Prdm6 is essential for cardiovascular development in vivo.
Members of the PRDM protein family have been shown to play important roles during embryonic development. Previous in vitro and in situ analyses indicated a function of Prdm6 in cells of the vascular system. To reveal physiological functions of Prdm6, we generated conditional Prdm6-deficient mice. Co...
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2013
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oai:doaj.org-article:2ef6f78b77f04d17b6424b9237d110972021-11-18T08:45:07ZPrdm6 is essential for cardiovascular development in vivo.1932-620310.1371/journal.pone.0081833https://doaj.org/article/2ef6f78b77f04d17b6424b9237d110972013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24278461/?tool=EBIhttps://doaj.org/toc/1932-6203Members of the PRDM protein family have been shown to play important roles during embryonic development. Previous in vitro and in situ analyses indicated a function of Prdm6 in cells of the vascular system. To reveal physiological functions of Prdm6, we generated conditional Prdm6-deficient mice. Complete deletion of Prdm6 results in embryonic lethality due to cardiovascular defects associated with aberrations in vascular patterning. However, smooth muscle cells could be regularly differentiated from Prdm6-deficient embryonic stem cells and vascular smooth muscle cells were present and proliferated normally in Prdm6-deficient embryos. Conditional deletion of Prdm6 in the smooth muscle cell lineage using a SM22-Cre driver line resulted in perinatal lethality due to hemorrhage in the lungs. We thus identified Prdm6 as a factor that is essential for the physiological control of cardiovascular development.Andreas GewiesMercedes Castineiras-VilarinoUta FerchNina JährlingKatja HeinrichUlrike HoeckendorfGerhard K H PrzemeckMatthias MundingOlaf GroßTimm SchroederMarion HorschE Loraine KarranAneela MajidStefan AntonowiczJohannes BeckersMartin Hrabé de AngelisHans-Ulrich DodtChristian PeschelIrmgard FörsterMartin J S DyerJürgen RulandPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e81833 (2013) |
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Medicine R Science Q Andreas Gewies Mercedes Castineiras-Vilarino Uta Ferch Nina Jährling Katja Heinrich Ulrike Hoeckendorf Gerhard K H Przemeck Matthias Munding Olaf Groß Timm Schroeder Marion Horsch E Loraine Karran Aneela Majid Stefan Antonowicz Johannes Beckers Martin Hrabé de Angelis Hans-Ulrich Dodt Christian Peschel Irmgard Förster Martin J S Dyer Jürgen Ruland Prdm6 is essential for cardiovascular development in vivo. |
| description |
Members of the PRDM protein family have been shown to play important roles during embryonic development. Previous in vitro and in situ analyses indicated a function of Prdm6 in cells of the vascular system. To reveal physiological functions of Prdm6, we generated conditional Prdm6-deficient mice. Complete deletion of Prdm6 results in embryonic lethality due to cardiovascular defects associated with aberrations in vascular patterning. However, smooth muscle cells could be regularly differentiated from Prdm6-deficient embryonic stem cells and vascular smooth muscle cells were present and proliferated normally in Prdm6-deficient embryos. Conditional deletion of Prdm6 in the smooth muscle cell lineage using a SM22-Cre driver line resulted in perinatal lethality due to hemorrhage in the lungs. We thus identified Prdm6 as a factor that is essential for the physiological control of cardiovascular development. |
| format |
article |
| author |
Andreas Gewies Mercedes Castineiras-Vilarino Uta Ferch Nina Jährling Katja Heinrich Ulrike Hoeckendorf Gerhard K H Przemeck Matthias Munding Olaf Groß Timm Schroeder Marion Horsch E Loraine Karran Aneela Majid Stefan Antonowicz Johannes Beckers Martin Hrabé de Angelis Hans-Ulrich Dodt Christian Peschel Irmgard Förster Martin J S Dyer Jürgen Ruland |
| author_facet |
Andreas Gewies Mercedes Castineiras-Vilarino Uta Ferch Nina Jährling Katja Heinrich Ulrike Hoeckendorf Gerhard K H Przemeck Matthias Munding Olaf Groß Timm Schroeder Marion Horsch E Loraine Karran Aneela Majid Stefan Antonowicz Johannes Beckers Martin Hrabé de Angelis Hans-Ulrich Dodt Christian Peschel Irmgard Förster Martin J S Dyer Jürgen Ruland |
| author_sort |
Andreas Gewies |
| title |
Prdm6 is essential for cardiovascular development in vivo. |
| title_short |
Prdm6 is essential for cardiovascular development in vivo. |
| title_full |
Prdm6 is essential for cardiovascular development in vivo. |
| title_fullStr |
Prdm6 is essential for cardiovascular development in vivo. |
| title_full_unstemmed |
Prdm6 is essential for cardiovascular development in vivo. |
| title_sort |
prdm6 is essential for cardiovascular development in vivo. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/2ef6f78b77f04d17b6424b9237d11097 |
| work_keys_str_mv |
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