Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva.

Nodal and BMP signals are important for establishing left-right (LR) asymmetry in vertebrates. In sea urchins, Nodal signaling prevents the formation of the rudiment on the right side. However, the opposing pathway to Nodal signaling during LR axis establishment is not clear. Here, we revealed that...

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Autores principales:	Yi-Jyun Luo, Yi-Hsien Su
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2eefdd5c912c444cb2652cf248d52bf6
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spelling	oai:doaj.org-article:2eefdd5c912c444cb2652cf248d52bf62021-11-18T05:37:24ZOpposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva.1544-91731545-788510.1371/journal.pbio.1001402https://doaj.org/article/2eefdd5c912c444cb2652cf248d52bf62012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23055827/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Nodal and BMP signals are important for establishing left-right (LR) asymmetry in vertebrates. In sea urchins, Nodal signaling prevents the formation of the rudiment on the right side. However, the opposing pathway to Nodal signaling during LR axis establishment is not clear. Here, we revealed that BMP signaling is activated in the left coelomic pouch, specifically in the veg2 lineage, but not in the small micromeres. By perturbing BMP activities, we demonstrated that BMP signaling is required for activating the expression of the left-sided genes and the formation of the left-sided structures. On the other hand, Nodal signals on the right side inhibit BMP signaling and control LR asymmetric separation and apoptosis of the small micromeres. Our findings show that BMP signaling is the positive signal for left-sided development in sea urchins, suggesting that the opposing roles of Nodal and BMP signals in establishing LR asymmetry are conserved in deuterostomes.Yi-Jyun LuoYi-Hsien SuPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 10, Iss 10, p e1001402 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yi-Jyun Luo Yi-Hsien Su Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva.
description	Nodal and BMP signals are important for establishing left-right (LR) asymmetry in vertebrates. In sea urchins, Nodal signaling prevents the formation of the rudiment on the right side. However, the opposing pathway to Nodal signaling during LR axis establishment is not clear. Here, we revealed that BMP signaling is activated in the left coelomic pouch, specifically in the veg2 lineage, but not in the small micromeres. By perturbing BMP activities, we demonstrated that BMP signaling is required for activating the expression of the left-sided genes and the formation of the left-sided structures. On the other hand, Nodal signals on the right side inhibit BMP signaling and control LR asymmetric separation and apoptosis of the small micromeres. Our findings show that BMP signaling is the positive signal for left-sided development in sea urchins, suggesting that the opposing roles of Nodal and BMP signals in establishing LR asymmetry are conserved in deuterostomes.
format	article
author	Yi-Jyun Luo Yi-Hsien Su
author_facet	Yi-Jyun Luo Yi-Hsien Su
author_sort	Yi-Jyun Luo
title	Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva.
title_short	Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva.
title_full	Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva.
title_fullStr	Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva.
title_full_unstemmed	Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva.
title_sort	opposing nodal and bmp signals regulate left-right asymmetry in the sea urchin larva.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/2eefdd5c912c444cb2652cf248d52bf6
work_keys_str_mv	AT yijyunluo opposingnodalandbmpsignalsregulateleftrightasymmetryintheseaurchinlarva AT yihsiensu opposingnodalandbmpsignalsregulateleftrightasymmetryintheseaurchinlarva
_version_	1718424839986872320

Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva.

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