Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease
Drugs targeting cardiovascular disease (CVD) can have negative consequences for liver function. Here, the authors combine genome wide analyses on 69,479 individuals to identify loss-of-function variants with beneficial effects on CVD-related traits without negative impacts on liver function.
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Nature Portfolio
2020
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oai:doaj.org-article:2eecf9230b454b46b95b45b0f20ddd2e2021-12-02T13:24:23ZLoss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease10.1038/s41467-020-20086-32041-1723https://doaj.org/article/2eecf9230b454b46b95b45b0f20ddd2e2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20086-3https://doaj.org/toc/2041-1723Drugs targeting cardiovascular disease (CVD) can have negative consequences for liver function. Here, the authors combine genome wide analyses on 69,479 individuals to identify loss-of-function variants with beneficial effects on CVD-related traits without negative impacts on liver function.Jonas B. NielsenOren RomIda SurakkaSarah E. GrahamWei ZhouTanmoy RoychowdhuryLars G. FritscheSarah A. Gagliano TaliunCarlo SidoreYuhao LiuMaiken E. GabrielsenAnne Heidi SkogholtBrooke WolfordWilliam OvertonYing ZhaoJin ChenHe ZhangWhitney E. HornsbyAkua AcheampongAusten GroomsAmanda SchaeferGregory J. M. ZajacLuis VillacortaJifeng ZhangBen BrumptonMari LøsetVivek RaiPia R. LundegaardMorten S. OlesenKent D. TaylorNicholette D. PalmerYii-Der ChenSeung H. ChoiSteven A. LubitzPatrick T. EllinorKathleen C. BarnesMichelle DayaNicholas RafaelsScott T. WeissJessica Lasky-SuRussell P. TracyRamachandran S. VasanL. Adrienne CupplesRasika A. MathiasLisa R. YanekLewis C. BeckerPatricia A. PeyserLawrence F. BielakJennifer A. SmithStella AslibekyanBertha A. HidalgoDonna K. ArnettMarguerite R. IrvinJames G. WilsonSolomon K. MusaniAdolfo CorreaStephen S. RichXiuqing GuoJerome I. RotterBarbara A. KonkleJill M. JohnsenAllison E. Ashley-KochMarilyn J. TelenVivien A. SheehanJohn BlangeroJoanne E. CurranJuan M. PeraltaCourtney MontgomeryWayne H-H SheuRen-Hua ChungKaren SchwanderSeyed M. NouraieVictor R. GordeukYingze ZhangCharles KooperbergAlexander P. ReinerRebecca D. JacksonEugene R. BleeckerDeborah A. MeyersXingnan LiSayantan DasKetian YuJonathon LeFaiveAlbert SmithTom BlackwellDaniel TaliunSebastian ZollnerLukas ForerSebastian SchoenherrChristian FuchsbergerAnita PanditMatthew ZawistowskiSachin KheterpalChad M. BrummettPradeep NatarajanDavid SchlessingerSeunggeun LeeHyun Min KangFrancesco CuccaOddgeir L. HolmenBjørn O. ÅsvoldMichael BoehnkeSekar KathiresanGoncalo R. AbecasisY. Eugene ChenCristen J. WillerKristian HveemNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
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DOAJ |
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DOAJ |
| language |
EN |
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Science Q |
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Science Q Jonas B. Nielsen Oren Rom Ida Surakka Sarah E. Graham Wei Zhou Tanmoy Roychowdhury Lars G. Fritsche Sarah A. Gagliano Taliun Carlo Sidore Yuhao Liu Maiken E. Gabrielsen Anne Heidi Skogholt Brooke Wolford William Overton Ying Zhao Jin Chen He Zhang Whitney E. Hornsby Akua Acheampong Austen Grooms Amanda Schaefer Gregory J. M. Zajac Luis Villacorta Jifeng Zhang Ben Brumpton Mari Løset Vivek Rai Pia R. Lundegaard Morten S. Olesen Kent D. Taylor Nicholette D. Palmer Yii-Der Chen Seung H. Choi Steven A. Lubitz Patrick T. Ellinor Kathleen C. Barnes Michelle Daya Nicholas Rafaels Scott T. Weiss Jessica Lasky-Su Russell P. Tracy Ramachandran S. Vasan L. Adrienne Cupples Rasika A. Mathias Lisa R. Yanek Lewis C. Becker Patricia A. Peyser Lawrence F. Bielak Jennifer A. Smith Stella Aslibekyan Bertha A. Hidalgo Donna K. Arnett Marguerite R. Irvin James G. Wilson Solomon K. Musani Adolfo Correa Stephen S. Rich Xiuqing Guo Jerome I. Rotter Barbara A. Konkle Jill M. Johnsen Allison E. Ashley-Koch Marilyn J. Telen Vivien A. Sheehan John Blangero Joanne E. Curran Juan M. Peralta Courtney Montgomery Wayne H-H Sheu Ren-Hua Chung Karen Schwander Seyed M. Nouraie Victor R. Gordeuk Yingze Zhang Charles Kooperberg Alexander P. Reiner Rebecca D. Jackson Eugene R. Bleecker Deborah A. Meyers Xingnan Li Sayantan Das Ketian Yu Jonathon LeFaive Albert Smith Tom Blackwell Daniel Taliun Sebastian Zollner Lukas Forer Sebastian Schoenherr Christian Fuchsberger Anita Pandit Matthew Zawistowski Sachin Kheterpal Chad M. Brummett Pradeep Natarajan David Schlessinger Seunggeun Lee Hyun Min Kang Francesco Cucca Oddgeir L. Holmen Bjørn O. Åsvold Michael Boehnke Sekar Kathiresan Goncalo R. Abecasis Y. Eugene Chen Cristen J. Willer Kristian Hveem Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease |
| description |
Drugs targeting cardiovascular disease (CVD) can have negative consequences for liver function. Here, the authors combine genome wide analyses on 69,479 individuals to identify loss-of-function variants with beneficial effects on CVD-related traits without negative impacts on liver function. |
| format |
article |
| author |
Jonas B. Nielsen Oren Rom Ida Surakka Sarah E. Graham Wei Zhou Tanmoy Roychowdhury Lars G. Fritsche Sarah A. Gagliano Taliun Carlo Sidore Yuhao Liu Maiken E. Gabrielsen Anne Heidi Skogholt Brooke Wolford William Overton Ying Zhao Jin Chen He Zhang Whitney E. Hornsby Akua Acheampong Austen Grooms Amanda Schaefer Gregory J. M. Zajac Luis Villacorta Jifeng Zhang Ben Brumpton Mari Løset Vivek Rai Pia R. Lundegaard Morten S. Olesen Kent D. Taylor Nicholette D. Palmer Yii-Der Chen Seung H. Choi Steven A. Lubitz Patrick T. Ellinor Kathleen C. Barnes Michelle Daya Nicholas Rafaels Scott T. Weiss Jessica Lasky-Su Russell P. Tracy Ramachandran S. Vasan L. Adrienne Cupples Rasika A. Mathias Lisa R. Yanek Lewis C. Becker Patricia A. Peyser Lawrence F. Bielak Jennifer A. Smith Stella Aslibekyan Bertha A. Hidalgo Donna K. Arnett Marguerite R. Irvin James G. Wilson Solomon K. Musani Adolfo Correa Stephen S. Rich Xiuqing Guo Jerome I. Rotter Barbara A. Konkle Jill M. Johnsen Allison E. Ashley-Koch Marilyn J. Telen Vivien A. Sheehan John Blangero Joanne E. Curran Juan M. Peralta Courtney Montgomery Wayne H-H Sheu Ren-Hua Chung Karen Schwander Seyed M. Nouraie Victor R. Gordeuk Yingze Zhang Charles Kooperberg Alexander P. Reiner Rebecca D. Jackson Eugene R. Bleecker Deborah A. Meyers Xingnan Li Sayantan Das Ketian Yu Jonathon LeFaive Albert Smith Tom Blackwell Daniel Taliun Sebastian Zollner Lukas Forer Sebastian Schoenherr Christian Fuchsberger Anita Pandit Matthew Zawistowski Sachin Kheterpal Chad M. Brummett Pradeep Natarajan David Schlessinger Seunggeun Lee Hyun Min Kang Francesco Cucca Oddgeir L. Holmen Bjørn O. Åsvold Michael Boehnke Sekar Kathiresan Goncalo R. Abecasis Y. Eugene Chen Cristen J. Willer Kristian Hveem |
| author_facet |
Jonas B. Nielsen Oren Rom Ida Surakka Sarah E. Graham Wei Zhou Tanmoy Roychowdhury Lars G. Fritsche Sarah A. Gagliano Taliun Carlo Sidore Yuhao Liu Maiken E. Gabrielsen Anne Heidi Skogholt Brooke Wolford William Overton Ying Zhao Jin Chen He Zhang Whitney E. Hornsby Akua Acheampong Austen Grooms Amanda Schaefer Gregory J. M. Zajac Luis Villacorta Jifeng Zhang Ben Brumpton Mari Løset Vivek Rai Pia R. Lundegaard Morten S. Olesen Kent D. Taylor Nicholette D. Palmer Yii-Der Chen Seung H. Choi Steven A. Lubitz Patrick T. Ellinor Kathleen C. Barnes Michelle Daya Nicholas Rafaels Scott T. Weiss Jessica Lasky-Su Russell P. Tracy Ramachandran S. Vasan L. Adrienne Cupples Rasika A. Mathias Lisa R. Yanek Lewis C. Becker Patricia A. Peyser Lawrence F. Bielak Jennifer A. Smith Stella Aslibekyan Bertha A. Hidalgo Donna K. Arnett Marguerite R. Irvin James G. Wilson Solomon K. Musani Adolfo Correa Stephen S. Rich Xiuqing Guo Jerome I. Rotter Barbara A. Konkle Jill M. Johnsen Allison E. Ashley-Koch Marilyn J. Telen Vivien A. Sheehan John Blangero Joanne E. Curran Juan M. Peralta Courtney Montgomery Wayne H-H Sheu Ren-Hua Chung Karen Schwander Seyed M. Nouraie Victor R. Gordeuk Yingze Zhang Charles Kooperberg Alexander P. Reiner Rebecca D. Jackson Eugene R. Bleecker Deborah A. Meyers Xingnan Li Sayantan Das Ketian Yu Jonathon LeFaive Albert Smith Tom Blackwell Daniel Taliun Sebastian Zollner Lukas Forer Sebastian Schoenherr Christian Fuchsberger Anita Pandit Matthew Zawistowski Sachin Kheterpal Chad M. Brummett Pradeep Natarajan David Schlessinger Seunggeun Lee Hyun Min Kang Francesco Cucca Oddgeir L. Holmen Bjørn O. Åsvold Michael Boehnke Sekar Kathiresan Goncalo R. Abecasis Y. Eugene Chen Cristen J. Willer Kristian Hveem |
| author_sort |
Jonas B. Nielsen |
| title |
Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease |
| title_short |
Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease |
| title_full |
Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease |
| title_fullStr |
Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease |
| title_full_unstemmed |
Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease |
| title_sort |
loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/2eecf9230b454b46b95b45b0f20ddd2e |
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