Characteristics of contrast‐enhanced ultrasound for diagnosis of solid clear cell renal cell carcinomas ≤4 cm: A meta‐analysis

Abstract Now solid renal tumors ≤4 cm is the most common, especially the subtype of clear cell renal cell carcinoma (ccRCC) of malignant kidney tumors in clinical. However, there is not specific characteristics of contrast‐enhanced ultrasound (CEUS) be recommended by the EFSUMB Guidelines in disting...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yang Liu, Yanmin Kan, Jincun Zhang, Ning Li, Yihua Wang
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	clear cell renal cell carcinoma contrast‐enhanced ultrasound meta‐analysis solid tumor tumor characteristics Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/2ef7f129e6914fd2af06dcf9d35ee35b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2ef7f129e6914fd2af06dcf9d35ee35b
record_format	dspace
spelling	oai:doaj.org-article:2ef7f129e6914fd2af06dcf9d35ee35b2021-12-01T04:49:14ZCharacteristics of contrast‐enhanced ultrasound for diagnosis of solid clear cell renal cell carcinomas ≤4 cm: A meta‐analysis2045-763410.1002/cam4.4365https://doaj.org/article/2ef7f129e6914fd2af06dcf9d35ee35b2021-12-01T00:00:00Zhttps://doi.org/10.1002/cam4.4365https://doaj.org/toc/2045-7634Abstract Now solid renal tumors ≤4 cm is the most common, especially the subtype of clear cell renal cell carcinoma (ccRCC) of malignant kidney tumors in clinical. However, there is not specific characteristics of contrast‐enhanced ultrasound (CEUS) be recommended by the EFSUMB Guidelines in distinguish the essence of the kidney tumor with different sizes. Therefore, this meta‐analysis aimed to assess the ability of CEUS to diagnose solid ccRCC (sccRCC) ≤4 cm. We comprehensively searched the Cochrane Library, Embase, PubMed, and Web of Science databases from their inception to 28 July 2020, for studies reporting the CEUS features of sccRCC lesions ≤4 cm. Additional articles were identified through the Chinese National Knowledge Infrastructure database. Studies were selected independently by two investigators and the relevant data were extracted. Discrepancies were resolved via discussion with the senior author. Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies‐2 tool, and the sensitivity and specificity of each study were determined and plotted as a receiver operating characteristic curve. Ten studies were included in this meta‐analysis. Hyperenhancement showed medium sensitivity (67%–89%) and specificity (42%–75%) for diagnosing sccRCC ≤4 cm, fast‐in contrast agent and heterogeneous enhancement showed high diagnostic abilities (area under curve (AUC) 0.74–0.84), but the presence of a pseudocapsule and fast‐out contrast agent had poor diagnostic ability (AUC <0.70). The combination of hyperenhancement and iso‐enhancement showed high sensitivity (98%) for diagnosing sccRCC ≤4 cm. Hyperenhancement, fast‐in contrast agent, and heterogeneous enhancement may be specific features that could help to identify sccRCC ≤4 cm, while the presence of a pseudocapsule and fast‐out of contrast agent may have low diagnostic values. The combination of multiple indexes may improve the diagnostic value of CEUS for sccRCC ≤4 cm.Yang LiuYanmin KanJincun ZhangNing LiYihua WangWileyarticleclear cell renal cell carcinomacontrast‐enhanced ultrasoundmeta‐analysissolid tumortumor characteristicsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Medicine, Vol 10, Iss 23, Pp 8288-8299 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	clear cell renal cell carcinoma contrast‐enhanced ultrasound meta‐analysis solid tumor tumor characteristics Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	clear cell renal cell carcinoma contrast‐enhanced ultrasound meta‐analysis solid tumor tumor characteristics Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yang Liu Yanmin Kan Jincun Zhang Ning Li Yihua Wang Characteristics of contrast‐enhanced ultrasound for diagnosis of solid clear cell renal cell carcinomas ≤4 cm: A meta‐analysis
description	Abstract Now solid renal tumors ≤4 cm is the most common, especially the subtype of clear cell renal cell carcinoma (ccRCC) of malignant kidney tumors in clinical. However, there is not specific characteristics of contrast‐enhanced ultrasound (CEUS) be recommended by the EFSUMB Guidelines in distinguish the essence of the kidney tumor with different sizes. Therefore, this meta‐analysis aimed to assess the ability of CEUS to diagnose solid ccRCC (sccRCC) ≤4 cm. We comprehensively searched the Cochrane Library, Embase, PubMed, and Web of Science databases from their inception to 28 July 2020, for studies reporting the CEUS features of sccRCC lesions ≤4 cm. Additional articles were identified through the Chinese National Knowledge Infrastructure database. Studies were selected independently by two investigators and the relevant data were extracted. Discrepancies were resolved via discussion with the senior author. Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies‐2 tool, and the sensitivity and specificity of each study were determined and plotted as a receiver operating characteristic curve. Ten studies were included in this meta‐analysis. Hyperenhancement showed medium sensitivity (67%–89%) and specificity (42%–75%) for diagnosing sccRCC ≤4 cm, fast‐in contrast agent and heterogeneous enhancement showed high diagnostic abilities (area under curve (AUC) 0.74–0.84), but the presence of a pseudocapsule and fast‐out contrast agent had poor diagnostic ability (AUC <0.70). The combination of hyperenhancement and iso‐enhancement showed high sensitivity (98%) for diagnosing sccRCC ≤4 cm. Hyperenhancement, fast‐in contrast agent, and heterogeneous enhancement may be specific features that could help to identify sccRCC ≤4 cm, while the presence of a pseudocapsule and fast‐out of contrast agent may have low diagnostic values. The combination of multiple indexes may improve the diagnostic value of CEUS for sccRCC ≤4 cm.
format	article
author	Yang Liu Yanmin Kan Jincun Zhang Ning Li Yihua Wang
author_facet	Yang Liu Yanmin Kan Jincun Zhang Ning Li Yihua Wang
author_sort	Yang Liu
title	Characteristics of contrast‐enhanced ultrasound for diagnosis of solid clear cell renal cell carcinomas ≤4 cm: A meta‐analysis
title_short	Characteristics of contrast‐enhanced ultrasound for diagnosis of solid clear cell renal cell carcinomas ≤4 cm: A meta‐analysis
title_full	Characteristics of contrast‐enhanced ultrasound for diagnosis of solid clear cell renal cell carcinomas ≤4 cm: A meta‐analysis
title_fullStr	Characteristics of contrast‐enhanced ultrasound for diagnosis of solid clear cell renal cell carcinomas ≤4 cm: A meta‐analysis
title_full_unstemmed	Characteristics of contrast‐enhanced ultrasound for diagnosis of solid clear cell renal cell carcinomas ≤4 cm: A meta‐analysis
title_sort	characteristics of contrast‐enhanced ultrasound for diagnosis of solid clear cell renal cell carcinomas ≤4 cm: a meta‐analysis
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/2ef7f129e6914fd2af06dcf9d35ee35b
work_keys_str_mv	AT yangliu characteristicsofcontrastenhancedultrasoundfordiagnosisofsolidclearcellrenalcellcarcinomas4cmametaanalysis AT yanminkan characteristicsofcontrastenhancedultrasoundfordiagnosisofsolidclearcellrenalcellcarcinomas4cmametaanalysis AT jincunzhang characteristicsofcontrastenhancedultrasoundfordiagnosisofsolidclearcellrenalcellcarcinomas4cmametaanalysis AT ningli characteristicsofcontrastenhancedultrasoundfordiagnosisofsolidclearcellrenalcellcarcinomas4cmametaanalysis AT yihuawang characteristicsofcontrastenhancedultrasoundfordiagnosisofsolidclearcellrenalcellcarcinomas4cmametaanalysis
_version_	1718405717488041984

Characteristics of contrast‐enhanced ultrasound for diagnosis of solid clear cell renal cell carcinomas ≤4 cm: A meta‐analysis

Ejemplares similares