of these responses are the object of our study in this review since they are new targets in anti-tick vaccine design. We present their role in the immune response that positions them as feasible targets that can be blocked, inhibited, interfered with, and overexpressed, and then elucidate a new method to control tick infestations through the development of vaccines. We also propose Extracellular Traps Formation (ETosis) in ticks as a process to eliminate their natural enemies and those pathogens they transmit (vectorial capacity), which results attractive since they are a source of acting molecules with potential use as vaccines.
format	article
author	Hugo Aguilar-Díaz Rosa Estela Quiroz-Castañeda Karina Salazar-Morales Raquel Cossío-Bayúgar Estefan Miranda-Miranda
author_facet	Hugo Aguilar-Díaz Rosa Estela Quiroz-Castañeda Karina Salazar-Morales Raquel Cossío-Bayúgar Estefan Miranda-Miranda
author_sort	Hugo Aguilar-Díaz
title	Tick Immunobiology and Extracellular Traps: An Integrative Vision to Control of Vectors
title_short	Tick Immunobiology and Extracellular Traps: An Integrative Vision to Control of Vectors
title_full	Tick Immunobiology and Extracellular Traps: An Integrative Vision to Control of Vectors
title_fullStr	Tick Immunobiology and Extracellular Traps: An Integrative Vision to Control of Vectors
title_full_unstemmed	Tick Immunobiology and Extracellular Traps: An Integrative Vision to Control of Vectors
title_sort	tick immunobiology and extracellular traps: an integrative vision to control of vectors
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2ee402cc26f348e088e1be7ca363c275
work_keys_str_mv	AT hugoaguilardiaz tickimmunobiologyandextracellulartrapsanintegrativevisiontocontrolofvectors AT rosaestelaquirozcastaneda tickimmunobiologyandextracellulartrapsanintegrativevisiontocontrolofvectors AT karinasalazarmorales tickimmunobiologyandextracellulartrapsanintegrativevisiontocontrolofvectors AT raquelcossiobayugar tickimmunobiologyandextracellulartrapsanintegrativevisiontocontrolofvectors AT estefanmirandamiranda tickimmunobiologyandextracellulartrapsanintegrativevisiontocontrolofvectors
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Tick Immunobiology and Extracellular Traps: An Integrative Vision to Control of Vectors

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