ROLE OF MODERN IMMUNOLOGIC TESTS IN DIAGNOSTICS OF TUBERCULOSIS IN CHILDREN

Present study has revealed low diagnostic value of Mantoux test with 2 TE in detection of tuberculosis in MBT-infected children, thus requiring implementation of novel methods. Detectable activity of tuberculosis infection among observed children with low tuberculin sensitivity was found in 23.8% of...

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Autores principales: P. K. Iablonskiy, I. F. Dovgaljuk, A. A. Starshinova, O. A. Iakunova
Formato: article
Lenguaje:RU
Publicado: SPb RAACI 2014
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Acceso en línea:https://doaj.org/article/2ef57e2e64044786ba85ee148241c8d8
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Sumario:Present study has revealed low diagnostic value of Mantoux test with 2 TE in detection of tuberculosis in MBT-infected children, thus requiring implementation of novel methods. Detectable activity of tuberculosis infection among observed children with low tuberculin sensitivity was found in 23.8% of cases, as revealed by Diaskin test, as compared to 42.7% cases in a group with moderate sensitivity to tuberculin. As shown by radiological data it was accompanied by enlargement of intrathoracic lymphatic nodes in 14.3% and 53.0% cases, respectively. The data obtained with Diaskin probe were confirmed by a reference QuantiFERON testing in 95% cases. Parameters of diagnostic value for Diaskin test are two-fold higher than for Mantoux test with 2 TE. Positivity for Diaskin test reflects activity of tuberculosis infection which is accompanied by clear clinical signs in 67.3% cases, and, in 80% cases, it ischaracterized by enlargement of intrathoracic lymphatic nodes as based on radiologic data, thus arranging a risk group for tuberculosis morbidity in children. Appropriate recommendations for these patients include a fullscale phthisiatric assessment and administration of well justified and adequate therapy.