Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway

Mutations in PHF8 gene are genetically associated with X-linked mental retardation. Here, Chen et al. show that Phf8 KO mouse have cognitive and synaptic plasticity impairment, and pharmacological inhibition of mTOR signaling can partially alleviate such defects.

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Autores principales:	Xuemei Chen, Shuai Wang, Ying Zhou, Yanfei Han, Shengtian Li, Qing Xu, Longyong Xu, Ziqi Zhu, Youming Deng, Lu Yu, Lulu Song, Adele Pin Chen, Juan Song, Eiki Takahashi, Guang He, Lin He, Weidong Li, Charlie Degui Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2ef75b4f01b048c09a3f547f5a48ff9a
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spelling	oai:doaj.org-article:2ef75b4f01b048c09a3f547f5a48ff9a2021-12-02T15:34:15ZPhf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway10.1038/s41467-017-02531-y2041-1723https://doaj.org/article/2ef75b4f01b048c09a3f547f5a48ff9a2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02531-yhttps://doaj.org/toc/2041-1723Mutations in PHF8 gene are genetically associated with X-linked mental retardation. Here, Chen et al. show that Phf8 KO mouse have cognitive and synaptic plasticity impairment, and pharmacological inhibition of mTOR signaling can partially alleviate such defects.Xuemei ChenShuai WangYing ZhouYanfei HanShengtian LiQing XuLongyong XuZiqi ZhuYouming DengLu YuLulu SongAdele Pin ChenJuan SongEiki TakahashiGuang HeLin HeWeidong LiCharlie Degui ChenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xuemei Chen Shuai Wang Ying Zhou Yanfei Han Shengtian Li Qing Xu Longyong Xu Ziqi Zhu Youming Deng Lu Yu Lulu Song Adele Pin Chen Juan Song Eiki Takahashi Guang He Lin He Weidong Li Charlie Degui Chen Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway
description	Mutations in PHF8 gene are genetically associated with X-linked mental retardation. Here, Chen et al. show that Phf8 KO mouse have cognitive and synaptic plasticity impairment, and pharmacological inhibition of mTOR signaling can partially alleviate such defects.
format	article
author	Xuemei Chen Shuai Wang Ying Zhou Yanfei Han Shengtian Li Qing Xu Longyong Xu Ziqi Zhu Youming Deng Lu Yu Lulu Song Adele Pin Chen Juan Song Eiki Takahashi Guang He Lin He Weidong Li Charlie Degui Chen
author_facet	Xuemei Chen Shuai Wang Ying Zhou Yanfei Han Shengtian Li Qing Xu Longyong Xu Ziqi Zhu Youming Deng Lu Yu Lulu Song Adele Pin Chen Juan Song Eiki Takahashi Guang He Lin He Weidong Li Charlie Degui Chen
author_sort	Xuemei Chen
title	Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway
title_short	Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway
title_full	Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway
title_fullStr	Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway
title_full_unstemmed	Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway
title_sort	phf8 histone demethylase deficiency causes cognitive impairments through the mtor pathway
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2ef75b4f01b048c09a3f547f5a48ff9a
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Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway

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