Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations

The main cell types involved in autism spectrum disorders through elevated protein synthesis are not well identified. Here, the authors show that overexpression of translation initiation factor eIF4E in microglia results in autism-like behaviour in male, but not female, mice.

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Autores principales:	Zhi-Xiang Xu, Gyu Hyun Kim, Ji-Wei Tan, Anna E. Riso, Ye Sun, Ethan Y. Xu, Guey-Ying Liao, Haifei Xu, Sang-Hoon Lee, Na-Young Do, Chan Hee Lee, Amy E. Clipperton-Allen, Soonwook Kwon, Damon T. Page, Kea Joo Lee, Baoji Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2eeb7a9bfcc54e13b36e4785832892af
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spelling	oai:doaj.org-article:2eeb7a9bfcc54e13b36e4785832892af2021-12-02T17:32:42ZElevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations10.1038/s41467-020-15530-32041-1723https://doaj.org/article/2eeb7a9bfcc54e13b36e4785832892af2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15530-3https://doaj.org/toc/2041-1723The main cell types involved in autism spectrum disorders through elevated protein synthesis are not well identified. Here, the authors show that overexpression of translation initiation factor eIF4E in microglia results in autism-like behaviour in male, but not female, mice.Zhi-Xiang XuGyu Hyun KimJi-Wei TanAnna E. RisoYe SunEthan Y. XuGuey-Ying LiaoHaifei XuSang-Hoon LeeNa-Young DoChan Hee LeeAmy E. Clipperton-AllenSoonwook KwonDamon T. PageKea Joo LeeBaoji XuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhi-Xiang Xu Gyu Hyun Kim Ji-Wei Tan Anna E. Riso Ye Sun Ethan Y. Xu Guey-Ying Liao Haifei Xu Sang-Hoon Lee Na-Young Do Chan Hee Lee Amy E. Clipperton-Allen Soonwook Kwon Damon T. Page Kea Joo Lee Baoji Xu Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations
description	The main cell types involved in autism spectrum disorders through elevated protein synthesis are not well identified. Here, the authors show that overexpression of translation initiation factor eIF4E in microglia results in autism-like behaviour in male, but not female, mice.
format	article
author	Zhi-Xiang Xu Gyu Hyun Kim Ji-Wei Tan Anna E. Riso Ye Sun Ethan Y. Xu Guey-Ying Liao Haifei Xu Sang-Hoon Lee Na-Young Do Chan Hee Lee Amy E. Clipperton-Allen Soonwook Kwon Damon T. Page Kea Joo Lee Baoji Xu
author_facet	Zhi-Xiang Xu Gyu Hyun Kim Ji-Wei Tan Anna E. Riso Ye Sun Ethan Y. Xu Guey-Ying Liao Haifei Xu Sang-Hoon Lee Na-Young Do Chan Hee Lee Amy E. Clipperton-Allen Soonwook Kwon Damon T. Page Kea Joo Lee Baoji Xu
author_sort	Zhi-Xiang Xu
title	Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations
title_short	Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations
title_full	Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations
title_fullStr	Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations
title_full_unstemmed	Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations
title_sort	elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2eeb7a9bfcc54e13b36e4785832892af
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Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations

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