ROLE OF MODERN IMMUNOLOGIC TESTS IN DIAGNOSTICS OF TUBERCULOSIS IN CHILDREN

Present study has revealed low diagnostic value of Mantoux test with 2 TE in detection of tuberculosis in MBT-infected children, thus requiring implementation of novel methods. Detectable activity of tuberculosis infection among observed children with low tuberculin sensitivity was found in 23.8% of...

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Autores principales:	P. K. Iablonskiy, I. F. Dovgaljuk, A. A. Starshinova, O. A. Iakunova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	tuberculosis children diaskin test computer tomography diagnostics Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/2ef57e2e64044786ba85ee148241c8d8
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spelling	oai:doaj.org-article:2ef57e2e64044786ba85ee148241c8d82021-11-18T08:03:37ZROLE OF MODERN IMMUNOLOGIC TESTS IN DIAGNOSTICS OF TUBERCULOSIS IN CHILDREN1563-06252313-741X10.15789/1563-0625-2013-1-37-44https://doaj.org/article/2ef57e2e64044786ba85ee148241c8d82014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/47https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XPresent study has revealed low diagnostic value of Mantoux test with 2 TE in detection of tuberculosis in MBT-infected children, thus requiring implementation of novel methods. Detectable activity of tuberculosis infection among observed children with low tuberculin sensitivity was found in 23.8% of cases, as revealed by Diaskin test, as compared to 42.7% cases in a group with moderate sensitivity to tuberculin. As shown by radiological data it was accompanied by enlargement of intrathoracic lymphatic nodes in 14.3% and 53.0% cases, respectively. The data obtained with Diaskin probe were confirmed by a reference QuantiFERON testing in 95% cases. Parameters of diagnostic value for Diaskin test are two-fold higher than for Mantoux test with 2 TE. Positivity for Diaskin test reflects activity of tuberculosis infection which is accompanied by clear clinical signs in 67.3% cases, and, in 80% cases, it ischaracterized by enlargement of intrathoracic lymphatic nodes as based on radiologic data, thus arranging a risk group for tuberculosis morbidity in children. Appropriate recommendations for these patients include a fullscale phthisiatric assessment and administration of well justified and adequate therapy.P. K. IablonskiyI. F. DovgaljukA. A. StarshinovaO. A. IakunovaSPb RAACIarticletuberculosischildrendiaskin testcomputer tomographydiagnosticsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 1, Pp 37-44 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	tuberculosis children diaskin test computer tomography diagnostics Immunologic diseases. Allergy RC581-607
spellingShingle	tuberculosis children diaskin test computer tomography diagnostics Immunologic diseases. Allergy RC581-607 P. K. Iablonskiy I. F. Dovgaljuk A. A. Starshinova O. A. Iakunova ROLE OF MODERN IMMUNOLOGIC TESTS IN DIAGNOSTICS OF TUBERCULOSIS IN CHILDREN
description	Present study has revealed low diagnostic value of Mantoux test with 2 TE in detection of tuberculosis in MBT-infected children, thus requiring implementation of novel methods. Detectable activity of tuberculosis infection among observed children with low tuberculin sensitivity was found in 23.8% of cases, as revealed by Diaskin test, as compared to 42.7% cases in a group with moderate sensitivity to tuberculin. As shown by radiological data it was accompanied by enlargement of intrathoracic lymphatic nodes in 14.3% and 53.0% cases, respectively. The data obtained with Diaskin probe were confirmed by a reference QuantiFERON testing in 95% cases. Parameters of diagnostic value for Diaskin test are two-fold higher than for Mantoux test with 2 TE. Positivity for Diaskin test reflects activity of tuberculosis infection which is accompanied by clear clinical signs in 67.3% cases, and, in 80% cases, it ischaracterized by enlargement of intrathoracic lymphatic nodes as based on radiologic data, thus arranging a risk group for tuberculosis morbidity in children. Appropriate recommendations for these patients include a fullscale phthisiatric assessment and administration of well justified and adequate therapy.
format	article
author	P. K. Iablonskiy I. F. Dovgaljuk A. A. Starshinova O. A. Iakunova
author_facet	P. K. Iablonskiy I. F. Dovgaljuk A. A. Starshinova O. A. Iakunova
author_sort	P. K. Iablonskiy
title	ROLE OF MODERN IMMUNOLOGIC TESTS IN DIAGNOSTICS OF TUBERCULOSIS IN CHILDREN
title_short	ROLE OF MODERN IMMUNOLOGIC TESTS IN DIAGNOSTICS OF TUBERCULOSIS IN CHILDREN
title_full	ROLE OF MODERN IMMUNOLOGIC TESTS IN DIAGNOSTICS OF TUBERCULOSIS IN CHILDREN
title_fullStr	ROLE OF MODERN IMMUNOLOGIC TESTS IN DIAGNOSTICS OF TUBERCULOSIS IN CHILDREN
title_full_unstemmed	ROLE OF MODERN IMMUNOLOGIC TESTS IN DIAGNOSTICS OF TUBERCULOSIS IN CHILDREN
title_sort	role of modern immunologic tests in diagnostics of tuberculosis in children
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/2ef57e2e64044786ba85ee148241c8d8
work_keys_str_mv	AT pkiablonskiy roleofmodernimmunologictestsindiagnosticsoftuberculosisinchildren AT ifdovgaljuk roleofmodernimmunologictestsindiagnosticsoftuberculosisinchildren AT aastarshinova roleofmodernimmunologictestsindiagnosticsoftuberculosisinchildren AT oaiakunova roleofmodernimmunologictestsindiagnosticsoftuberculosisinchildren
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ROLE OF MODERN IMMUNOLOGIC TESTS IN DIAGNOSTICS OF TUBERCULOSIS IN CHILDREN

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