LINC00998 functions as a novel tumor suppressor in acute myeloid leukemia via regulating the ZFP36 ring finger protein/mammalian target of rapamycin complex 2 axis

Acute myeloid leukemia (AML) is a severe hematologic malignancy that threatens human health. Long non-coding RNA (lncRNA) is emerged as a key player in human cancer. Herein, we explored the role of LINC00998 in human AML. LINC00998 was significantly decreased in human AML, which was linked to relaps...

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Autores principales:	Ximin Fang, Xiazhen Pan, Huirong Mai, Xiuli Yuan, Sixi Liu, Feiqiu Wen
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	lncrna acute myeloid leukemia mrna decay prognosis Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/2eea1682d7db468a9b4d82084681faad
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spelling	oai:doaj.org-article:2eea1682d7db468a9b4d82084681faad2021-11-04T15:51:54ZLINC00998 functions as a novel tumor suppressor in acute myeloid leukemia via regulating the ZFP36 ring finger protein/mammalian target of rapamycin complex 2 axis2165-59792165-598710.1080/21655979.2021.1996506https://doaj.org/article/2eea1682d7db468a9b4d82084681faad2021-10-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1996506https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Acute myeloid leukemia (AML) is a severe hematologic malignancy that threatens human health. Long non-coding RNA (lncRNA) is emerged as a key player in human cancer. Herein, we explored the role of LINC00998 in human AML. LINC00998 was significantly decreased in human AML, which was linked to relapse and poor prognosis. Stable overexpression of LINC00998 inhibited AML cell viability, colony ability, DNA synthesis rate and increased apoptosis. LINC00998 was mainly located in the cytoplasm, in which interacted with ZFP36 ring finger protein (ZFP36), a mRNA destabilizing factor, resulting in increased decay of mammalian target of rapamycin complex 2 (mTORC2), a well-known proto-oncogene in AML. Overexpression of mTORC2 partly blocked the tumor suppressive effects of LINC00998. Importantly, LINC00998 shortened in vivo AML cell survival in xenograft tumor model. Taken together, we found that LINC00998 is a novel tumor-inhibiting lncRNA in human AML. The dysregulation of LINC00998/ZFP36/mTORC2 axis is linked to leukemogenesis and progression.Ximin FangXiazhen PanHuirong MaiXiuli YuanSixi LiuFeiqiu WenTaylor & Francis Grouparticlelncrnaacute myeloid leukemiamrna decayprognosisBiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lncrna acute myeloid leukemia mrna decay prognosis Biotechnology TP248.13-248.65
spellingShingle	lncrna acute myeloid leukemia mrna decay prognosis Biotechnology TP248.13-248.65 Ximin Fang Xiazhen Pan Huirong Mai Xiuli Yuan Sixi Liu Feiqiu Wen LINC00998 functions as a novel tumor suppressor in acute myeloid leukemia via regulating the ZFP36 ring finger protein/mammalian target of rapamycin complex 2 axis
description	Acute myeloid leukemia (AML) is a severe hematologic malignancy that threatens human health. Long non-coding RNA (lncRNA) is emerged as a key player in human cancer. Herein, we explored the role of LINC00998 in human AML. LINC00998 was significantly decreased in human AML, which was linked to relapse and poor prognosis. Stable overexpression of LINC00998 inhibited AML cell viability, colony ability, DNA synthesis rate and increased apoptosis. LINC00998 was mainly located in the cytoplasm, in which interacted with ZFP36 ring finger protein (ZFP36), a mRNA destabilizing factor, resulting in increased decay of mammalian target of rapamycin complex 2 (mTORC2), a well-known proto-oncogene in AML. Overexpression of mTORC2 partly blocked the tumor suppressive effects of LINC00998. Importantly, LINC00998 shortened in vivo AML cell survival in xenograft tumor model. Taken together, we found that LINC00998 is a novel tumor-inhibiting lncRNA in human AML. The dysregulation of LINC00998/ZFP36/mTORC2 axis is linked to leukemogenesis and progression.
format	article
author	Ximin Fang Xiazhen Pan Huirong Mai Xiuli Yuan Sixi Liu Feiqiu Wen
author_facet	Ximin Fang Xiazhen Pan Huirong Mai Xiuli Yuan Sixi Liu Feiqiu Wen
author_sort	Ximin Fang
title	LINC00998 functions as a novel tumor suppressor in acute myeloid leukemia via regulating the ZFP36 ring finger protein/mammalian target of rapamycin complex 2 axis
title_short	LINC00998 functions as a novel tumor suppressor in acute myeloid leukemia via regulating the ZFP36 ring finger protein/mammalian target of rapamycin complex 2 axis
title_full	LINC00998 functions as a novel tumor suppressor in acute myeloid leukemia via regulating the ZFP36 ring finger protein/mammalian target of rapamycin complex 2 axis
title_fullStr	LINC00998 functions as a novel tumor suppressor in acute myeloid leukemia via regulating the ZFP36 ring finger protein/mammalian target of rapamycin complex 2 axis
title_full_unstemmed	LINC00998 functions as a novel tumor suppressor in acute myeloid leukemia via regulating the ZFP36 ring finger protein/mammalian target of rapamycin complex 2 axis
title_sort	linc00998 functions as a novel tumor suppressor in acute myeloid leukemia via regulating the zfp36 ring finger protein/mammalian target of rapamycin complex 2 axis
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/2eea1682d7db468a9b4d82084681faad
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LINC00998 functions as a novel tumor suppressor in acute myeloid leukemia via regulating the ZFP36 ring finger protein/mammalian target of rapamycin complex 2 axis

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