Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc

MepS is a peptidoglycan (PG) cross-link specific hydrolase needed for cell wall expansion and its cellular levels must be tightly regulated. Here the authors present the structure of the MepS degrading protease Prc bound to its adaptor NlpI and propose a model how the NlpI-Prc complex mediates MepS...

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Auteurs principaux:	Ming-Yuan Su, Nilanjan Som, Chia-Yun Wu, Shih-Chieh Su, Yi-Ting Kuo, Lu-Chu Ke, Meng-Ru Ho, Shiou-Ru Tzeng, Ching-Hao Teng, Dominique Mengin-Lecreulx, Manjula Reddy, Chung-I Chang
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/2eee51eaba5b45a6a5a94b3bbceba1cd
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spelling	oai:doaj.org-article:2eee51eaba5b45a6a5a94b3bbceba1cd2021-12-02T14:42:26ZStructural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc10.1038/s41467-017-01697-92041-1723https://doaj.org/article/2eee51eaba5b45a6a5a94b3bbceba1cd2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01697-9https://doaj.org/toc/2041-1723MepS is a peptidoglycan (PG) cross-link specific hydrolase needed for cell wall expansion and its cellular levels must be tightly regulated. Here the authors present the structure of the MepS degrading protease Prc bound to its adaptor NlpI and propose a model how the NlpI-Prc complex mediates MepS degradation.Ming-Yuan SuNilanjan SomChia-Yun WuShih-Chieh SuYi-Ting KuoLu-Chu KeMeng-Ru HoShiou-Ru TzengChing-Hao TengDominique Mengin-LecreulxManjula ReddyChung-I ChangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ming-Yuan Su Nilanjan Som Chia-Yun Wu Shih-Chieh Su Yi-Ting Kuo Lu-Chu Ke Meng-Ru Ho Shiou-Ru Tzeng Ching-Hao Teng Dominique Mengin-Lecreulx Manjula Reddy Chung-I Chang Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc
description	MepS is a peptidoglycan (PG) cross-link specific hydrolase needed for cell wall expansion and its cellular levels must be tightly regulated. Here the authors present the structure of the MepS degrading protease Prc bound to its adaptor NlpI and propose a model how the NlpI-Prc complex mediates MepS degradation.
format	article
author	Ming-Yuan Su Nilanjan Som Chia-Yun Wu Shih-Chieh Su Yi-Ting Kuo Lu-Chu Ke Meng-Ru Ho Shiou-Ru Tzeng Ching-Hao Teng Dominique Mengin-Lecreulx Manjula Reddy Chung-I Chang
author_facet	Ming-Yuan Su Nilanjan Som Chia-Yun Wu Shih-Chieh Su Yi-Ting Kuo Lu-Chu Ke Meng-Ru Ho Shiou-Ru Tzeng Ching-Hao Teng Dominique Mengin-Lecreulx Manjula Reddy Chung-I Chang
author_sort	Ming-Yuan Su
title	Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc
title_short	Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc
title_full	Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc
title_fullStr	Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc
title_full_unstemmed	Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc
title_sort	structural basis of adaptor-mediated protein degradation by the tail-specific pdz-protease prc
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2eee51eaba5b45a6a5a94b3bbceba1cd
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Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc

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