A coordinated progression of progenitor cell states initiates urinary tract development

Nephric duct (ND)-derived ureteric buds (UB) form the kidney collecting duct system, while ureteric tips promote nephron formation. Here the authors use single-cell RNA-seq and introduce Cluster RNA-seq to identify four progenitor populations in developing ND/UB regulated by the transcription factor...

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Autores principales: Oraly Sanchez-Ferras, Alain Pacis, Maria Sotiropoulou, Yuhong Zhang, Yu Chang Wang, Mathieu Bourgey, Guillaume Bourque, Jiannis Ragoussis, Maxime Bouchard
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2ef679d5c21a4d05af1a81f482877344
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Sumario:Nephric duct (ND)-derived ureteric buds (UB) form the kidney collecting duct system, while ureteric tips promote nephron formation. Here the authors use single-cell RNA-seq and introduce Cluster RNA-seq to identify four progenitor populations in developing ND/UB regulated by the transcription factors Tfap2a/b and Gata3.