Uric Acid Variability as a Predictive Marker of Newly Developed Cardiovascular Events in Type 2 Diabetes

Background: Cardiovascular disease (CVD) is associated with morbidity and mortality in patients with type 2 diabetes mellitus (T2D). However, the role of serum uric acid as a risk factor for developing cardiovascular disease is controversial. This study investigated whether uric acid variability was...

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Autores principales:	Hae Kyung Kim, Minyoung Lee, Yong-ho Lee, Byung-Wan Lee, Bong-Soo Cha, Eun Seok Kang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cardiovascular disease percutaneous coronary intervention diabetes mellitus type 2 uric acid variability Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/2ee9eaf8583543059845ffcc717b77b2
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spelling	oai:doaj.org-article:2ee9eaf8583543059845ffcc717b77b22021-12-02T08:43:02ZUric Acid Variability as a Predictive Marker of Newly Developed Cardiovascular Events in Type 2 Diabetes2297-055X10.3389/fcvm.2021.775753https://doaj.org/article/2ee9eaf8583543059845ffcc717b77b22021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.775753/fullhttps://doaj.org/toc/2297-055XBackground: Cardiovascular disease (CVD) is associated with morbidity and mortality in patients with type 2 diabetes mellitus (T2D). However, the role of serum uric acid as a risk factor for developing cardiovascular disease is controversial. This study investigated whether uric acid variability was associated with new-onset symptomatic CVD in patients with T2D, requiring percutaneous coronary intervention.Methods: A total of 1,071 patients were enrolled in this retrospective cross-sectional study after propensity score matching. Patients with T2D and new-onset symptomatic CVD who received percutaneous coronary intervention for the first time, and with at least three consecutive 6-monthly measurements of serum uric acid were recruited from Severance Hospital between January 2015 and December 2019. Uric acid variability was measured by average successive variability (ASV) and analyzed to evaluate a possible correlation with the risk of developing CVD.Results: The patients were divided into quartiles based on the uric acid variability. Patients in the highest quartile were older and presented lower renal function and a higher mortality from CVD. There was a linear association between a high uric acid variability and the development of CVD. Compared to the lowest quartile, patients in the higher quartiles had a higher risk of CVD [quartile 3: adjusted odds ratio (aOR) = 1.76; 95% confidence interval (CI), 1.20–2.82; P = 0.019; quartile 4 aOR = 2.89; 95% CI, 1.74–4.80; P < 0.001].Conclusion: High uric acid variability is independently associated with an increased risk of new-onset symptomatic CVD requiring percutaneous coronary intervention in patients with T2D. Thus, maintaining serum uric acid in a narrow range by prescribing effective medications is essential to prevent new-onset CVD in patients with T2D. Nonetheless, the potential use of uric acid variability as a predictive marker of CVD in patients with T2D needs further validation.Hae Kyung KimMinyoung LeeYong-ho LeeYong-ho LeeByung-Wan LeeByung-Wan LeeBong-Soo ChaBong-Soo ChaEun Seok KangEun Seok KangFrontiers Media S.A.articlecardiovascular diseasepercutaneous coronary interventiondiabetes mellitus type 2uric acidvariabilityDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiovascular disease percutaneous coronary intervention diabetes mellitus type 2 uric acid variability Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	cardiovascular disease percutaneous coronary intervention diabetes mellitus type 2 uric acid variability Diseases of the circulatory (Cardiovascular) system RC666-701 Hae Kyung Kim Minyoung Lee Yong-ho Lee Yong-ho Lee Byung-Wan Lee Byung-Wan Lee Bong-Soo Cha Bong-Soo Cha Eun Seok Kang Eun Seok Kang Uric Acid Variability as a Predictive Marker of Newly Developed Cardiovascular Events in Type 2 Diabetes
description	Background: Cardiovascular disease (CVD) is associated with morbidity and mortality in patients with type 2 diabetes mellitus (T2D). However, the role of serum uric acid as a risk factor for developing cardiovascular disease is controversial. This study investigated whether uric acid variability was associated with new-onset symptomatic CVD in patients with T2D, requiring percutaneous coronary intervention.Methods: A total of 1,071 patients were enrolled in this retrospective cross-sectional study after propensity score matching. Patients with T2D and new-onset symptomatic CVD who received percutaneous coronary intervention for the first time, and with at least three consecutive 6-monthly measurements of serum uric acid were recruited from Severance Hospital between January 2015 and December 2019. Uric acid variability was measured by average successive variability (ASV) and analyzed to evaluate a possible correlation with the risk of developing CVD.Results: The patients were divided into quartiles based on the uric acid variability. Patients in the highest quartile were older and presented lower renal function and a higher mortality from CVD. There was a linear association between a high uric acid variability and the development of CVD. Compared to the lowest quartile, patients in the higher quartiles had a higher risk of CVD [quartile 3: adjusted odds ratio (aOR) = 1.76; 95% confidence interval (CI), 1.20–2.82; P = 0.019; quartile 4 aOR = 2.89; 95% CI, 1.74–4.80; P < 0.001].Conclusion: High uric acid variability is independently associated with an increased risk of new-onset symptomatic CVD requiring percutaneous coronary intervention in patients with T2D. Thus, maintaining serum uric acid in a narrow range by prescribing effective medications is essential to prevent new-onset CVD in patients with T2D. Nonetheless, the potential use of uric acid variability as a predictive marker of CVD in patients with T2D needs further validation.
format	article
author	Hae Kyung Kim Minyoung Lee Yong-ho Lee Yong-ho Lee Byung-Wan Lee Byung-Wan Lee Bong-Soo Cha Bong-Soo Cha Eun Seok Kang Eun Seok Kang
author_facet	Hae Kyung Kim Minyoung Lee Yong-ho Lee Yong-ho Lee Byung-Wan Lee Byung-Wan Lee Bong-Soo Cha Bong-Soo Cha Eun Seok Kang Eun Seok Kang
author_sort	Hae Kyung Kim
title	Uric Acid Variability as a Predictive Marker of Newly Developed Cardiovascular Events in Type 2 Diabetes
title_short	Uric Acid Variability as a Predictive Marker of Newly Developed Cardiovascular Events in Type 2 Diabetes
title_full	Uric Acid Variability as a Predictive Marker of Newly Developed Cardiovascular Events in Type 2 Diabetes
title_fullStr	Uric Acid Variability as a Predictive Marker of Newly Developed Cardiovascular Events in Type 2 Diabetes
title_full_unstemmed	Uric Acid Variability as a Predictive Marker of Newly Developed Cardiovascular Events in Type 2 Diabetes
title_sort	uric acid variability as a predictive marker of newly developed cardiovascular events in type 2 diabetes
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2ee9eaf8583543059845ffcc717b77b2
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Uric Acid Variability as a Predictive Marker of Newly Developed Cardiovascular Events in Type 2 Diabetes

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